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公开(公告)号：US5856326A
公开(公告)日：1999-01-05
申请号：US600728
申请日：1996-03-01
申请人： Neville J. Anthony , Terrence M. Ciccarone , Christopher J. Dinsmore , Robert P. Gomez , Theresa M. Williams , George D. Hartman
发明人： Neville J. Anthony , Terrence M. Ciccarone , Christopher J. Dinsmore , Robert P. Gomez , Theresa M. Williams , George D. Hartman
IPC分类号： C07D233/54 , C07D241/08 , C07D295/192 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , A61K31/495 , C07D241/04
CPC分类号： C07D233/64 , C07D241/08 , C07D295/192 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12
摘要： The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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公开(公告)号：US5736539A
公开(公告)日：1998-04-07
申请号：US549829
申请日：1995-11-16
IPC分类号： C12N9/99 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/505 , A61P35/00 , A61P43/00 , C07D213/74 , C07D215/48 , C07D215/50 , C07D217/26 , C07D241/04 , C07D295/13 , C07D295/18 , C07D295/192 , C07D307/79 , C07D333/24 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/06 , A61K31/55 , C07D243/08 , C07D401/00
CPC分类号： C07D295/192 , C07D215/48 , C07D241/04 , C07D295/13 , C07D307/79 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/06 , C07D409/06
摘要： The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras. The compounds of formula A are representative of the compounds of the present invention: ##STR1##
摘要翻译： PCT No.PCT / US94 / 05634 Sec。 371日期：1995年11月16日 102（e）1995年11月16日PCT PCT 1994年5月19日PCT公布。 公开号WO95 / 日期1995年1月5日本发明涉及抑制法呢基蛋白转移酶（FTase）和致癌基因蛋白Ras的法呢基化的化合物。 本发明进一步涉及含有本发明化合物的化疗组合物和抑制法呢基蛋白转移酶的方法和癌基因蛋白Ras的法呢基化。 式A的化合物是本发明化合物的代表：
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公开(公告)号：US20130210804A1
公开(公告)日：2013-08-15
申请号：US13880171
申请日：2011-10-20
申请人： Neville J. Anthony , Robert P. Gomez , Jing Li , Swati P. Mercer , Anthony J. Roecker , Craig A. Stump , Theresa M. Williams
发明人： Neville J. Anthony , Robert P. Gomez , Jing Li , Swati P. Mercer , Anthony J. Roecker , Craig A. Stump , Theresa M. Williams
IPC分类号： C07D513/04 , C07D498/04 , C07D471/14 , C07D471/04
CPC分类号： C07D513/04 , C07D471/04 , C07D471/14 , C07D498/04
摘要： The present invention is directed to tricyclic compounds which are positive allosteric modulators of metabotropic glutamate receptors, particularly the mGluR5 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
摘要翻译： 本发明涉及三环化合物，其是代谢型谷氨酸受体，特别是mGluR5受体的正性变构调节剂，其可用于治疗或预防与谷氨酸功能障碍相关的神经和精神病症以及涉及代谢型谷氨酸受体的疾病 。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及代谢型谷氨酸受体的疾病中的用途。
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公开(公告)号：US07491713B2
公开(公告)日：2009-02-17
申请号：US10587121
申请日：2005-01-25
申请人： Christopher S. Burgey , Daniel V. Paone , Anthony W Shaw , Craig A. Stump , Theresa M. Williams
发明人： Christopher S. Burgey , Daniel V. Paone , Anthony W Shaw , Craig A. Stump , Theresa M. Williams
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , A61K31/4178 , A61K31/4439 , A61K31/551 , A61K31/553 , A61K31/554 , A61P25/06
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14
摘要： Compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, D, G, J, Q, T, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, pharmaceutical compositions comprising these compounds, use of these compounds and compositions to prevent or treat diseases involving CGRP.
摘要翻译： 式I：和式II化合物（其中变量R1，R2，R3，R4，A，B，D，G，J，Q，T，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂 并且可用于治疗或预防涉及CGRP的疾病，包含这些化合物的药物组合物，这些化合物和组合物的用途，以预防或治疗涉及CGRP的疾病。
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公开(公告)号：US20080113966A1
公开(公告)日：2008-05-15
申请号：US11665523
申请日：2005-10-12
申请人： Christopher S. Burgey , Daniel V. Paone , Anthony W. Shaw , Diem N. Nguyen , Zhengwu J. Deng , Theresa M. Williams , Joseph P. Vacca , Craig M. Potteiger , Harold G. Selnick
发明人： Christopher S. Burgey , Daniel V. Paone , Anthony W. Shaw , Diem N. Nguyen , Zhengwu J. Deng , Theresa M. Williams , Joseph P. Vacca , Craig M. Potteiger , Harold G. Selnick
IPC分类号： A61K31/553 , A61K31/551 , A61K31/55 , C07D498/04 , C07D487/04
CPC分类号： C07D487/04
摘要： Compounds of Formula (I): and Formula (II): (where variables R2, R4, A, B, D, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 式（I）：和式（II）的化合物：（其中变量R 2，R 4，A，B，D，W，X，Y和Z分别为 如本文所定义）可用作CGRP受体的拮抗剂并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US06953790B2
公开(公告)日：2005-10-11
申请号：US10838835
申请日：2004-05-04
申请人： Christopher S. Burgey , Zhengwu J. Deng , Diem N. Nguyen , Daniel V. Paone , Anthony W. Shaw , Theresa M. Williams
发明人： Christopher S. Burgey , Zhengwu J. Deng , Diem N. Nguyen , Daniel V. Paone , Anthony W. Shaw , Theresa M. Williams
IPC分类号： A61K31/4188 , A61K31/55 , A61K31/553 , A61K31/554 , A61P25/06 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/00 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention is directed to compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物和式II化合物：其中R 1，R 2，R 3，R 3， A，B，G，J，Q，T，U，V，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防 CGRP涉及，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US06534506B2
公开(公告)日：2003-03-18
申请号：US09828259
申请日：2001-04-06
IPC分类号： C07D49822
CPC分类号： C07D498/22 , C07D513/22
摘要： The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
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公开(公告)号：US5972942A
公开(公告)日：1999-10-26
申请号：US827485
申请日：1997-03-27
申请人： Dong D. Wei , Theresa M. Williams
发明人： Dong D. Wei , Theresa M. Williams
IPC分类号： C07D401/04 , C07D401/06 , C07D403/06 , C07D403/00 , A61K31/495
CPC分类号： C07D401/04 , C07D401/06 , C07D403/06
摘要： The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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公开(公告)号：US5965578A
公开(公告)日：1999-10-12
申请号：US823934
申请日：1997-03-25
IPC分类号： C07D401/06 , A61K31/445
CPC分类号： C07D401/06
摘要： The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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公开(公告)号：US5919785A
公开(公告)日：1999-07-06
申请号：US823921
申请日：1997-03-25
IPC分类号： C07D233/54 , C07D401/06 , C07D403/06 , A61K31/415 , A61K31/495 , C07D241/08
CPC分类号： C07D401/06 , C07D403/06
摘要： The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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