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公开(公告)号：US08933228B2
公开(公告)日：2015-01-13
申请号：US13805471
申请日：2011-06-17
IPC分类号： A61K31/50 , C07D515/02 , C07D471/00 , C07D471/04 , A61K31/437 , A61K31/4985 , C07D487/04 , C07D473/30 , C07D475/02 , A61K9/00
CPC分类号： C07D471/04 , A61K9/0075 , A61K31/437 , A61K31/4985 , C07D473/30 , C07D475/02 , C07D487/04 , Y10T428/2982
摘要： The present invention relates to respiratory formulations comprising a compound of formula (I): and use of said compounds and compositions in treatment, for example in the treatment of an inflammatory disease or a respiratory disorder, in particular an inflammatory mediated and/or virally mediated respiratory disorder such as asthma and COPD or the treatment or prevention of viral infection, for example infection by influenza virus, rhinovirus or RSV. The invention also extends to certain novel compounds of formula (I).
摘要翻译： 本发明涉及包含式（I）化合物的呼吸制剂：以及所述化合物和组合物在治疗中的用途，例如治疗炎性疾病或呼吸障碍，特别是炎性介导和/或病毒介导的 呼吸障碍如哮喘和COPD或治疗或预防病毒感染，例如流感病毒，鼻病毒或RSV感染。 本发明还延伸到某些新的式（I）化合物。
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公开(公告)号：US08741909B2
公开(公告)日：2014-06-03
申请号：US13502465
申请日：2010-10-19
申请人： John King-Underwood , Kazuhiro Ito , Peter John Murray , George Hardy , Frederick Arthur Brookfield , Christopher John Brown
发明人： John King-Underwood , Kazuhiro Ito , Peter John Murray , George Hardy , Frederick Arthur Brookfield , Christopher John Brown
IPC分类号： A61K31/4985 , C07D471/04
CPC分类号： C07D487/04 , A61K31/4965
摘要： The present invention relates to compounds of formula (I) and to compositions comprising the same and to the use of the compounds and their compositions in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making the compounds.
摘要翻译： 本发明涉及式（I）化合物和包含其的组合物，以及该化合物及其组合物在治疗中的用途，例如用于治疗炎性疾病，特别是呼吸道炎性疾病。 本发明还涉及制备化合物的方法。
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公开(公告)号：US20120208799A1
公开(公告)日：2012-08-16
申请号：US13502465
申请日：2010-10-19
申请人： John King-Underwood , Kazuhlro Ito , Peter John Murray , George Hardy , Frederick Arthur Brookfield , Christopher John Brown
发明人： John King-Underwood , Kazuhlro Ito , Peter John Murray , George Hardy , Frederick Arthur Brookfield , Christopher John Brown
IPC分类号： A61K31/519 , A61K31/5377 , A61K31/551 , A61P35/00 , A61P19/02 , A61P29/00 , A61P11/02 , A61P17/00 , A61P17/06 , A61P1/00 , C07D487/04 , A61P11/00
CPC分类号： C07D487/04 , A61K31/4965
摘要： The present invention relates to compounds of formula (I) and to compositions comprising the same and to the use of the compounds and their compositions in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making said compounds.
摘要翻译： 本发明涉及式（I）化合物和包含其的组合物，以及该化合物及其组合物在治疗中的用途，例如用于治疗炎性疾病，特别是呼吸道炎性疾病。 本发明还涉及制备所述化合物的方法。
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24.发明授权Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase 有权糖基磷酸化酶的吡咯并吡啶-2-羧酸酰胺抑制剂公开(公告)号：US08158622B2
公开(公告)日：2012-04-17
申请号：US12217157
申请日：2008-07-02
申请人： Stuart Edward Bradley , Thomas Martin Krulle , Peter John Murray , Martin James Procter , Robert John Rowley , Colin Peter Sambrook Smith , Gerard Hugh Thomas , Karen Lesley Schofield
发明人： Stuart Edward Bradley , Thomas Martin Krulle , Peter John Murray , Martin James Procter , Robert John Rowley , Colin Peter Sambrook Smith , Gerard Hugh Thomas , Karen Lesley Schofield
IPC分类号： C07D471/02 , A61K31/44
CPC分类号： C07D471/04
摘要： Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.
摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐是糖原磷酸化酶的抑制剂，可用于预防或治疗糖尿病，高血糖症，高胆固醇血症，高胰岛素血症，高脂血症，高血压，动脉粥样硬化或组织缺血。 心肌缺血，以及心脏保护剂。
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公开(公告)号：US20090221824A1
公开(公告)日：2009-09-03
申请号：US11573471
申请日：2005-08-12
申请人： Paul Howard Briner , Matthew Colin Thor Fyfe , John Paul Madeley , Peter John Murray , Martin James Procter , Felix Spindler
发明人： Paul Howard Briner , Matthew Colin Thor Fyfe , John Paul Madeley , Peter John Murray , Martin James Procter , Felix Spindler
IPC分类号： C07D405/12 , C07D315/00 , C07D417/12
CPC分类号： C07D405/12 , C07D309/04 , C07D417/12
摘要： A process for the production of compounds comprising the enantioselective hydrogenation of 2-substituted acrylic acid derivatives.
摘要翻译： 一种制备包含2-取代的丙烯酸衍生物的对映选择性氢化的化合物的方法。
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26.发明申请Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase 有权糖基磷酸化酶的吡咯并吡啶-2-羧酸酰胺抑制剂公开(公告)号：US20090023703A1
公开(公告)日：2009-01-22
申请号：US12217157
申请日：2008-07-02
申请人： Stuart Edward Bradley , Thomas Martin Krulle , Peter John Murray , Martin James Procter , Robert John Rowley , Colin Peter Sambrook Smith , Gerard Hugh Thomas
发明人： Stuart Edward Bradley , Thomas Martin Krulle , Peter John Murray , Martin James Procter , Robert John Rowley , Colin Peter Sambrook Smith , Gerard Hugh Thomas
IPC分类号： A61K31/437 , C07D471/04 , A61K31/5377 , C07D263/04 , A61P3/10
CPC分类号： C07D471/04
摘要： Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.
摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐是糖原磷酸化酶的抑制剂，可用于预防或治疗糖尿病，高血糖症，高胆固醇血症，高胰岛素血症，高脂血症，高血压，动脉粥样硬化或组织缺血。 心肌缺血，以及心脏保护剂。
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27.发明授权Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase 有权糖基磷酸化酶的吡咯并吡啶-2-羧酸酰胺抑制剂公开(公告)号：US07405210B2
公开(公告)日：2008-07-29
申请号：US10851902
申请日：2004-05-20
申请人： Stuart Edward Bradley , Thomas Martin Krulle , Peter John Murray , Martin James Procter , Robert John Rowley , Colin Peter Sambrook Smith , Gerard Hugh Thomas
发明人： Stuart Edward Bradley , Thomas Martin Krulle , Peter John Murray , Martin James Procter , Robert John Rowley , Colin Peter Sambrook Smith , Gerard Hugh Thomas
IPC分类号： C07D471/02 , A61K31/44
CPC分类号： C07D471/04
摘要： Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.
摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐是糖原磷酸化酶的抑制剂，可用于预防或治疗糖尿病，高血糖症，高胆固醇血症，高胰岛素血症，高脂血症，高血压，动脉粥样硬化或组织缺血。 心肌缺血，以及心脏保护剂。
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