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21.发明授权4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds 失效4-（取代的环烷基甲基）咪唑-2-硫酮，4-（取代的环烯基甲基）咪唑-2-硫酮，4-（取代的环烷基甲基）咪唑-2-酮和4-（取代的环烯基甲基）咪唑-2-酮和相关化合物公开(公告)号：US07323485B2
公开(公告)日：2008-01-29
申请号：US11555831
申请日：2006-11-02
IPC分类号： A61K31/4164 , C07D233/54
CPC分类号： C07D233/84 , C07D233/70 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D409/08
摘要： Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors, and as such have no or only minimal cardivascular and/or sedatory activity. These compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2B adrenergic receptors. Compounds of Formula 1 where X is O also have the advantageous property that they have no or only minimal cardivascular and/or sedatory activity and are useful for treating pain and other conditions with no or only minimal cardivascular and/or sedatory activity.
摘要翻译： 式1的化合物，其中X为S且变量具有本说明书中定义的含义，优先选择于α2B2和/或α2C2肾上腺素能受体 2A肾上腺素能受体，因此没有或仅有最小的血管内和/或镇静作用。 式1的这些化合物可用作哺乳动物（包括人）中的药物，用于治疗疾病和/或缓解对α2B2肾上腺素能受体的激动剂治疗有反应的病症。 其中X是O的式1化合物也具有它们没有或只有最小的血管内和/或镇静作用的有利性质，并且可用于治疗没有或仅有最小血管和/或镇静作用的疼痛和其它病症。
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22.发明授权公开(公告)号：US06313172B1
公开(公告)日：2001-11-06
申请号：US09548410
申请日：2000-04-13
申请人： Ken Chow , Daniel W. Gil , Wenkui Ken Fang , Michael E. Garst , Larry A. Wheeler
发明人： Ken Chow , Daniel W. Gil , Wenkui Ken Fang , Michael E. Garst , Larry A. Wheeler
IPC分类号： A61K3117
CPC分类号： A61K31/17 , C07C335/12
摘要： Methods and compositions for the treatment of pain using this area derivatives. Particularly disclosed are new compositions for the treatment of chronic pain, and methods for their use.
摘要翻译： 使用该区域衍生物治疗疼痛的方法和组合物。 特别公开了用于治疗慢性疼痛的新组合物及其使用方法。
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公开(公告)号：US07960423B2
公开(公告)日：2011-06-14
申请号：US11873537
申请日：2007-10-17
IPC分类号： A61K31/4164 , C07D233/30
CPC分类号： C07D233/84 , C07D233/70 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D409/08
摘要： Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors, and as such have no or only minimal cardivascular and/or sedatory activity. These compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2B adrenergic receptors. Compounds of Formula 1 where X is O also have the advantageous property that they have no or only minimal cardivascular and/or sedatory activity and are useful for treating pain and other conditions with no or only minimal cardivascular and/or sedatory activity.
摘要翻译： 式1的化合物，其中X为S且变量具有本说明书中定义的含义，优先于α2B肾上腺素能受体，对α2B和/或α2C肾上腺素能受体是特异性或选择性的，因此没有或仅有最小的血管内和/或镇静 活动。 式1的这些化合物可用作哺乳动物（包括人）中用于治疗疾病的药物和/或缓解对α2B肾上腺素能受体的激动剂治疗有反应的病症。 其中X是O的式1化合物也具有它们没有或只有最小的血管内和/或镇静作用的有利性质，并且可用于治疗没有或仅有最小血管和/或镇静作用的疼痛和其它病症。
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24.发明授权公开(公告)号：US07754768B2
公开(公告)日：2010-07-13
申请号：US12024609
申请日：2008-02-01
申请人： Ken Chow , Daniel W. Gil , Wenkui Ken Fang , Michael E. Garst , Larry A. Wheeler
发明人： Ken Chow , Daniel W. Gil , Wenkui Ken Fang , Michael E. Garst , Larry A. Wheeler
IPC分类号： A61K31/17
CPC分类号： A61K31/17 , Y10S514/913
摘要： Methods and compositions for the treatment of pain and intraocular pressure. Particularly disclosed are new compositions for the treatment of chronic pain, glaucoma and methods for their use.
摘要翻译： 用于治疗疼痛和眼内压的方法和组合物。 特别公开了用于治疗慢性疼痛，青光眼的新组合物及其使用方法。
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25.发明授权公开(公告)号：US07335803B2
公开(公告)日：2008-02-26
申请号：US10039827
申请日：2001-10-19
申请人： Ken Chow , Daniel W. Gil , Wenkui Ken Fang , Michael E. Garst , Larry A. Wheeler
发明人： Ken Chow , Daniel W. Gil , Wenkui Ken Fang , Michael E. Garst , Larry A. Wheeler
CPC分类号： A61K31/17 , Y10S514/913
摘要： Methods and compositions for the treatment of pain and intraocular pressure. Particularly disclosed are new compositions for the treatment of chronic pain, glaucoma and methods for their use.
摘要翻译： 用于治疗疼痛和眼内压的方法和组合物。 特别公开了用于治疗慢性疼痛，青光眼的新组合物及其使用方法。
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26.发明申请4-(HETEROARYL-METHYL AND SUBSTITUTED HETEROARYL-METHYL)-IMIDAZOLE-2-THIONES ACTING AS ALPHA2 ADRENERGIC AGONISTS 审中-公开作为ALPHA2 ADRENERGIC AGONISTS的4-（异丁基 - 甲基和取代的杂芳基 - 甲基） - 咪唑-2-酮公开(公告)号：US20080221152A1
公开(公告)日：2008-09-11
申请号：US12123578
申请日：2008-05-20
申请人： Todd M. Heidelbaugh , Ken Chow , Phong X. Nguyen , Daniel W. Gil , John E. Donello , Michael E. Garst , Larry A. Wheeler
发明人： Todd M. Heidelbaugh , Ken Chow , Phong X. Nguyen , Daniel W. Gil , John E. Donello , Michael E. Garst , Larry A. Wheeler
IPC分类号： A61K31/437 , C07D403/06 , A61K31/4178 , A61K31/4439 , A61P25/00 , A61P25/30 , A61K31/4709 , C07D401/04 , C07D471/04
CPC分类号： C07D471/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06
摘要： Compounds of Formula 1 where the variables have the meaning defined in the specification are agonists of alpha2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors. Additionally some of the claimed compounds have no or only minimal cardiovascular and/or sedatory activity. The compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2 adrenergic receptors. Compounds of Formula 1 which have no significant cardiovascular and/or sedatory activity are useful for treating pain and other conditions with minimal side effects.
摘要翻译： 变量具有本说明书中定义的含义的式1化合物是α2肾上腺素能受体的激动剂。 本公开内容的若干化合物优先于α2A2肾上腺素能受体是特异性或选择性的α2B2和/或α2C2N2肾上腺素能受体。 另外一些要求保护的化合物没有或仅有最小的心血管和/或镇静活性。 式1的化合物可用作哺乳动物（包括人）中用作治疗疾病的药物和/或缓解通过α2肾上腺素能受体的激动剂治疗的病症。 没有明显的心血管和/或镇静作用的式1化合物可用于治疗疼痛和其他具有最小副作用的病症。
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27.发明申请METHODS AND COMPOSITIONS FOR MODULATING ALPHA ADRENERGIC RECEPTOR ACTIVITY 失效调节ALPHA ADRENERGIC受体活性的方法和组合物公开(公告)号：US20080132576A1
公开(公告)日：2008-06-05
申请号：US12024609
申请日：2008-02-01
申请人： Ken Chow , Daniel W. Gil , Wenkui Ken Fang , Michael E. Garst , Larry A. Wheeler
发明人： Ken Chow , Daniel W. Gil , Wenkui Ken Fang , Michael E. Garst , Larry A. Wheeler
CPC分类号： A61K31/17 , Y10S514/913
摘要： Methods and compositions for the treatment of pain and intraocular pressure. Particularly disclosed are new compositions for the treatment of chronic pain, glaucoma and methods for their use.
摘要翻译： 用于治疗疼痛和眼内压的方法和组合物。 特别公开了用于治疗慢性疼痛，青光眼的新组合物及其使用方法。
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28.发明授权2-((2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)methyl)-3,4-dihydronapthalen-1(2H)-one 有权2 - （（2-硫代-2,3-二氢-1H-咪唑-4-基）甲基）-3,4-二氢萘-1-（2H） - 酮公开(公告)号：US07358269B2
公开(公告)日：2008-04-15
申请号：US11368990
申请日：2006-03-06
IPC分类号： A61K31/4164 , C07D233/04
CPC分类号： C07D233/70 , A61K9/0019 , A61K31/4164 , C07D233/84 , C07D401/06 , C07D405/06 , C07D409/06 , C07D409/08
摘要： A compound of the formula or a pharmaceutically acceptable salt thereof, is disclosed herein. Methods and compositions related thereto are also disclosed.
摘要翻译： 本文公开了下式的化合物或其药学上可接受的盐。 还公开了与其相关的方法和组合物。
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公开(公告)号：US06329369B1
公开(公告)日：2001-12-11
申请号：US09679919
申请日：2000-10-05
申请人： Ken Chow , Daniel W. Gil , James A. Burke , Dale A. Harcourt , Michael E. Garst , Larry A. Wheeler , Stephen A. Munk
发明人： Ken Chow , Daniel W. Gil , James A. Burke , Dale A. Harcourt , Michael E. Garst , Larry A. Wheeler , Stephen A. Munk
IPC分类号： A61R314168
CPC分类号： C07D233/56 , C07D233/06 , C07D233/10 , C07D233/64 , C07D233/84 , C07D263/28 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/12 , C07D495/04 , Y10S514/816 , Y10S514/913
摘要： Methods of treating glaucoma or elevated pressure and other diseases with reduced side effects by treating a mammal in need thereof an agonist of the alpha 2B or alpha 2B/2C adrenergic receptor(s). Also described are compounds having such selective agonist activity.
摘要翻译： 通过用有需要的哺乳动物治疗α2B或α2B / 2C肾上腺素能受体的激动剂来治疗青光眼或升高压力的其它疾病及其副作用降低的方法。 还描述了具有这种选择性激动剂活性的化合物。
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公开(公告)号：US20090306398A1
公开(公告)日：2009-12-10
申请号：US12479256
申请日：2009-06-05
申请人： Wenkui K. Fang , Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Michael E. Garst , Santosh C. Sinha
发明人： Wenkui K. Fang , Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Michael E. Garst , Santosh C. Sinha
IPC分类号： C07D233/44
CPC分类号： A61K31/4168 , C07D233/48
摘要： Described herein are compounds for and methods of treating conditions or diseases in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an α-adrenergic modulator. The compounds and methods are also useful for alleviating types of pain, both acute and chronic.
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