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    Thiazolopyridine sirtuin modulating compounds
    23.
    发明授权
    Thiazolopyridine sirtuin modulating compounds 有权
    噻唑并吡啶沉默调节蛋白调节化合物

    公开(公告)号：US08343997B2

    公开(公告)日：2013-01-01

    申请号：US13139796

    申请日：2009-12-18

    申请人： Christopher Oalmann ,  Jeremy S. Disch ,  Pui Yee Ng ,  Robert Perni

    发明人： Christopher Oalmann ,  Jeremy S. Disch ,  Pui Yee Ng ,  Robert Perni

    IPC分类号： A61K31/429 ,  C07D513/04

    CPC分类号： C07D513/04 ,  A61K31/437 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06

    摘要： Provided herein are novel sirtuin-modulating compounds of Structural Formula (Ia) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

    摘要翻译： 本文提供了结构式（Ia）的新型沉默调节蛋白的调节性化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，血液凝固障碍，炎症，癌症和/或潮红以及将受益于增加的线粒体活性的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。

    THIAZOLOPYRIDINE SIRTUIN MODULATING COMPOUNDS
    24.
    发明申请
    THIAZOLOPYRIDINE SIRTUIN MODULATING COMPOUNDS 有权
    噻唑吡啶SIRTUIN调节化合物

    公开(公告)号：US20110306609A1

    公开(公告)日：2011-12-15

    申请号：US13139796

    申请日：2009-12-18

    申请人： Christopher Oalmann ,  Jeremy S. Disch ,  Pui Yee Ng ,  Robert Perni

    发明人： Christopher Oalmann ,  Jeremy S. Disch ,  Pui Yee Ng ,  Robert Perni

    IPC分类号： A61K31/5377 ,  A61P3/10 ,  A61K31/437 ,  C07D417/14 ,  A61K31/497

    CPC分类号： C07D513/04 ,  A61K31/437 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06

    摘要： Provided herein are novel sirtuin-modulating compounds of Structural Formula (Ia) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

    摘要翻译： 本文提供了结构式（Ia）的新型沉默调节蛋白的调节性化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，血液凝固障碍，炎症，癌症和/或潮红以及将受益于增加的线粒体活性的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。

    IMIDAZOPYRIDINE AND RELATED ANALOGS AS SIRTUIN MODULATORS
    26.
    发明申请
    IMIDAZOPYRIDINE AND RELATED ANALOGS AS SIRTUIN MODULATORS 审中-公开
    咪唑吡啶和相关模拟物作为SIRTUIN调节剂

    公开(公告)号：US20110077248A1

    公开(公告)日：2011-03-31

    申请号：US12993508

    申请日：2009-05-28

    申请人： Chi B. Vu ,  Pui Yee Ng ,  Charles A. Blum ,  Robert B. Perni

    发明人： Chi B. Vu ,  Pui Yee Ng ,  Charles A. Blum ,  Robert B. Perni

    IPC分类号： A61K31/5377 ,  C07D471/04 ,  A61K31/437 ,  A61K31/506 ,  A61K31/497 ,  A61K31/501 ,  A61P3/00 ,  A61P3/10

    CPC分类号： C07D471/04 ,  C07D487/04

    摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

    摘要翻译： 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，血液凝固障碍，炎症，癌症和/或潮红以及将受益于增加的线粒体活性的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。