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公开(公告)号：US20110124637A1
公开(公告)日：2011-05-26
申请号：US12999795
申请日：2009-07-02
申请人： Chi B Vu , Jeremy S. Disch , Pui Yee Ng , Charles A. Blum , Robert B. Perni
发明人： Chi B Vu , Jeremy S. Disch , Pui Yee Ng , Charles A. Blum , Robert B. Perni
IPC分类号： C07D417/12 , A61K31/427 , C07D417/14 , A61K31/496 , A61K31/5355 , C07D401/12 , A61K31/4439 , C07D413/14 , A61K31/454 , C07D403/12 , A61K31/4184 , C07D471/04 , A61K31/437 , C07D401/14 , C07D235/18 , C07D403/14 , C07D403/10 , A61K31/497 , C07D498/04 , A61K31/5365 , A61P3/00 , A61P3/10
CPC分类号： C07D513/04 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/437 , A61K31/439 , A61K31/4427 , A61K31/4439 , A61K31/46 , A61K31/495 , A61K31/497 , A61K31/5355 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04 , C07D471/08 , C07D498/04 , A61K2300/00
摘要： Provided herein are sirtuin-modulating compounds of formula (II). The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders relating to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
摘要翻译： 本文提供了式（II）的沉默调节蛋白的调节性化合物。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，血液凝固障碍，炎症，癌症和/或潮红以及将受益于增加的线粒体活性的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。
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公开(公告)号：US08846947B2
公开(公告)日：2014-09-30
申请号：US12999795
申请日：2009-07-02
申请人： Chi B. Vu , Jeremy S. Disch , Pui Yee Ng , Charles A. Blum , Robert B. Perni
发明人： Chi B. Vu , Jeremy S. Disch , Pui Yee Ng , Charles A. Blum , Robert B. Perni
IPC分类号： A61K31/4184 , A61K31/5377 , A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4545 , C07D235/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/5355 , C07D471/08 , C07D405/12 , A61K31/437 , C07D405/14 , A61K31/495 , A61K31/427 , A61K31/4427 , A61K45/06 , A61K31/422 , A61K31/46 , C07D513/04 , C07D471/04
CPC分类号： C07D513/04 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/437 , A61K31/439 , A61K31/4427 , A61K31/4439 , A61K31/46 , A61K31/495 , A61K31/497 , A61K31/5355 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04 , C07D471/08 , C07D498/04 , A61K2300/00
摘要： Provided herein are sirtuin-modulating compounds of formula (II). The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders relating to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
摘要翻译： 本文提供了式（II）的沉默调节蛋白的调节性化合物。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，血液凝固障碍，炎症，癌症和/或潮红以及将受益于增加的线粒体活性的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。
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公开(公告)号：US07893086B2
公开(公告)日：2011-02-22
申请号：US12214805
申请日：2008-06-20
申请人： Jean Bemis , Jeremy S. Disch , Pui Yee Ng , Christopher Oalmann , Robert B. Perni , Chi B. Vu
发明人： Jean Bemis , Jeremy S. Disch , Pui Yee Ng , Christopher Oalmann , Robert B. Perni , Chi B. Vu
IPC分类号： A01N43/42 , A01N43/78 , A01N43/26 , A01N43/06 , A61K31/44 , A61K31/425 , A61K31/385 , A61K31/38 , C07D471/02 , C07D491/02 , C07D513/02 , C07D515/02 , C07D417/00
CPC分类号： C07D513/04
摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
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公开(公告)号：US09556201B2
公开(公告)日：2017-01-31
申请号：US13504134
申请日：2010-10-29
申请人： Pui Yee Ng , Charles Blum , Lauren McPherson , Robert B. Perni , Chi B. Vu , Mohammed Mahmood Ahmed , Jeremy S. Disch
发明人： Pui Yee Ng , Charles Blum , Lauren McPherson , Robert B. Perni , Chi B. Vu , Mohammed Mahmood Ahmed , Jeremy S. Disch
IPC分类号： A61K31/55 , A61K31/551 , A61K31/553 , A61K31/4375 , A61K31/437 , A61K31/5365 , A61K31/4985 , C07D471/04 , C07D487/04 , C07D519/00 , C07D498/04
CPC分类号： C07D498/04 , C07D471/04
摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
摘要翻译： 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，血液凝固障碍，炎症，癌症和/或潮红以及将受益于增加的线粒体活性的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。
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公开(公告)号：US20120252780A1
公开(公告)日：2012-10-04
申请号：US13504134
申请日：2010-10-29
申请人： Pui Yee Ng , Charles Blum , Lauren McPherson , Robert B. Perni , Chi B. Vu , Mohammed Mahmood Ahmed , Jeremy S. Disch
发明人： Pui Yee Ng , Charles Blum , Lauren McPherson , Robert B. Perni , Chi B. Vu , Mohammed Mahmood Ahmed , Jeremy S. Disch
IPC分类号： A61K31/4375 , A61K31/5383 , C07D519/00 , C07D471/04 , A61P3/10 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/444 , A61P3/04 , C07D498/04 , A61K31/4985
CPC分类号： C07D498/04 , C07D471/04
摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
摘要翻译： 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，血液凝固障碍，炎症，癌症和/或潮红以及将受益于增加的线粒体活性的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。
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公开(公告)号：US20090105246A1
公开(公告)日：2009-04-23
申请号：US12214805
申请日：2008-06-20
申请人： Jean Bemis , Jeremy S. Disch , Pui Yee Ng , Christopher Oalmann , Robert B. Perni , Chi B. Vu
发明人： Jean Bemis , Jeremy S. Disch , Pui Yee Ng , Christopher Oalmann , Robert B. Perni , Chi B. Vu
IPC分类号： A61K31/5377 , C07D513/04 , A61K31/4365 , A61K31/496
CPC分类号： C07D513/04
摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
摘要翻译： 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，血液凝固障碍，炎症，癌症和/或潮红以及将受益于增加的线粒体活性的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。
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公开(公告)号：US08268862B2
公开(公告)日：2012-09-18
申请号：US13012775
申请日：2011-01-24
申请人： Jean Bemis , Jeremy S. Disch , Pui Yee Ng , Christopher Oalmann , Robert B. Perni , Chi B. Vu
发明人： Jean Bemis , Jeremy S. Disch , Pui Yee Ng , Christopher Oalmann , Robert B. Perni , Chi B. Vu
IPC分类号： A61K31/44 , A61K31/425 , A61K31/385 , A61K31/38
CPC分类号： C07D513/04
摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
摘要翻译： 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，血液凝固障碍，炎症，癌症和/或潮红以及将受益于增加的线粒体活性的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。
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公开(公告)号：US20110152254A1
公开(公告)日：2011-06-23
申请号：US13012775
申请日：2011-01-24
申请人： Jean Bemis , Jeremy S. Disch , Pui Yee Ng , Christopher Oalmann , Robert B. Perni , Chi B. Vu
发明人： Jean Bemis , Jeremy S. Disch , Pui Yee Ng , Christopher Oalmann , Robert B. Perni , Chi B. Vu
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4545 , A61K31/437 , A61K31/444 , A61K31/498 , A61K31/4709 , A61K31/506 , A61P3/00 , A61P3/10 , A61P5/50
CPC分类号： C07D513/04
摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
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公开(公告)号：US20110077248A1
公开(公告)日：2011-03-31
申请号：US12993508
申请日：2009-05-28
申请人： Chi B. Vu , Pui Yee Ng , Charles A. Blum , Robert B. Perni
发明人： Chi B. Vu , Pui Yee Ng , Charles A. Blum , Robert B. Perni
IPC分类号： A61K31/5377 , C07D471/04 , A61K31/437 , A61K31/506 , A61K31/497 , A61K31/501 , A61P3/00 , A61P3/10
CPC分类号： C07D471/04 , C07D487/04
摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
摘要翻译： 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，血液凝固障碍，炎症，癌症和/或潮红以及将受益于增加的线粒体活性的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。
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公开(公告)号：US08685970B2
公开(公告)日：2014-04-01
申请号：US12990339
申请日：2009-04-30
IPC分类号： A61K31/535 , C07D413/12 , C07D413/14
CPC分类号： C07D401/12 , C07D215/12 , C07D215/40 , C07D215/48 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04
摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
摘要翻译： 本文提供了新的沉默调节蛋白的调节化合物及其使用方法。 沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病， 心血管疾病，血液凝固障碍，炎症，癌症和/或潮红以及将受益于增加的线粒体活性的疾病或病症。 还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。
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