利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

50 条记录 (耗时 0.043 秒)

    Rationally designed polysaccharide lyases derived from chondroitinase B and methods of specifically cleaving therewith
    24.
    发明授权
    Rationally designed polysaccharide lyases derived from chondroitinase B and methods of specifically cleaving therewith 有权
    合理设计的衍生自软骨素酶B的多糖裂解酶和与其特异性切割的方法

    公开(公告)号：US07105334B2

    公开(公告)日：2006-09-12

    申请号：US10967041

    申请日：2004-10-14

    申请人： Kevin Pojasek ,  Rahul Raman ,  Ram Sasisekharan

    发明人： Kevin Pojasek ,  Rahul Raman ,  Ram Sasisekharan

    IPC分类号： C12N9/88 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

    CPC分类号： C08B37/0069 ,  A61K38/00 ,  C12N9/88 ,  C12Q1/527

    摘要： The invention relates to rationally designed polysaccharide lyases and uses thereof. In particular, the invention relates to modified chondroitinase B. The modified chondroitinase B enzymes of the invention are useful for a variety of purposes, including cleaving and sequencing polysaccharides such as glycosaminoglycans (GAGs) as well as removing polysaccharides from a solution. The invention also includes methods of inhibiting anticoagulant activity, inhibiting angiogenesis, treating cancer, and inhibiting maternal malarial infection.

    摘要翻译： 本发明涉及合理设计的多糖裂解酶及其用途。 特别地，本发明涉及修饰的软骨素酶B.本发明的修饰的软骨素酶B可用于多种目的，包括切割和测序多糖如糖胺聚糖（GAG），以及从溶液中除去多糖。 本发明还包括抑制抗凝血活性，抑制血管生成，治疗癌症和抑制产妇疟疾感染的方法。

    Chondroitinase ABC I polynucleotides
    26.
    发明授权
    Chondroitinase ABC I polynucleotides 有权
    软骨素酶ABC I多核苷酸

    公开(公告)号：US07553950B2

    公开(公告)日：2009-06-30

    申请号：US11638178

    申请日：2006-12-13

    申请人： Vikas Prabhakar ,  Ishan Capila ,  Rahul Raman ,  Carlos Bosques ,  Kevin Pojasek ,  Ram Sasisekharan

    发明人： Vikas Prabhakar ,  Ishan Capila ,  Rahul Raman ,  Carlos Bosques ,  Kevin Pojasek ,  Ram Sasisekharan

    IPC分类号： A61K31/70 ,  A61K38/47 ,  C12N9/88 ,  C12N9/24 ,  C12N15/70 ,  C07H21/04

    CPC分类号： C12N9/88 ,  A61K38/47 ,  Y02A50/411

    摘要： The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.

    摘要翻译： 本发明涉及软骨素酶ABCⅠ及其用途。 特别地，本发明涉及重组和修饰的软骨素酶ABCⅠ，其生产及其用途。 本发明的软骨素酶ABC I酶可用于多种目的，包括降解和分析多糖如糖胺聚糖（GAG）。 这些GAG可以包括硫酸软骨素，硫酸皮肤素，未硫酸化的软骨素和透明质酸。 软骨素酶ABC I酶也可用于促进神经再生，促进中风恢复，治疗脊髓损伤，治疗上皮疾病，治疗感染和治疗癌症等治疗方法。

    Recombinant chondroitinase ABC I and uses thereof
    27.
    发明授权
    Recombinant chondroitinase ABC I and uses thereof 有权
    重组软骨素酶ABCⅠ及其用途

    公开(公告)号：US07507570B2

    公开(公告)日：2009-03-24

    申请号：US11078915

    申请日：2005-03-10

    申请人： Vikas Prabhakar ,  Ishan Capila ,  Rahul Raman ,  Carlos Bosques ,  Kevin Pojasek ,  Ram Sasisekharan

    发明人： Vikas Prabhakar ,  Ishan Capila ,  Rahul Raman ,  Carlos Bosques ,  Kevin Pojasek ,  Ram Sasisekharan

    IPC分类号： C12N9/88 ,  C12N9/00 ,  C12N15/70 ,  C12Q1/68 ,  C12P19/28 ,  C12P21/06 ,  C07H21/04

    CPC分类号： C12N9/88 ,  A61K38/47 ,  Y02A50/411

    摘要： The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.

    摘要翻译： 本发明涉及软骨素酶ABCⅠ及其用途。 特别地，本发明涉及重组和修饰的软骨素酶ABCⅠ，其生产及其用途。 本发明的软骨素酶ABC I酶可用于多种目的，包括降解和分析多糖如糖胺聚糖（GAG）。 这些GAG可以包括硫酸软骨素，硫酸皮肤素，未硫酸化的软骨素和透明质酸。 软骨素酶ABC I酶也可用于促进神经再生，促进中风恢复，治疗脊髓损伤，治疗上皮疾病，治疗感染和治疗癌症等治疗方法。

    Method for analyzing polysaccharides
    29.
    发明授权
    Method for analyzing polysaccharides 有权
    多糖分析方法

    公开(公告)号：US07412332B1

    公开(公告)日：2008-08-12

    申请号：US09557997

    申请日：2000-04-24

    申请人： Ganesh Venkataraman ,  Zachary Shriver ,  Rahul Raman ,  Ram Sasisekharan ,  Nishla Keiser

    发明人： Ganesh Venkataraman ,  Zachary Shriver ,  Rahul Raman ,  Ram Sasisekharan ,  Nishla Keiser

    IPC分类号： G06F19/00

    CPC分类号： G06F19/703 ,  C07K1/00 ,  G06F19/28 ,  Y10S707/99936 ,  Y10S707/99943

    摘要： A data structure, tangibly embodied in a computer-readable medium, representing a polymer of chemical units is disclosed. The data structure includes an identifier including a plurality of fields for storing values corresponding to properties of the polymer. The polymer may, for example, be a polysaccharide and the chemical units may be saccharides. Also disclosed is a computer-implemented method for determining whether properties of a query sequence of chemical units match properties of a polymer of chemical units. The query sequence is represented by a first data structure, and the polymer is represented by a second data structure, each are tangibly embodied in a computer-readable medium, including an identifier including a plurality of bit fields for storing values corresponding to properties of the query sequence and polymer, respectively. The invention also involves a notational system referred to as Property Encoded Nomenclature.

    摘要翻译： 公开了一种有形地体现在表示化学单元的聚合物的计算机可读介质中的数据结构。 数据结构包括标识符，其包括用于存储与聚合物的性质对应的值的多个场。 聚合物可以是例如多糖，化学单元可以是糖。 还公开了一种用于确定化学单元的查询序列的属性是否与化学单元的聚合物的性质匹配的计算机实现的方法。 查询序列由第一数据结构表示，并且聚合物由第二数据结构表示，每个数据结构都有形地体现在计算机可读介质中，包括包括多个位字段的标识符，用于存储对应于 查询序列和聚合物。 本发明还涉及称为属性编码术语的符号系统。