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公开(公告)号：US08198449B2
公开(公告)日：2012-06-12
申请号：US12549983
申请日：2009-08-28
申请人： Richard Pracitto , John F. Kadow , John A. Bender , Brett R. Beno , Katharine A. Grant-Young , Ying Han , Piyasena Hewawasam , Andrew Nickel , Kyle E. Parcella , Kap-Sun Yeung , Louis S. Chupak
发明人： Richard Pracitto , John F. Kadow , John A. Bender , Brett R. Beno , Katharine A. Grant-Young , Ying Han , Piyasena Hewawasam , Andrew Nickel , Kyle E. Parcella , Kap-Sun Yeung , Louis S. Chupak
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/04 , C07D209/42 , C07D333/68 , C07D491/048
摘要： The disclosure provides compounds of formula I, II, III, IV, and V, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
摘要翻译： 本公开提供式I，II，III，IV和V的化合物，包括它们的盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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公开(公告)号：US20100184800A1
公开(公告)日：2010-07-22
申请号：US12720182
申请日：2010-03-09
申请人： Richard Pracitto , John F. Kadow , John A. Bender , Brett R. Beno , Katharine A. Grant-Young , Ying Han , Piyasena Hewawasam , Andrew Nickel , Kyle E. Parcella , Kap-Sun Yeung , Louis S. Chupak
发明人： Richard Pracitto , John F. Kadow , John A. Bender , Brett R. Beno , Katharine A. Grant-Young , Ying Han , Piyasena Hewawasam , Andrew Nickel , Kyle E. Parcella , Kap-Sun Yeung , Louis S. Chupak
IPC分类号： A61K31/437 , C07D471/04 , A61P31/14
CPC分类号： C07D209/42 , C07D333/68 , C07D471/04 , C07D491/048
摘要： The disclosure provides compounds of formula I, II, III, IV, and V, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
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公开(公告)号：US20100093694A1
公开(公告)日：2010-04-15
申请号：US12554193
申请日：2009-09-04
申请人： Kap-Sun Yeung , Kyle E. Parcella , John A. Bender , Brett R. Beno , Katharine A. Grant-Young , Ying Han , Piyasena Hewawasam , John F. Kadow , Andrew Nickel
发明人： Kap-Sun Yeung , Kyle E. Parcella , John A. Bender , Brett R. Beno , Katharine A. Grant-Young , Ying Han , Piyasena Hewawasam , John F. Kadow , Andrew Nickel
IPC分类号： A61K31/34 , C07D405/12 , A61K31/4196 , C07D405/14 , A61K31/444 , A61K31/505 , C07D413/12 , A61K31/5377 , C07D307/00
CPC分类号： C07D307/84 , C07D405/04 , C07D405/10 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/10 , C07D413/12 , C07D417/10 , C07D417/12 , C07D453/00 , C07D491/10
摘要： The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
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公开(公告)号：US08354410B2
公开(公告)日：2013-01-15
申请号：US13043747
申请日：2011-03-09
IPC分类号： A61K31/501 , A61K31/506 , A61K31/343 , A61K31/422 , A61K31/443 , C07D405/02 , C07D405/14 , C07D307/84 , C07D413/02
CPC分类号： C07D471/04 , C07D498/04
摘要： The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
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公开(公告)号：US08048887B2
公开(公告)日：2011-11-01
申请号：US12554193
申请日：2009-09-04
申请人： Kap-Sun Yeung , Kyle E. Parcella , John A. Bender , Brett R. Beno , Katharine A. Grant-Young , Ying Han , Piyasena Hewawasam , John F. Kadow , Andrew Nickel
发明人： Kap-Sun Yeung , Kyle E. Parcella , John A. Bender , Brett R. Beno , Katharine A. Grant-Young , Ying Han , Piyasena Hewawasam , John F. Kadow , Andrew Nickel
IPC分类号： A61K31/506 , C07D405/02
CPC分类号： C07D307/84 , C07D405/04 , C07D405/10 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/10 , C07D413/12 , C07D417/10 , C07D417/12 , C07D453/00 , C07D491/10
摘要： The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
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公开(公告)号：US20110256099A1
公开(公告)日：2011-10-20
申请号：US13166926
申请日：2011-06-23
申请人： Kap-Sun Yeung , Kyle E. Parcella , John A. Bender , Brett R. Beno , Katharine A. Grant-Young , Ying Han , Piyasena Hewawasam , John F. Kadow , Andrew Nickel
发明人： Kap-Sun Yeung , Kyle E. Parcella , John A. Bender , Brett R. Beno , Katharine A. Grant-Young , Ying Han , Piyasena Hewawasam , John F. Kadow , Andrew Nickel
CPC分类号： A61K31/506 , A61K45/06 , C07D307/84 , C07D405/04 , C07D405/10 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/10 , C07D413/12 , C07D417/10 , C07D417/12 , C07D453/00 , C07D491/10
摘要： The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
摘要翻译： 本公开提供式I化合物，包括其盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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公开(公告)号：US07541352B2
公开(公告)日：2009-06-02
申请号：US12022541
申请日：2008-01-30
IPC分类号： A61P31/00 , A61K31/55 , C07D223/14
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译： 本发明包括式I化合物以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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公开(公告)号：US07893055B2
公开(公告)日：2011-02-22
申请号：US11768458
申请日：2007-06-26
申请人： Michael A. Walker , Chen Li , Katharine A. Grant-Young , John D. Matiskella , B. Narasimhulu Naidu , Jacques Banville , Francis Beaulieu , Carl Ouellet , Annapurna Pendri , Roger Remillard , Yasutsugu Ueda , Ting T. Yin
发明人： Michael A. Walker , Chen Li , Katharine A. Grant-Young , John D. Matiskella , B. Narasimhulu Naidu , Jacques Banville , Francis Beaulieu , Carl Ouellet , Annapurna Pendri , Roger Remillard , Yasutsugu Ueda , Ting T. Yin
IPC分类号： A61P31/00 , A61K31/535 , C07D498/02
CPC分类号： C07D487/04 , C07D471/10 , C07D498/04
摘要： The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
摘要翻译： 本发明包括抑制HIV整合酶并防止病毒整合入人DNA的式I的系列双环嘧啶酮化合物。 这种作用使这些化合物可用于治疗艾滋病毒和艾滋病。 本发明还包括用于治疗感染HIV的那些的药物组合物和方法。
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公开(公告)号：US20080004265A1
公开(公告)日：2008-01-03
申请号：US11768458
申请日：2007-06-26
申请人： Michael A. Walker , Chen Li , Katharine A. Grant-Young , John D. Matiskella , B. Narasimhulu Naidu , Jacques Banville , Francis Beaulieu , Carl Ouellet , Annapurna Pendri , Roger Remillard , Yasutsugu Ueda , Ting T. Yin
发明人： Michael A. Walker , Chen Li , Katharine A. Grant-Young , John D. Matiskella , B. Narasimhulu Naidu , Jacques Banville , Francis Beaulieu , Carl Ouellet , Annapurna Pendri , Roger Remillard , Yasutsugu Ueda , Ting T. Yin
IPC分类号： A61K31/5383 , A61K31/4985 , A61P31/18 , C07D241/36 , C07D295/00 , C07D239/70 , A61K31/519
CPC分类号： C07D487/04 , C07D471/10 , C07D498/04
摘要： The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
摘要翻译： 本发明包括抑制HIV整合酶并防止病毒整合入人DNA的式I的系列双环嘧啶酮化合物。 这种作用使这些化合物可用于治疗艾滋病毒和艾滋病。 本发明还包括用于治疗感染HIV的那些的药物组合物和方法。
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公开(公告)号：US06875771B2
公开(公告)日：2005-04-05
申请号：US10620240
申请日：2003-07-15
IPC分类号： A61K31/519 , C07D471/04 , C07D471/14 , C07D487/02
CPC分类号： C07D471/04 , A61K31/519 , C07D471/14
摘要： Novel pyridopyrimidine derivatives which have a binding affinity for the human 5-HT6 receptor and, therefore, are useful in treating disorders responsive to antagonism of the 5-HT6 receptor such as psychosis, schizophrenia, manic depression, depression, neurological disorder, memory disorder, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease and Huntington's chorea.
摘要翻译： 对于人5-HT 6受体具有结合亲和力的新型吡啶并嘧啶衍生物，因此可用于治疗对5-HT 6受体拮抗作用的病症，例如精神病，精神分裂症，躁狂抑郁症，抑郁症，神经障碍，记忆障碍， 帕金森病，肌萎缩性侧索硬化，阿尔茨海默病和亨廷顿舞蹈病。
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