公开(公告)号：US06960590B2

公开(公告)日：2005-11-01

申请号：US10398851

申请日：2001-10-17

申请人： Mark E. Fraley ,  Shyam B. Karki ,  Yuntae Kim

发明人： Mark E. Fraley ,  Shyam B. Karki ,  Yuntae Kim

IPC分类号： A61K31/4709 ,  A61K31/496 ,  A61K31/551 ,  A61P3/10 ,  A61P9/00 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D401/04 ,  C07D401/14

CPC分类号： C07D401/04 ,  C07D401/14

摘要： The present invention relates to orally active salts of compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angio-genesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.

摘要翻译： 本发明涉及抑制，调节和/或调节酪氨酸激酶信号转导的化合物的口服活性盐，含有这些化合物的组合物及其用于治疗酪氨酸激酶依赖性疾病和病症如血管生成的方法， 癌症，肿瘤生长，动脉粥样硬化，年龄相关性黄斑变性，糖尿病性视网膜病变，炎症性疾病等。

公开(公告)号：US20180327374A1

公开(公告)日：2018-11-15

申请号：US15774157

申请日：2016-11-07

申请人： Michael T. RUDD ,  Edward J. BRNARDIC ,  Yuntae KIM ,  Robert S. MEISSNER ,  Vanessa RADA ,  Shawn J. STACHEL ,  Celina V. ZERBINATTI ,  Merck Sharp & Dohme Corp.

发明人： Michael T. Rudd ,  Edward J. Brnardic ,  Yuntae Kim ,  Robert S. Meissner ,  Vanessa L. Rada ,  Shawn J. Stachel ,  Celina V. Zerbinatti

IPC分类号： C07D295/16 ,  C07D243/08 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D487/08 ,  C07D513/04 ,  A61P25/28 ,  A61P25/18 ,  A61P25/16 ,  A61P3/10

CPC分类号： C07D295/16 ,  A61K31/496 ,  A61P3/10 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  C07D213/74 ,  C07D213/85 ,  C07D243/08 ,  C07D295/192 ,  C07D295/205 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/08 ,  C07D487/08 ,  C07D487/18 ,  C07D513/04 ,  C07D515/04

摘要： In its many embodiments, the present invention provides substituted cyanopyridine containing compounds of the Formula (I): and acceptable salts thereof, wherein R1, R2, R3, R4, R5, X, Y, Q, and the moiety are as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-β receptor (LXRβ) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.

公开(公告)号：US09165485B2

公开(公告)日：2015-10-20

申请号：US13611996

申请日：2012-09-12

申请人： Minsung Choi ,  Minsoo Kang ,  Moonju Kim ,  Miju Kim ,  Yuntae Kim ,  Soo-Ran Park ,  Sangchul Lee ,  Yong-Ju Jeong

发明人： Minsung Choi ,  Minsoo Kang ,  Moonju Kim ,  Miju Kim ,  Yuntae Kim ,  Soo-Ran Park ,  Sangchul Lee ,  Yong-Ju Jeong

IPC分类号： G02F1/1335 ,  G09F13/04 ,  G02F1/1333 ,  F21V8/00 ,  G06F1/16 ,  H04M1/02 ,  H04M1/22 ,  G06F1/32

CPC分类号： G09F13/04 ,  G02B6/0055 ,  G02B6/0088 ,  G02F1/133371 ,  G02F1/133555 ,  G02F2001/133627 ,  G02F2201/44 ,  G02F2201/58 ,  G02F2203/09 ,  G06F1/1616 ,  G06F1/1622 ,  G06F1/1624 ,  G06F1/3265 ,  H04M1/0214 ,  H04M1/0225 ,  H04M1/0235 ,  H04M1/0266 ,  H04M1/22 ,  H04M2250/16 ,  Y02D10/153

摘要： A display apparatus includes a backlight part including a backlight unit and a panel part including a display panel. The panel part is operated in a first state in which the display panel is substantially aligned with the backlight part or in a second state in which the display panel is not substantially aligned with the backlight part. The display panel receives the light from the backlight unit in the first state and receives an external light in the second state.

摘要翻译： 显示装置包括具有背光单元和包括显示面板的面板部的背光部。 面板部件在第一状态下操作，其中显示面板基本上与背光部分对准，或者在显示面板基本上不与背光部件对准的第二状态。 显示面板在第一状态下接收来自背光单元的光，并接收处于第二状态的外部光。

公开(公告)号：US20060290956A1

公开(公告)日：2006-12-28

申请号：US11186758

申请日：2005-07-22

申请人： Wonhee Choe ,  Yuntae Kim ,  Dongwoo Kang ,  Seongdeok Lee ,  Hyunwook Ok

发明人： Wonhee Choe ,  Yuntae Kim ,  Dongwoo Kang ,  Seongdeok Lee ,  Hyunwook Ok

IPC分类号： H04N1/60

CPC分类号： H04N1/6016 ,  H04N9/67

摘要： An apparatus and a method for converting a color signal and a computer-readable recording medium storing a computer program for controlling the apparatus. The apparatus converts an input color signal including first through mth input color components into an output color signal including first through nth (n>m) output color components. The apparatus includes: a combination extractor which extracts combinations for the first through nth output color components; a coefficient generator which generates a coefficient for representing the input color signal using the input color signal and the extracted combinations; a combination selector which selects desired combinations among the extracted combinations using the coefficient; and an output unit which generates the output color signal using the selected combinations.

摘要翻译： 用于转换彩色信号的装置和方法以及存储用于控制该装置的计算机程序的计算机可读记录介质。 该装置将包括第一至第m个输入颜色分量的输入颜色信号转换成包括第一至第n（n> m）个输出颜色分量的输出颜色信号。 该装置包括：组合提取器，其提取第一至第n个输出颜色分量的组合; 系数生成器，其使用输入的颜色信号和提取的组合生成用于表示输入的颜色信号的系数; 组合选择器，使用该系数选择提取的组合中的期望组合; 以及输出单元，其使用所选择的组合生成输出颜色信号。

公开(公告)号：US20130222730A1

公开(公告)日：2013-08-29

申请号：US13611996

申请日：2012-09-12

申请人： Minsung Choi ,  Minsoo Kang ,  Moonju Kim ,  Miju Kim ,  Yuntae Kim ,  Soo-Ran Park ,  Sangchul Lee ,  Yong-Ju Jeong

发明人： Minsung Choi ,  Minsoo Kang ,  Moonju Kim ,  Miju Kim ,  Yuntae Kim ,  Soo-Ran Park ,  Sangchul Lee ,  Yong-Ju Jeong

IPC分类号： G02F1/13357 ,  G09F13/04

CPC分类号： G09F13/04 ,  G02B6/0055 ,  G02B6/0088 ,  G02F1/133371 ,  G02F1/133555 ,  G02F2001/133627 ,  G02F2201/44 ,  G02F2201/58 ,  G02F2203/09 ,  G06F1/1616 ,  G06F1/1622 ,  G06F1/1624 ,  G06F1/3265 ,  H04M1/0214 ,  H04M1/0225 ,  H04M1/0235 ,  H04M1/0266 ,  H04M1/22 ,  H04M2250/16 ,  Y02D10/153

摘要： A display apparatus includes a backlight part including a backlight unit and a panel part including a display panel. The panel part is operated in a first state in which the display panel is substantially aligned with the backlight part or in a second state in which the display panel is not substantially aligned with the backlight part. The display panel receives the light from the backlight unit in the first state and receives an external light in the second state.

摘要翻译： 显示装置包括具有背光单元和包括显示面板的面板部的背光部。 面板部件在第一状态下操作，其中显示面板基本上与背光部分对准，或者在显示面板基本上不与背光部件对准的第二状态。 显示面板在第一状态下接收来自背光单元的光，并接收处于第二状态的外部光。

公开(公告)号：US20090275515A1

公开(公告)日：2009-11-05

申请号：US12442581

申请日：2007-10-15

申请人： Yuntae Kim ,  Robert S. Meissner ,  Helen J. Mitchell ,  James J. Perkins ,  Michael A. Rossi ,  Jiabing Wang

发明人： Yuntae Kim ,  Robert S. Meissner ,  Helen J. Mitchell ,  James J. Perkins ,  Michael A. Rossi ,  Jiabing Wang

IPC分类号： A61K31/44 ,  C07D213/56 ,  C07D409/12 ,  C07D401/12 ,  A61K31/4365 ,  A61K31/437 ,  A61P19/00 ,  A61K31/565 ,  A61K38/29 ,  A61K38/27 ,  A61K31/59 ,  A61P35/00

CPC分类号： C07D213/40 ,  C07D409/12

摘要： Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HFV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

摘要翻译： 结构式（I）的化合物是以组织选择性方式的雄激素受体（AR）的调节剂。 这些化合物可用于增强弱化肌张力和治疗由雄激素缺乏引起的疾病或可由雄激素给药改善的疾病，包括骨质疏松症，骨质减少，糖皮质激素诱导的骨质疏松症，牙周病，骨折，骨重建后的骨损伤 手术，肌肉减少症，虚弱，衰老皮肤，男性性腺机能减退，女性绝经后症状，动脉粥样硬化，高胆固醇血症，高脂血症，肥胖，再生障碍性贫血和其他造血障碍，炎性关节炎和关节修复，HFV消耗，前列腺癌，良性前列腺增生 ），腹部肥胖，代谢综合征，II型糖尿病，癌症恶病质，阿尔茨海默氏病，肌营养不良症，认知衰退，性功能障碍，睡眠呼吸暂停，抑郁症，卵巢早衰以及自身免疫性疾病，单独或与其它活性剂组合。

公开(公告)号：US10239849B2

公开(公告)日：2019-03-26

申请号：US15774157

申请日：2016-11-07

申请人： Merck Sharp & Dohme Corp. ,  Michael T. Rudd ,  Edward J. Brnardic ,  Yuntae Kim ,  Robert S. Meissner ,  Vanessa L. Rada ,  Shawn J. Stachel ,  Celina V. Zerbinatti

发明人： Michael T. Rudd ,  Edward J. Brnardic ,  Yuntae Kim ,  Robert S. Meissner ,  Vanessa L. Rada ,  Shawn J. Stachel ,  Celina V. Zerbinatti

IPC分类号： C07D243/08 ,  C07D295/16 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D487/08 ,  C07D513/04 ,  A61P25/18 ,  A61P25/16 ,  A61P25/28 ,  A61P3/10

摘要： In its many embodiments, the present invention provides substituted cyanopyridine containing compounds of the Formula (I): and acceptable salts thereof, wherein R1, R2, R3, R4, R5, X, Y, Q, and the moiety are as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-β receptor (LXRβ) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.

公开(公告)号：US07446902B2

公开(公告)日：2008-11-04

申请号：US11186758

申请日：2005-07-22

申请人： Wonhee Choe ,  Yuntae Kim ,  Dongwoo Kang ,  Seongdeok Lee ,  Hyunwook Ok

发明人： Wonhee Choe ,  Yuntae Kim ,  Dongwoo Kang ,  Seongdeok Lee ,  Hyunwook Ok

IPC分类号： G06F15/00 ,  G06K1/00 ,  H04N1/60 ,  H04N1/46

CPC分类号： H04N1/6016 ,  H04N9/67

摘要： An apparatus and a method for converting a color signal and a computer-readable recording medium storing a computer program for controlling the apparatus. The apparatus converts an input color signal including first through mth input color components into an output color signal including first through nth (n>m) output color components. The apparatus includes: a combination extractor which extracts combinations for the first through nth output color components; a coefficient generator which generates a coefficient for representing the input color signal using the input color signal and the extracted combinations; a combination selector which selects desired combinations among the extracted combinations using the coefficient; and an output unit which generates the output color signal using the selected combinations.

摘要翻译： 用于转换彩色信号的装置和方法以及存储用于控制该装置的计算机程序的计算机可读记录介质。 该装置将包括第一至第m个输入颜色分量的输入颜色信号转换成包括第一至第n（n> m）个输出颜色分量的输出颜色信号。 该装置包括：组合提取器，其提取第一至第n个输出颜色分量的组合; 系数生成器，其使用输入的颜色信号和提取的组合生成用于表示输入的颜色信号的系数; 组合选择器，使用该系数选择提取的组合中的期望组合; 以及输出单元，其使用所选择的组合生成输出颜色信号。

公开(公告)号：US20050096344A1

公开(公告)日：2005-05-05

申请号：US10900662

申请日：2004-07-28

申请人： Mark Fraley ,  Kenneth Arrington ,  Mark Bilodeau ,  George Hartman ,  William Hoffman ,  Yuntae Kim ,  Randall Hungate

发明人： Mark Fraley ,  Kenneth Arrington ,  Mark Bilodeau ,  George Hartman ,  William Hoffman ,  Yuntae Kim ,  Randall Hungate

IPC分类号： A61K31/495 ,  A61K45/06 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/02 ,  A61K31/4745 ,  C07D491/02 ,  C07D498/02

CPC分类号： C07D401/14 ,  A61K31/495 ,  A61K45/06 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  A61K2300/00

摘要： The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.