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    Carbonylamino-benzimidazole derivatives as androgen receptor modulators
    4.
    发明授权
    Carbonylamino-benzimidazole derivatives as androgen receptor modulators 失效
    羰基氨基 - 苯并咪唑衍生物作为雄激素受体调节剂

    公开(公告)号：US07622592B2

    公开(公告)日：2009-11-24

    申请号：US10533259

    申请日：2003-10-28

    申请人： Yuntae Kim ,  Barbara Hanney ,  Mark E. Duggan ,  Keith L. Spencer

    发明人： Yuntae Kim ,  Barbara Hanney ,  Mark E. Duggan ,  Keith L. Spencer

    IPC分类号： A61K31/427 ,  C07D417/04

    CPC分类号： C07D417/04 ,  C07D401/04 ,  C07D403/04 ,  C07D417/14

    摘要： Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and/or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, arthritic condition and joint repair, HIV-wasting, prostate cancer, cancer cachexia, Alzheimer s disease, muscular dystrophies, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

    摘要翻译： 结构式（I）的化合物是以组织选择性方式的雄激素受体（AR）的调节剂。 它们可用作骨和/或肌肉组织中雄激素受体的激动剂，同时拮抗男性患者的前列腺中或在女性患者的子宫中的AR。 因此，这些化合物可用于增强减弱的肌肉紧张度和治疗由雄激素缺乏引起的或由雄激素给药引起的疾病的治疗，包括骨质疏松症，骨质减少症，糖皮质激素诱导的骨质疏松症，牙周病，骨折，骨骼骨损伤 重建手术，肌肉减少症，脆弱性，皮肤老化，男性性腺机能减退，女性绝经后症状，动脉粥样硬化，高胆固醇血症，高脂血症，肥胖，再生障碍性贫血和其他造血障碍，关节炎病症和关节修复，艾滋病毒消耗，前列腺癌，癌症恶病质，阿尔茨海默病 疾病，肌营养不良，卵巢早衰，自身免疫疾病，单独或与其他活性剂组合。

    N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
    6.
    发明授权
    N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators 失效
    N-（2-苄基）-2-苯基丁酰胺作为雄激素受体调节剂

    公开(公告)号：US07268153B2

    公开(公告)日：2007-09-11

    申请号：US11145490

    申请日：2005-06-03

    申请人： Barbara Hanney ,  Yuntae Kim ,  Michael R. Krout ,  Robert S. Meissner ,  Helen J. Mitchell ,  Jeffrey Musselman ,  James J. Perkins ,  Jiabing Wang

    发明人： Barbara Hanney ,  Yuntae Kim ,  Michael R. Krout ,  Robert S. Meissner ,  Helen J. Mitchell ,  Jeffrey Musselman ,  James J. Perkins ,  Jiabing Wang

    IPC分类号： A61K31/165

    CPC分类号： C07D295/205 ,  C07C233/13 ,  C07C235/34 ,  C07C255/60 ,  C07C271/12 ,  C07C271/22 ,  C07C2601/02 ,  C07D213/61 ,  C07D213/73

    摘要： Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

    摘要翻译： 结构式I的化合物是以组织选择性方式的雄激素受体（AR）的调节剂。 这些化合物可用于增强弱化肌张力和治疗由雄激素缺乏引起的疾病或可由雄激素给药改善的疾病，包括骨质疏松症，骨质减少，糖皮质激素诱导的骨质疏松症，牙周病，骨折，骨重建后的骨损伤 手术，肌营养不良，虚弱，老化的皮肤，男性性腺机能减退，女性绝经后症状，动脉粥样硬化，高胆固醇血症，高脂血症，肥胖，再生障碍性贫血和其他造血障碍，炎性关节炎和关节修复，艾滋病毒消耗，前列腺癌，良性前列腺增生 ），腹部肥胖，代谢综合征，II型糖尿病，癌症恶病质，阿尔茨海默氏病，肌营养不良症，认知衰退，性功能障碍，睡眠呼吸暂停，抑郁症，卵巢早衰以及自身免疫性疾病，单独或与其它活性剂组合。

    Apparatus and method for converting color signal, and computer-readable recording medium for storing computer program for controlling the apparatus
    7.
    发明申请
    Apparatus and method for converting color signal, and computer-readable recording medium for storing computer program for controlling the apparatus 有权
    用于转换颜色信号的装置和方法，以及用于存储用于控制该装置的计算机程序的计算机可读记录介质

    公开(公告)号：US20060290956A1

    公开(公告)日：2006-12-28

    申请号：US11186758

    申请日：2005-07-22

    申请人： Wonhee Choe ,  Yuntae Kim ,  Dongwoo Kang ,  Seongdeok Lee ,  Hyunwook Ok

    发明人： Wonhee Choe ,  Yuntae Kim ,  Dongwoo Kang ,  Seongdeok Lee ,  Hyunwook Ok

    IPC分类号： H04N1/60

    CPC分类号： H04N1/6016 ,  H04N9/67

    摘要： An apparatus and a method for converting a color signal and a computer-readable recording medium storing a computer program for controlling the apparatus. The apparatus converts an input color signal including first through mth input color components into an output color signal including first through nth (n>m) output color components. The apparatus includes: a combination extractor which extracts combinations for the first through nth output color components; a coefficient generator which generates a coefficient for representing the input color signal using the input color signal and the extracted combinations; a combination selector which selects desired combinations among the extracted combinations using the coefficient; and an output unit which generates the output color signal using the selected combinations.

    摘要翻译： 用于转换彩色信号的装置和方法以及存储用于控制该装置的计算机程序的计算机可读记录介质。 该装置将包括第一至第m个输入颜色分量的输入颜色信号转换成包括第一至第n（n> m）个输出颜色分量的输出颜色信号。 该装置包括：组合提取器，其提取第一至第n个输出颜色分量的组合; 系数生成器，其使用输入的颜色信号和提取的组合生成用于表示输入的颜色信号的系数; 组合选择器，使用该系数选择提取的组合中的期望组合; 以及输出单元，其使用所选择的组合生成输出颜色信号。