公开(公告)号：US20090087850A1

公开(公告)日：2009-04-02

申请号：US12212313

申请日：2008-09-17

申请人： John Eid ,  Alex Dewinter

发明人： John Eid ,  Alex Dewinter

IPC分类号： C12Q1/68 ,  C12M1/00

CPC分类号： C12Q1/6869 ,  C12Q2521/319

摘要： Sequencing methods that use an exonuclease that comprises template dependent nucleobase binding activity are provided. Related compositions and sequencing systems are also provided.

摘要翻译： 提供了使用包含模板依赖性核碱基结合活性的外切核酸酶的测序方法。 还提供了相关的组合物和测序系统。

公开(公告)号：US20080176316A1

公开(公告)日：2008-07-24

申请号：US11981626

申请日：2007-10-31

申请人： John Eid ,  Devon Murphy ,  Geoffrey Otto ,  Stephen Turner

发明人： John Eid ,  Devon Murphy ,  Geoffrey Otto ,  Stephen Turner

IPC分类号： C12M1/40 ,  C12M1/34

CPC分类号： A61K38/446 ,  A61K38/063 ,  A61K38/443 ,  G01N33/582

摘要： Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.