-
1.发明申请公开(公告)号：US20110256631A1
公开(公告)日：2011-10-20
申请号：US13034199
申请日：2011-02-24
Applicant: Austin Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
Inventor： Austin Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
CPC classification number: C12Q1/6874 , C12Q1/6844 , C12Q1/686 , C12Q1/6869 , G01N21/6428 , G01N2021/6421 , G01N2021/6441 , G01N2201/06113 , G01N2201/12 , G06F19/22 , Y10T436/143333 , C12Q2563/107
Abstract: Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.
Abstract translation: 计算机实现的方法和执行这种方法的系统用于处理来自分析操作和系统的信号数据，特别是处理来自逐个引入过程的信号数据，以鉴定模板核酸和较大核酸分子的核苷酸序列，例如基因组或 片段。
-
公开(公告)号：US20110059505A1
公开(公告)日：2011-03-10
申请号：US12802591
申请日：2010-06-08
Applicant: David K. Hanzel , Geoff Otto , Devon Murphy , Paul Peluso , Thang Pham , David R. Rank , Paul Mitsis , Fred Christians , Arek Bibillo , Insil Park , Sonya Clark , John Lyle
Inventor： David K. Hanzel , Geoff Otto , Devon Murphy , Paul Peluso , Thang Pham , David R. Rank , Paul Mitsis , Fred Christians , Arek Bibillo , Insil Park , Sonya Clark , John Lyle
IPC: C12N9/12
CPC classification number: C12N9/1252 , C07K2319/20 , C12P19/34 , C12Q1/6827 , C12Q1/6869 , C12Y207/07007 , Y02P20/52
Abstract: Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
Abstract translation: 提供了包含具有改善核苷酸类似物进入活性位点区域并与活性位点区域中的核苷酸类似物配位的特征的聚合酶的组合物。 还提供了制备聚合酶和在测序和DNA复制和扩增中使用聚合酶的方法以及聚合酶活性的动力学模型和使用该模型的计算机实现的方法。
-
公开(公告)号：US20070196846A1
公开(公告)日：2007-08-23
申请号：US11645223
申请日：2006-12-21
Applicant: David Hanzel , Geoff Otto , Devon Murphy , Paul Peluso , Thang Pham , David Rank , Paul Mitsis
Inventor： David Hanzel , Geoff Otto , Devon Murphy , Paul Peluso , Thang Pham , David Rank , Paul Mitsis
CPC classification number: C12N9/1252 , C07K2319/20 , C12P19/34 , C12Q1/6827 , C12Q1/6869 , C12Y207/07007 , Y02P20/52
Abstract: Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
Abstract translation: 提供了包含具有改善核苷酸类似物进入活性位点区域并与活性位点区域中的核苷酸类似物配位的特征的聚合酶的组合物。 还提供了制备聚合酶和在测序和DNA复制和扩增中使用聚合酶的方法以及聚合酶活性的动力学模型和使用该模型的计算机实现的方法。
-
公开(公告)号：US08415128B2
公开(公告)日：2013-04-09
申请号：US13191256
申请日：2011-07-26
Applicant: John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
Inventor： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
IPC: C12N9/10
CPC classification number: A61K38/446 , A61K38/063 , A61K38/443 , G01N33/582
Abstract: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.
Abstract translation: 用于通过一种或多种在反应混合物中掺入光损伤缓和剂和/或在反应混合物中询问不同观察区域一段时间来减少和/或防止一种或多种反应物在照明分析反应中的光损伤的组合物，装置，系统和方法 这小于光损伤阈值期。
-
公开(公告)号：US08071346B2
公开(公告)日：2011-12-06
申请号：US11981626
申请日：2007-10-31
Applicant: John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
Inventor： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
IPC: C12N9/96
CPC classification number: A61K38/446 , A61K38/063 , A61K38/443 , G01N33/582
Abstract: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.
Abstract translation: 用于通过一种或多种在反应混合物中掺入光损伤缓和剂和/或在反应混合物中询问不同观察区域一段时间来减少和/或防止一种或多种反应物在照明分析反应中的光损伤的组合物，装置，系统和方法 这小于光损伤阈值期。
-
Patent Agency Ranking
公开(公告)号：US07993895B2
公开(公告)日：2011-08-09
申请号：US11566153
申请日：2006-12-01
Applicant: John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
Inventor： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
IPC: C12N9/10
CPC classification number: A61K38/446 , A61K38/063 , A61K38/443 , G01N33/582
Abstract: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.
Abstract translation: 用于通过一种或多种在反应混合物中掺入光损伤缓和剂和/或在反应混合物中询问不同观察区域一段时间来减少和/或防止一种或多种反应物在照明分析反应中的光损伤的组合物，装置，系统和方法 这小于光损伤阈值期。
-
公开(公告)号：US20080176316A1
公开(公告)日：2008-07-24
申请号：US11981626
申请日：2007-10-31
Applicant: John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
Inventor： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
CPC classification number: A61K38/446 , A61K38/063 , A61K38/443 , G01N33/582
Abstract: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.
-
公开(公告)号：US20120028250A1
公开(公告)日：2012-02-02
申请号：US13191256
申请日：2011-07-26
Applicant: John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
Inventor： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
CPC classification number: A61K38/446 , A61K38/063 , A61K38/443 , G01N33/582
Abstract: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.
Abstract translation: 用于通过一种或多种在反应混合物中掺入光损伤缓和剂和/或在反应混合物中询问不同观察区域一段时间来减少和/或防止一种或多种反应物在照明分析反应中的光损伤的组合物，装置，系统和方法 这小于光损伤阈值期。
-
公开(公告)号：US07998717B2
公开(公告)日：2011-08-16
申请号：US11293040
申请日：2005-12-02
Applicant: John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
Inventor： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
IPC: C12N9/10
CPC classification number: A61K38/446 , A61K38/063 , A61K38/443 , G01N33/582
Abstract: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.
-
10.发明申请公开(公告)号：US20090024331A1
公开(公告)日：2009-01-22
申请号：US12134186
申请日：2008-06-05
Applicant: Austin B. Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
Inventor： Austin B. Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
CPC classification number: C12Q1/6869 , G06F19/22 , C12Q2563/107
Abstract: Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.
Abstract translation: 计算机实现的方法和执行这种方法的系统用于处理来自分析操作和系统的信号数据，特别是处理来自逐个引入过程的信号数据，以鉴定模板核酸和较大核酸分子的核苷酸序列，例如基因组或 片段。
-
-
-
-
-
-
-
-
-
Search Results
15
records
(took 0.021 seconds)
