公开(公告)号：US20070048264A1

公开(公告)日：2007-03-01

申请号：US11539479

申请日：2006-10-06

申请人： Wayne Kindsvogel ,  Steven Hughes ,  Richard Holly ,  Christopher Clegg ,  Donald Foster ,  Rebecca Johnson ,  Mark Heipel ,  Pallavur Sivakumar

发明人： Wayne Kindsvogel ,  Steven Hughes ,  Richard Holly ,  Christopher Clegg ,  Donald Foster ,  Rebecca Johnson ,  Mark Heipel ,  Pallavur Sivakumar

IPC分类号： A61K38/20 ,  A61K39/395

CPC分类号： C07K16/32 ,  A61K38/20 ,  A61K39/395 ,  A61K39/39558 ,  C07K16/2818 ,  C07K16/2896 ,  C07K2317/732 ,  A61K2300/00

摘要： Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.

公开(公告)号：US20070048265A1

公开(公告)日：2007-03-01

申请号：US11539523

申请日：2006-10-06

申请人： Pallavur Sivakumar ,  Andrew Nelson

发明人： Pallavur Sivakumar ,  Andrew Nelson

IPC分类号： A61K38/20

CPC分类号： A61K38/20

摘要： Administration of IL-21 results in decreasing autoimmune responses and thereby provides a beneficial treatment for autoimmune diseases. Specific autoimmune diseases that may be treated include multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, psoriasis, ankylosing spondilitis, scleroderma, Type I diabetes, psoriatic arthritis, osteoarthritis, inflammatory bowel disease, atopic dermatitis and asthma. Pharmaceutical compositions can include IL-21 polypeptides and active fragments thereof.

摘要翻译： IL-21的施用导致自身免疫反应降低，从而为自身免疫性疾病提供有益的治疗。 可以治疗的特异性自身免疫性疾病包括多发性硬化，类风湿性关节炎，系统性红斑狼疮，牛皮癣，强直性脊柱炎，硬皮病，I型糖尿病，牛皮癣关节炎，骨关节炎，炎症性肠病，特应性皮炎和哮喘。 药物组合物可以包括IL-21多肽及其活性片段。

公开(公告)号：US20050095223A1

公开(公告)日：2005-05-05

申请号：US10951239

申请日：2004-09-27

申请人： Pallavur Sivakumar ,  Andrew Nelson

发明人： Pallavur Sivakumar ,  Andrew Nelson

IPC分类号： A61K38/20 ,  C12P21/04

CPC分类号： A61K38/20

摘要： Administration of IL-21 results in decreasing autoimmune responses and thereby provides a beneficial treatment for autoimmune diseases. Specific autoimmune diseases that may be treated include multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, psoriasis, ankylosing spondilitis, scleroderma, Type I diabetes, psoriatic arthritis, osteoarthritis, inflammatory bowel disease, atopic dermatitis and asthma. Pharmaceutical compositions can include IL-21 polypeptides and active fragments thereof.

摘要翻译： IL-21的施用导致自身免疫反应降低，从而为自身免疫性疾病提供有益的治疗。 可以治疗的特异性自身免疫性疾病包括多发性硬化，类风湿性关节炎，系统性红斑狼疮，牛皮癣，强直性脊柱炎，硬皮病，I型糖尿病，牛皮癣关节炎，骨关节炎，炎症性肠病，特应性皮炎和哮喘。 药物组合物可以包括IL-21多肽及其活性片段。

公开(公告)号：US20070122413A1

公开(公告)日：2007-05-31

申请号：US11563928

申请日：2006-11-28

申请人： Pallavur Sivakumar ,  Stephen Jaspers

发明人： Pallavur Sivakumar ,  Stephen Jaspers

IPC分类号： A61K39/395 ,  C07K16/24 ,  C12P21/08 ,  C12N5/06

CPC分类号： C07K16/244 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/30 ,  Y10S530/809

摘要： Monoclonal antibodies are identified that bind the IL-21 protein. These antibodies are used to identify regions of the IL-21 protein to where binding neutralizes IL-21 activity. Hybridomas and methods of producing anti-IL-21 monoclonal antibodies are described. The monoclonal antibodies are useful in treating IL-21-mediated diseases, which may include autoimmune and inflammatory diseases such as pancreatitis, type I diabetes (IDDM), Graves Disease, inflammatory bowel disease (IBD), Crohn's Disease, ulcerative colitis, irritable bowel syndrome, multiple sclerosis, rheumatoid arthritis, diverticulosis, systemic lupus erythematosus, psoriasis, ankylosing spondylitis, scleroderma, systemic sclerosis, psoriatic arthritis, osteoarthritis, atopic dermatitis, vitiligo, graft vs. host disease (GVHD), cutaneous T cell lymphoma (CTCL), Sjogren's syndrome, glomerulonephritis, IgA nephropathy, graft versous host disease, transplant rejection, atopic dermatitis, anti-phospholipid syndrome, and asthma, and other autoimmune diseases.

摘要翻译： 鉴定结合IL-21蛋白的单克隆抗体。 这些抗体用于鉴定结合中和IL-21活性的IL-21蛋白的区域。 描述了杂交瘤和产生抗IL-21单克隆抗体的方法。 单克隆抗体可用于治疗IL-21介导的疾病，其可能包括自身免疫性和炎性疾病如胰腺炎，I型糖尿病（IDDM），格雷夫斯病，炎性肠病（IBD），克罗恩病，溃疡性结肠炎，肠易激综合征 综合征，多发性硬化症，类风湿性关节炎，憩室病，系统性红斑狼疮，牛皮癣，强直性脊柱炎，硬皮病，系统性硬化症，牛皮癣关节炎，骨关节炎，特应性皮炎，白癜风，移植物抗宿主病（GVHD），皮肤T细胞淋巴瘤（CTCL） ，干燥综合征，肾小球肾炎，IgA肾病，移植物宿主病，移植排斥反应，特应性皮炎，抗磷脂综合征，哮喘和其他自身免疫性疾病。

公开(公告)号：US20080025946A1

公开(公告)日：2008-01-31

申请号：US11777852

申请日：2007-07-13

申请人： Pallavur Sivakumar ,  Diana Hausman ,  Steven Hughes ,  Eric Sievers ,  Dennis Miller

发明人： Pallavur Sivakumar ,  Diana Hausman ,  Steven Hughes ,  Eric Sievers ,  Dennis Miller

IPC分类号： A61K38/20 ,  A61K31/44 ,  A61P35/00

CPC分类号： A61K45/06 ,  A61K31/404 ,  A61K31/4412 ,  A61K38/20 ,  A61K2300/00

摘要： The present invention provides methods for use of IL-21 in combination with a tyrosine kinase inhibitor (TKI) in treatment of diseases in which inhibition of phosphorylation via TK inhibition and modulation of immune function play a clinically beneficial role. These diseases include, but are not limited to, cancers, such as renal cell carcinoma and metastatic melanoma.

摘要翻译： 本发明提供了将IL-21与酪氨酸激酶抑制剂（TKI）组合用于治疗通过TK抑制和调节免疫功能的磷酸化抑制发挥临床有益作用的疾病的方法。 这些疾病包括但不限于癌症，例如肾细胞癌和转移性黑素瘤。

公开(公告)号：US20070128189A1

公开(公告)日：2007-06-07

申请号：US11564001

申请日：2006-11-28

申请人： Pallavur Sivakumar ,  Stephen Jaspers

发明人： Pallavur Sivakumar ,  Stephen Jaspers

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C12N5/06 ,  C07K16/28

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K16/244 ,  C07K2317/76 ,  C07K2319/30 ,  Y10S530/809

摘要： Monoclonal antibodies to the IL-21 receptor and multimeric complexes comprising the IL-21 receptor; including monoclonal antibodies to the heterodimeric receptor, IL-21/IL-2Rγ; have been prepared. The invention also describes a method of producing said antibodies. And, the invention also describes a method of treatment comprising using said antibodies to suppress an immune response.

摘要翻译： IL-21受体的单克隆抗体和包含IL-21受体的多聚复合物; 包括针对异二聚体受体的单克隆抗体，IL-21 / IL-2Rγ; 已经准备好了 本发明还描述了产生所述抗体的方法。 而且，本发明还描述了一种包括使用所述抗体抑制免疫应答的治疗方法。