公开(公告)号：US07179908B2

公开(公告)日：2007-02-20

申请号：US10363468

申请日：2002-07-03

申请人： Kimoon Kim ,  Jianzhang Zhao ,  Hee-Joon Kim ,  Soo-Young Kim ,  Jinho Oh

发明人： Kimoon Kim ,  Jianzhang Zhao ,  Hee-Joon Kim ,  Soo-Young Kim ,  Jinho Oh

IPC分类号： C07D487/22

CPC分类号： C07D487/08 ,  C07D487/22

摘要： Provided are cucurbituril derivatives having the formula (1), their preparation methods and uses: where X is O, S or NH; R1 and R2 are each independently selected from the group consisting of hydrogen, alkyl groups of 1 to 30 carbon atoms, alkenyl groups of 1 to 30 carbon atoms, alkynyl groups of 1 to 30 carbon atoms, alkylthio groups of 1 to 30 carbon atoms, alkylcarboxyl groups of 1 to 30 carbon atoms, hydroxyalkyl groups of 1 to 30 carbon atoms, alkylsilyl groups of 1 to 30 carbon atoms, alkoxy groups of 1 to 30 carbon atoms, haloalkyl groups of 1 to 30 carbon atoms, nitro group, alkylamine groups of 1 to 30 carbon atoms, amine group, aminoalkyl groups of 1 to 30 carbon atoms, unsubstituted cycloalkyl groups of 5 to 30 carbon atoms, cycloalkyl groups of 4 to 30 carbon atoms with hetero atoms, unsubstituted aryl groups of 6 to 30 carbon atoms, and aryl groups of 6 to 30 carbon atoms with hetero atoms; and n and m are independently integers from 4 to 20 and from 1 to 7, respectively. The cucurbituril derivative has enhanced solubility in common solvents, thereby providing wider applications.

摘要翻译： 提供具有式（1）的葫芦巴衍生物，其制备方法和用途：其中X是O，S或NH; R 1和R 2各自独立地选自氢，1〜30个碳原子的烷基，1〜30个碳原子的烯基，炔基 1〜30个碳原子的烷硫基，1〜30个碳原子的烷基羧基，1〜30个碳原子的羟基烷基，1〜30个碳原子的烷基甲硅烷基，1〜30个碳原子的烷氧基 1〜30个碳原子的卤代烷基，硝基，1〜30个碳原子的烷基胺基，1〜30个碳原子的氨基烷基，5〜30个碳原子的未取代环烷基，4〜 具有杂原子的30个碳原子，6至30个碳原子的未取代的芳基和6至30个碳原子的具有杂原子的芳基; 并且n和m分别独立地为4至20和1至7的整数。 葫芦巴衍生物在常用溶剂中具有增强的溶解性，从而提供更广泛的应用。

公开(公告)号：US06639069B2

公开(公告)日：2003-10-28

申请号：US10092468

申请日：2002-03-08

申请人： Kimoon Kim ,  Jaheon Kim ,  In-Sun Jung ,  Soo-Young Kim ,  Eunsung Lee ,  Jin-Koo Kang

发明人： Kimoon Kim ,  Jaheon Kim ,  In-Sun Jung ,  Soo-Young Kim ,  Eunsung Lee ,  Jin-Koo Kang

IPC分类号： C07D24504

CPC分类号： C07D245/04 ,  B01D53/34 ,  B01D53/50 ,  B01D53/56 ,  B01D53/62 ,  B01J31/0237 ,  B01J31/0247 ,  B01J31/0249 ,  B01J31/0251 ,  C02F1/58 ,  C07D487/22 ,  Y02C10/08

摘要： Cucurbituril derivatives, their preparation methods and uses. The cucurbituril derivatives have the formula (1) where X is O, S or NH; R1 and R2 are independently selected from the group consisting of hydrogen, alkyl groups of 1 to 30 carbon atoms, alkenyl groups of 1 to 30 carbon atoms, alkynyl groups of 1 to 30 carbon atoms, alkylthio groups of 1 to 30 carbon atoms, alkylcarboxyl groups of 1 to 30 carbon atoms, hydroxyalkyl groups of 1 to 30 carbon atoms, alkylsilyl groups of 1 to 30 carbon atoms, alkoxy groups of 1 to 30 carbon atoms, haloalkyl groups of 1 to 30 carbon atoms, nitro group, alkylamine groups of 1 to 30 carbon atoms, amine group, aminoalkyl groups of 1 to 30 carbon atoms, unsubstituted cycloalkyl groups of 5 to 30 carbon atoms, cycloalkyl groups of 4 to 30 carbon atoms with hetero atoms, unsubstituted aryl groups of 6 to 30 carbon atoms, and aryl groups of 6 to 30 carbon atoms with hetero atoms; and n is an integer from 4 to 20, wherein the cucurbituril derivatives having the formula (1), where n=6, R1=H, R2=H and X=O, and n=5, R1=CH3, R2=H and X=O, are excluded. The cucurbituril derivatives are easily prepared as a mixture by one of the three new methods, and each cucurbituril derivative can be separated from the mixture by fractional crystallization. The cucurbituril derivatives having the formula (1) or their mixtures are very useful in removing dyes and heavy metal ions dissolved in water or waste water.

摘要翻译： 葫芦素衍生物，其制备方法和用途。 葫芦巴衍生物具有式（1）其中X是O，S或NH; R1和R2独立地选自氢，1〜30个碳原子的烷基，1〜30个碳原子的烯基，1〜30个碳原子的炔基，1〜30个碳原子的烷硫基，烷基羧基 1〜30个碳原子的基团，1〜30个碳原子的羟基烷基，1〜30个碳原子的烷基甲硅烷基，1〜30个碳原子的烷氧基，1〜30个碳原子的卤代烷基，硝基， 1至30个碳原子，胺基，1至30个碳原子的氨基烷基，5至30个碳原子的未取代环烷基，4至30个碳原子的杂原子环烷基，6至30个碳原子的未取代芳基， 和具有6-10个碳原子的杂原子的芳基; n为4〜20的整数，式中，n = 6，R1 = H，R2 = H，X = O，n = 5，R1 = CH3，R2 = H的葫芦巴脲衍生物 和X = O。 通过三种新方法之一容易地制备葫芦巴脲衍生物作为混合物，并且可以通过分级结晶从混合物中分离出每种葫芦巴脲衍生物。 具有式（1）的葫芦巴衍生物或其混合物非常适用于去除溶于水或废水中的染料和重金属离子。

公开(公告)号：US08002987B2

公开(公告)日：2011-08-23

申请号：US12092663

申请日：2006-03-24

申请人： Kimoon Kim ,  Kyeng-Min Park ,  Young-Ho Ko ,  Narayanan Selvapalam ,  Erumaipatty R Nagarajan

发明人： Kimoon Kim ,  Kyeng-Min Park ,  Young-Ho Ko ,  Narayanan Selvapalam ,  Erumaipatty R Nagarajan

IPC分类号： B01D15/08

CPC分类号： C07D487/04 ,  B01J20/286 ,  C07D305/14

摘要： Provided are a stationary phase and a column using a cucurbituril-bound silica gel, and a method of separating taxane using the column. The taxane separation method includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represented by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formula 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; applying the taxane-containing solution to the column; supplying a mobile-phase solvent to the column to obtain a taxane extract from the column; and purifying taxane from the taxane extract. Therefore, highly purified taxane can be separated from a low-purity crude taxane extract.

摘要翻译： 提供了使用葫芦巴结合的硅胶的固定相和柱，以及使用该柱分离紫杉烷的方法。 紫杉烷分离方法包括：制备紫杉烷分离柱，该柱用包含葫芦素结合硅胶的固定相填充，其中由式1或2表示的葫芦巴与由式3表示的改性硅胶共价结合 ; 将紫杉烷粉末溶解在溶剂中以制备含紫杉烷的溶液; 将含有紫杉烷的溶液应用于色谱柱; 向柱中提供流动相溶剂以从柱中获得紫杉烷提取物; 并从紫杉烷提取物中纯化紫杉烷。 因此，高纯度的紫杉烷可以与低纯度的紫杉烷提取物分离。

公开(公告)号：US20100281957A1

公开(公告)日：2010-11-11

申请号：US12514280

申请日：2007-10-25

申请人： Yoshihisa Inoue ,  Mikhail Rekharsky ,  Kimoon Kim ,  Yong Ho Ko ,  Narayanan Selvapalam

发明人： Yoshihisa Inoue ,  Mikhail Rekharsky ,  Kimoon Kim ,  Yong Ho Ko ,  Narayanan Selvapalam

IPC分类号： G01N33/68 ,  G01N25/00

CPC分类号： C07K14/575 ,  G01N33/6818 ,  Y02P20/55 ,  Y10S436/815

摘要： The present invention provides a method for determining in a pharmaceutical test formulation the presence or absence of a peptide compound PYY3-36 represented by the following amino acid sequence: H-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-X (SEQ ID NO: 1), wherein X is OH or a carboxy acid-protecting group, the method comprising (1) preparing a solution by mixing the pharmaceutical test formulation with cucurbit[7]uril in a solvent; and (2) thermally analyzing the solution prepared in Step (1).

公开(公告)号：US20100010215A1

公开(公告)日：2010-01-14

申请号：US11989200

申请日：2006-07-24

申请人： Lyle David Isaacs ,  Simin Liu ,  Kimoon Kim ,  Sang-Kyu Park ,  Young Ho Ko ,  Hyunuk Kim ,  Youngkook Kim ,  Narayanan Selvapalam

发明人： Lyle David Isaacs ,  Simin Liu ,  Kimoon Kim ,  Sang-Kyu Park ,  Young Ho Ko ,  Hyunuk Kim ,  Youngkook Kim ,  Narayanan Selvapalam

IPC分类号： C07D487/22

CPC分类号： C07D487/22

摘要： Inverted cucurbituril compounds having at least one pair of hydrogen atoms protruding into an internal molecular cavity thereof.

摘要翻译： 具有突出到其内部分子腔中的至少一对氢原子的倒置的葫芦素化合物。

公开(公告)号：US20080290028A1

公开(公告)日：2008-11-27

申请号：US12092663

申请日：2006-03-24

申请人： Kimoon Kim ,  Young-Ho Ko ,  Kyeng-Min Park ,  Narayanan Selvapalam ,  Erumaipatty R. Nagarajan

发明人： Kimoon Kim ,  Young-Ho Ko ,  Kyeng-Min Park ,  Narayanan Selvapalam ,  Erumaipatty R. Nagarajan

IPC分类号： B01D15/08

CPC分类号： C07D487/04 ,  B01J20/286 ,  C07D305/14

摘要： Provided are a stationary phase and a column using a cucurbituril-bound silica gel, and a method of separating taxane using the column. The taxane separation method includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represented by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formula 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; applying the taxane-containing solution to the column; supplying a mobile-phase solvent to the column to obtain a taxane extract from the column; and purifying taxane from the taxane extract. Therefore, highly purified taxane can be separated from a low-purity crude taxane extract.

摘要翻译： 提供了使用葫芦巴结合的硅胶的固定相和柱，以及使用该柱分离紫杉烷的方法。 紫杉烷分离方法包括：制备紫杉烷分离柱，该柱用包含葫芦素结合硅胶的固定相填充，其中由式1或2表示的葫芦巴与由式3表示的改性硅胶共价结合 ; 将紫杉烷粉末溶解在溶剂中以制备含紫杉烷的溶液; 将含紫杉烷的溶液应用于色谱柱; 向柱中提供流动相溶剂以从柱中获得紫杉烷提取物; 并从紫杉烷提取物中纯化紫杉烷。 因此，高纯度的紫杉烷可以与低纯度的紫杉烷提取物分离。

公开(公告)号：US20080139821A1

公开(公告)日：2008-06-12

申请号：US10598861

申请日：2004-03-13

申请人： Kimoon Kim ,  Jae Wook Lee ,  Dong Hyun Oh ,  Jeongmin Ju

发明人： Kimoon Kim ,  Jae Wook Lee ,  Dong Hyun Oh ,  Jeongmin Ju

IPC分类号： C07D235/02

CPC分类号： C07D487/22

摘要： Provided are a disubstituted cucurbituril that can be easily substituted by a substituent according to a desired usage and a method for preparing the same. The disubstituted cucurbituril has two end functional groups that can covalently bind with a solid substrate or a biochemically useful compound to obtain a cucurbituril-bonded substrate, which enables application of the disubstituted cucurbituril as column packing materials for chromatography, additives to gas separation membranes, catalysts for various chemical reactions, chemical sensors, or biological sensors.

摘要翻译： 本发明提供可以根据期望的用途容易地被取代基取代的二取代的葫芦巴脲及其制备方法。 二取代的葫芦巴具有两个可与固体底物或生物化学有用的化合物共价结合的末端官能团，以获得葫芦素键合的底物，其可以应用二取代的葫芦素作为色谱柱的填充材料，气体分离膜的添加剂，催化剂 用于各种化学反应，化学传感器或生物传感器。

公开(公告)号：US07160466B2

公开(公告)日：2007-01-09

申请号：US10646722

申请日：2003-08-25

申请人： Kimoon Kim ,  Jaheon Kim ,  In-Sun Jung ,  Soo-Young Kim ,  Eunsung Lee ,  Jin-Koo Kang

发明人： Kimoon Kim ,  Jaheon Kim ,  In-Sun Jung ,  Soo-Young Kim ,  Eunsung Lee ,  Jin-Koo Kang

IPC分类号： C02F1/58 ,  C02F1/62

CPC分类号： C07D245/04 ,  B01D53/34 ,  B01D53/50 ,  B01D53/56 ,  B01D53/62 ,  B01J31/0237 ,  B01J31/0247 ,  B01J31/0249 ,  B01J31/0251 ,  C02F1/58 ,  C07D487/22 ,  Y02C10/08

摘要： Uses of cucurbituril derivatives are disclosed. The cucurbituril derivatives have the formula (1) where X is O, S or NH; R1 and R2 are independently selected from the group consisting of hydrogen, alkyl groups of 1 to 30 carbon atoms, alkenyl groups of 1 to 30 carbon atoms, alkynyl groups of 1 to 30 carbon atoms, alkylthio groups of 1 to 30 carbon atoms, alkylcarboxyl groups of 1 to 30 carbon atoms, hydroxyalkyl groups of 1 to 30 carbon atoms, alkylsilyl groups of 1 to 30 carbon atoms, alkoxy groups of 1 to 30 carbon atoms, haloalkyl groups of 1 to 30 carbon atoms, nitro group, alkylamine groups of 1 to 30 carbon atoms, amine group, aminoalkyl groups of 1 to 30 carbon atoms, unsubstituted cycloalkyl groups of 5 to 30 carbon atoms, cycloalkyl groups of 4 to 30 carbon atoms with hetero atoms, unsubstituted aryl groups of 6 to 30 carbon atoms, and aryl groups of 6 to 30 carbon atoms with hetero atoms; and n is an integer from 4 to 20 , wherein the cucurbituril derivatives having the formula (1), where n=6 , R1=H, R2=H and X=O, and n=5 , R1=CH3, R2=H and X=O, are excluded. The cucurbituril derivatives are easily prepared as a mixture by one of the three new methods, and each cucurbituril derivative can be separated from the mixture by fractional crystallization. The cucurbituril derivatives having the formula (1) or their mixtures are very useful in removing dyes and heavy metal ions dissolved in water or waste water.

摘要翻译： 披露了葫芦素衍生物的用途。 葫芦巴衍生物具有式（1）其中X是O，S或NH; R 1和R 2独立地选自氢，碳原子数1〜30的烷基，碳原子数1〜30的烯基，炔基， 1至30个碳原子，1至30个碳原子的烷硫基，1至30个碳原子的烷基羧基，1至30个碳原子的羟基烷基，1至30个碳原子的烷基甲硅烷基，1至30个碳原子的烷氧基 1〜30个碳原子的卤代烷基，硝基，1〜30个碳原子的烷基胺基，1〜30个碳原子的氨基烷基，5〜30个碳原子的未取代环烷基，4-30个碳原子的环烷基 具有杂原子的碳原子，6至30个碳原子的未取代芳基和6至30个碳原子的芳基与杂原子; 并且n为4至20的整数，其中具有式（1）的葫芦脲衍生物，其中n = 6，R 1 = H，R 2 H = H和 X = O，n = 5，R 1 = CH 3，R 2 = H，X = O。 通过三种新方法之一容易地制备葫芦巴脲衍生物作为混合物，并且可以通过分级结晶从混合物中分离出每种葫芦巴脲衍生物。 具有式（1）的葫芦巴衍生物或其混合物非常适用于去除溶于水或废水中的染料和重金属离子。

公开(公告)号：US09101669B2

公开(公告)日：2015-08-11

申请号：US13362205

申请日：2012-01-31

申请人： Sei Kwang Hahn ,  Kimoon Kim ,  Hyuntae Jung ,  Jeong-A Yang ,  Kyeng Min Park

发明人： Sei Kwang Hahn ,  Kimoon Kim ,  Hyuntae Jung ,  Jeong-A Yang ,  Kyeng Min Park

IPC分类号： A61K31/74 ,  A61K47/38 ,  A61K47/36 ,  A61K31/337 ,  A61K31/513 ,  A61K31/65 ,  A61K31/704 ,  A61K31/713 ,  A61K33/24 ,  A61K39/39 ,  A61K49/00 ,  C08B37/08 ,  C08L5/08 ,  A61K45/06 ,  A61K47/24 ,  A61K9/06 ,  A61K47/34 ,  A61K31/436 ,  A61K31/138 ,  A61K31/4745 ,  A61K31/555 ,  A61K31/7068 ,  A61K47/48 ,  A61K8/11 ,  B82Y5/00

CPC分类号： A61K47/38 ,  A61K9/06 ,  A61K31/138 ,  A61K31/337 ,  A61K31/436 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/555 ,  A61K31/65 ,  A61K31/704 ,  A61K31/7068 ,  A61K31/713 ,  A61K33/24 ,  A61K39/39 ,  A61K45/06 ,  A61K47/24 ,  A61K47/34 ,  A61K47/36 ,  A61K47/61 ,  A61K47/6903 ,  A61K49/0043 ,  A61K49/0054 ,  B82Y5/00 ,  C08B37/0072 ,  C08L5/08

摘要： Provided are a self-assembled conjugate of a host molecule containing compound and a guest molecule containing compound, a delivery composition of a bioactive material comprising the self-assembled conjugate and a bioactive material to be delivered, and a composition for tissue engineering containing the self-assembled conjugate and a cell.

摘要翻译： 提供含有宿主分子的化合物和含客体分子的化合物的自组装缀合物，包含自组装缀合物的生物活性材料的递送组合物和待递送的生物活性物质，以及包含自身的组织工程组合物 - 组合的缀合物和细胞。

公开(公告)号：US07745620B2

公开(公告)日：2010-06-29

申请号：US10598861

申请日：2004-03-13

申请人： Kimoon Kim ,  Jae Wook Lee ,  Dong Hyun Oh ,  Jeongmin Ju

发明人： Kimoon Kim ,  Jae Wook Lee ,  Dong Hyun Oh ,  Jeongmin Ju

IPC分类号： C07D257/10 ,  C07D235/02

CPC分类号： C07D487/22

摘要： Provided are a disubstituted cucurbituril that can be easily substituted by a substituent according to a desired usage and a method for preparing the same. The disubstituted cucurbituril has two end functional groups that can covalently bind with a solid substrate or a biochemically useful compound to obtain a cucurbituril-bonded substrate, which enables application of the disubstituted cucurbituril as column packing materials for chromatography, additives to gas separation membranes, catalysts for various chemical reactions, chemical sensors, or biological sensors.

摘要翻译： 本发明提供可以根据期望的用途容易地被取代基取代的二取代的葫芦巴脲及其制备方法。 二取代的葫芦巴具有两个可与固体底物或生物化学有用的化合物共价结合的末端官能团，以获得葫芦素键合的底物，其可以应用二取代的葫芦素作为色谱柱的填充材料，气体分离膜的添加剂，催化剂 用于各种化学反应，化学传感器或生物传感器。