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公开(公告)号：US07714138B2
公开(公告)日：2010-05-11
申请号：US12253491
申请日：2008-10-17
申请人： Robert M. Borzilleri , Lyndon A. M. Cornelius , Robert J. Schmidt , Gretchen M. Schroeder , Kyoung S. Kim
发明人： Robert M. Borzilleri , Lyndon A. M. Cornelius , Robert J. Schmidt , Gretchen M. Schroeder , Kyoung S. Kim
IPC分类号： C07D211/72 , A61K31/44
CPC分类号： C07D213/82 , C07D213/68 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/89 , C07D239/34 , C07D239/42 , C07D239/47 , C07D401/06 , C07D401/12 , C07D401/14 , C07D417/12
摘要： The present invention is directed to compounds having the formula and methods for using them for the treatment of cancer.
摘要翻译： 本发明涉及具有下式的化合物及其用于治疗癌症的方法。
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公开(公告)号：US07173031B2
公开(公告)日：2007-02-06
申请号：US11167049
申请日：2005-06-24
申请人： Robert M. Borzilleri , Zhong Chen , John T. Hunt , Tram Huynh , Michael A. Poss , Gretchen M. Schroeder , Wayne Vaccaro , Tai W. Wong , Xiao-Tao Chen , Kyoung S. Kim
发明人： Robert M. Borzilleri , Zhong Chen , John T. Hunt , Tram Huynh , Michael A. Poss , Gretchen M. Schroeder , Wayne Vaccaro , Tai W. Wong , Xiao-Tao Chen , Kyoung S. Kim
IPC分类号： C07D487/04 , C07D401/02 , A61K31/53 , A61P35/00
CPC分类号： C07D471/04 , C07D473/00 , C07D473/30 , C07D487/04 , C07D495/04
摘要： In general, the instant invention comprises compounds of Formulas I and II including pharmaceutically acceptable salts thereof. The compounds of the invention are useful as protein kinase inhibitors and therefore are useful for treating cancer and other protein kinase mediated diseases.
摘要翻译： 通常，本发明包括式I和II的化合物，包括其药学上可接受的盐。 本发明的化合物可用作蛋白激酶抑制剂，因此可用于治疗癌症和其它蛋白激酶介导的疾病。
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公开(公告)号：US07989477B2
公开(公告)日：2011-08-02
申请号：US12727534
申请日：2010-03-19
申请人： Robert M. Borzilleri , Lyndon A. M. Cornelius , Robert J. Schmidt , Gretchen M. Schroeder , Kyoung S. Kim
发明人： Robert M. Borzilleri , Lyndon A. M. Cornelius , Robert J. Schmidt , Gretchen M. Schroeder , Kyoung S. Kim
IPC分类号： A61K31/44
CPC分类号： C07D213/82 , C07D213/68 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/89 , C07D239/34 , C07D239/42 , C07D239/47 , C07D401/06 , C07D401/12 , C07D401/14 , C07D417/12
摘要： The present invention is directed to compounds having the formula and methods for using them for the treatment of cancer.
摘要翻译： 本发明涉及具有下式的化合物及其用于治疗癌症的方法。
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公开(公告)号：US20090054436A1
公开(公告)日：2009-02-26
申请号：US12253491
申请日：2008-10-17
申请人： Robert M. Borzilleri , Lyndon A.M. Cornelius , Robert J. Schmidt , Gretchen M. Schroeder , Kyoung S. Kim
发明人： Robert M. Borzilleri , Lyndon A.M. Cornelius , Robert J. Schmidt , Gretchen M. Schroeder , Kyoung S. Kim
IPC分类号： A61K31/4412 , C07D211/74 , C07D239/34 , A61K31/513 , A61P43/00 , A61K31/5377 , C07D239/47 , C07D413/12
CPC分类号： C07D213/82 , C07D213/68 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/89 , C07D239/34 , C07D239/42 , C07D239/47 , C07D401/06 , C07D401/12 , C07D401/14 , C07D417/12
摘要： The present invention is directed to compounds having the formula and methods for using them for the treatment of cancer.
摘要翻译： 本发明涉及具有下式的化合物及其用于治疗癌症的方法。
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公开(公告)号：US07470693B2
公开(公告)日：2008-12-30
申请号：US11406795
申请日：2006-04-19
IPC分类号： C07D471/02 , A61K31/519
CPC分类号： C07D213/81 , C07D213/73 , C07D401/04
摘要： The invention is directed to compounds having the following Formula I: and methods of using them for the treatment of proliferative diseases.
摘要翻译： 本发明涉及具有下列通式I的化合物及其用于治疗增殖性疾病的方法。
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公开(公告)号：US06291684B1
公开(公告)日：2001-09-18
申请号：US09528230
申请日：2000-03-17
IPC分类号： C07D20326
CPC分类号： C07D491/04
摘要： The present invention relates to a stereospecific process to produce aziridinyl epothilones from oxiranyl epothilones and the intermediates derived therein.
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公开(公告)号：USRE41893E1
公开(公告)日：2010-10-26
申请号：US12539498
申请日：2009-08-11
IPC分类号： C07D417/06 , C07D277/26 , C07D277/20 , A61K31/425 , A61P35/00
CPC分类号： C07D491/044 , C07D417/06 , C07D491/04 , C07D493/04
摘要： The present invention relates to epothilone derivatives, having the following formula in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1-R7 are as defined herein, methods for the preparation of the derivatives and intermediates thereof.
摘要翻译： 本发明涉及具有下式的埃坡霉素衍生物，其中变量G，W，Q，X，Y，B1，B2，Z1，Z2和R1-R7如本文所定义，衍生物的制备方法 及其中间体。
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公开(公告)号：US07241755B2
公开(公告)日：2007-07-10
申请号：US11512623
申请日：2006-08-30
IPC分类号： C07D493/04 , C07D417/06 , C07D227/20 , A61K31/425 , A61P35/00
CPC分类号： C07D491/044 , C07D417/06 , C07D491/04 , C07D493/04
摘要： The present invention relates to compounds of the formula in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1–R7 are as defined herein, methods for the preparation of the derivatives and intermediates thereof.
摘要翻译： 本发明涉及下式的化合物，其中变量G，W，Q，X，Y，B 1，B 2，Z 1， Z 2，Z 2和R 1 -R 7如本文所定义，其衍生物的制备方法和中间体。
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公开(公告)号：US07125899B2
公开(公告)日：2006-10-24
申请号：US10405886
申请日：2003-04-03
IPC分类号： C07D493/04 , C07D417/06 , C07D227/20 , A61K31/425 , A61P35/00
CPC分类号： C07D491/044 , C07D417/06 , C07D491/04 , C07D493/04
摘要： The present invention relates to epothilone derivatives, having the following formula: in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1–R7 are defined herein, methods for preparation of the derivatives and intermediates thereof.
摘要翻译： 本发明涉及具有下式的埃坡霉素衍生物：其中变量G，W，Q，X，Y，B 1，B 2，Z，SUB > 1，Z 2和R 1-R 7是本文定义的衍生物及其中间体的制备方法 。
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公开(公告)号：USRE39356E1
公开(公告)日：2006-10-17
申请号：US11056606
申请日：2005-02-11
申请人： Wen Sen Li , John E. Thornton , Zhenrong Guo , Shankar Swaminathan , Robert M. Borzilleri , Soong-Hoon Kim , Denis Favreau
发明人： Wen Sen Li , John E. Thornton , Zhenrong Guo , Shankar Swaminathan , Robert M. Borzilleri , Soong-Hoon Kim , Denis Favreau
IPC分类号： C07D491/00 , C07D417/00
摘要： The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs.
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