公开(公告)号：US10458977B2

公开(公告)日：2019-10-29

申请号：US15310303

申请日：2015-05-15

Applicant: Laboratoires Expanscience

Inventor： Nadege Lachman ,  Philippe Msika ,  Joachim Fluhr

IPC: G01N33/50 ,  A61B5/00 ,  G06T7/00

Abstract: The present invention relates to a method for determining the relief of the skin surface of a subject, and hence the degree of maturation of the said skin surface. Methods for identifying active agents, raw materials and formulation are also provided.

公开(公告)号：US10444226B2

公开(公告)日：2019-10-15

申请号：US14915702

申请日：2014-09-03

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe Msika ,  Nadège Lachmann ,  Caroline Baudouin

IPC: G01N31/00 ,  G01N33/53 ,  G01N33/50 ,  G01N33/68

Abstract: A method for determining whether the skin surface of a subject is mature/immature in its organization/function, by taking a skin sample and determining the corneodesmosome distribution within the stratum corneum of the sample by an immunoelectron microscopy method.

公开(公告)号：US10092495B2

公开(公告)日：2018-10-09

申请号：US14766602

申请日：2014-02-11

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe Msika ,  Caroline Baudouin

IPC: A61K31/7024 ,  A61K8/60 ,  A61K31/22 ,  C07C69/02 ,  C07C69/52 ,  C07C69/533 ,  A61K31/232 ,  C07C69/587 ,  A61K31/23 ,  A61Q19/00 ,  A61Q19/08 ,  A61K45/06 ,  A61K31/7012 ,  A61K36/54 ,  A61K8/97 ,  A61Q5/02 ,  A61Q17/04 ,  A61Q19/10

Abstract: The invention concerns a use of C7 sugars and derivatives of formula (I), called avocado perseose, which have, inter alia, a protective activity to epidermal skin cells. These C7 sugars and derivatives are capable of maintaining the expression of markers of adult stem cells, in particular basal stem cells. Avocado perseose can also be used for preventing the deleterious effects of environmental damage. Avocado perseose has a beneficial effect on the conservation of the potential of epidermal stem cells and thus helps maintain skin homeostasis.

公开(公告)号：US20140357879A1

公开(公告)日：2014-12-04

申请号：US14368895

申请日：2012-12-26

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe Msika ,  Jacques Legrand

IPC: C11B1/06

CPC classification number: C11B1/06 ,  A23L19/00 ,  A23L33/105 ,  A23L33/115 ,  A61K36/54 ,  C11B1/04 ,  C11B1/08 ,  C11B1/10 ,  C11B1/102

Abstract: The present invention relates to the use of whole soft avocados for preparing avocado oil rich in unsaponifiables, said unsaponifiables containing aliphatic acetogenins and/or derivatives thereof. Advantageously, the oil has an acid value of less than or equal to 3 mg KOH/g. The invention further relates to a method for preparing avocado oil rich in unsaponifiables from whole soft avocados, said unsaponifiables containing aliphatic acetogenins and/or derivatives thereof. The invention further relates to avocado oil which is rich in unsaponifiables and which can be prepared by said method. The invention further relates to the use of the avocado oil for preparing an avocado oil concentrate enriched with unsaponifiables, or avocado unsaponifiables that are rich in aliphatic furans. Finally, the invention relates to avocado unsaponifiables which are rich in aliphatic furans or to an avocado oil concentrate which is enriched with unsaponifiables, and which can be prepared from said avocado oil, for the use thereof as a drug, advantageously for the prevention and/or treatment of disorders of the conjunctive tissue, such as arthrosis, joint conditions, such as rheumatism, or periodontal diseases, such as gingivitis or periodontitis.

Abstract translation: 本发明涉及用于制备富含不皂化物的鳄梨油的所述软的鳄梨油，所述不可皂化物含有脂族乙酰胆碱和/或其衍生物。 有利地，油的酸值小于或等于3mg KOH / g。 本发明还涉及一种制备富含不可皂化物的鳄梨油的方法，该方法包括脂肪族乙酰胆碱和/或其衍生物。 本发明还涉及富含不皂化物并且可以通过所述方法制备的鳄梨油。 本发明还涉及鳄梨油用于制备富含不可皂化物的鳄梨油浓缩物或富含脂肪族呋喃的鳄梨不皂化物的用途。 最后，本发明涉及富含脂肪族呋喃的鳄梨不可皂化物或富含不皂化物的鳄梨油浓缩物，并且其可由所述鳄梨油制备用于药物，有利地用于预防和/ 或治疗结膜组织疾病，如关节病，关节病，如风湿病，牙周病如牙龈炎或牙周炎。