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公开(公告)号：US10444225B2
公开(公告)日：2019-10-15
申请号：US14418645
申请日：2013-08-02
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Philippe Msika , Nadège Lachmann , Joachim Fluhr
IPC: G01N33/50
Abstract: The present invention relates to a method for determining the isotropy of the skin surface of a subject, and hence the degree of maturation of the said skin surface, by examining various parameters reflecting the cell organization. Methods for identifying active agents, raw materials and formulation are also provided.
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公开(公告)号：US10143648B2
公开(公告)日：2018-12-04
申请号：US15529694
申请日：2015-11-26
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Philippe Msika , Caroline Baudouin , Stéphanie Bredif
Abstract: The present invention relates to the use of a peptide and glycoside extract of Schizandra fruit as a cutaneous neurosensory agent, for improving the response of the cutaneous neurosensory system, in particular for: —improving cutaneous innervation in the basal state, —combatting age-related loss of cutaneous innervation in the basal state, advantageously for preventing loss of the cutaneous sensitivity and/or combatting thinning of the epidermis, and/or —improving cutaneous perception of the environment, more particularly for combatting burns, extreme cold and/or pain.
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公开(公告)号：US09616009B2
公开(公告)日：2017-04-11
申请号：US14514646
申请日：2014-10-15
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Caroline Baudouin , Philippe Msika
IPC: A61K8/60 , A61K8/97 , A61K9/48 , A61K31/70 , A61K31/7004 , A61K36/54 , A61K45/06 , A61Q3/00 , A61Q7/00 , A23L2/52 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A23L7/126 , A61Q5/00
CPC classification number: A61K8/60 , A23L2/52 , A23L7/126 , A23V2002/00 , A61K8/97 , A61K9/4858 , A61K31/70 , A61K31/7004 , A61K36/54 , A61K45/06 , A61K2800/5922 , A61K2800/92 , A61Q3/00 , A61Q5/00 , A61Q5/006 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q7/00 , A61K2300/00
Abstract: The present invention relates to a composition including at least one C7 sugar, or derivative from esterification of said sugar, and a pharmaceutically acceptable carrier for treating alopecia. The present invention also relates to a method for cosmetically treating hair and nails, said method being intended to stimulate the growth thereof and/or slow the loss thereof. According to said method, a cosmetic composition including at least one C7 sugar, or derivative from esterification of said sugar, is administered. The present invention finally relates to a method for cosmetic care of hair and/or eyelashes and/or nails.
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4.发明授权公开(公告)号：US09422504B2
公开(公告)日：2016-08-23
申请号：US14368895
申请日：2012-12-26
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Philippe Msika , Jacques Legrand
CPC classification number: C11B1/06 , A23L19/00 , A23L33/105 , A23L33/115 , A61K36/54 , C11B1/04 , C11B1/08 , C11B1/10 , C11B1/102
Abstract: The present invention relates to the use of whole soft avocados to obtain an avocado oil rich in unsaponifiable, said unsaponifiable containing aliphatic acetogenins and/or their derivatives. Advantageously, the oil has an acid value less than or equal to 3 mgKOH/g. The invention also relates to a process for obtaining an avocado oil rich in unsaponifiable from whole soft avocados. said unsaponifiable containing aliphatic acetogenins and/or their derivatives. The invention also relates to an avocado oil rich in unsaponifiable obtainable by this process. The invention also relates to the use of the avocado oil to prepare a concentrate of avocado oil enriched in unsaponifiable or an avocado unsaponifiable rich in aliphatic furans. Finally, the invention relates to an avocado unsaponifiable rich in aliphatic furans or a concentrate of avocado oil enriched in unsaponifiable, obtainable from said avocado oil, for its use as a drug, advantageously in the prevention and/or the treatment of connective tissue disorders such as arthrosis, articular pathologies such as rhumatisms, or parodontal disorders, such as gingivitis or parodontitis.
Abstract translation: 本发明涉及使用整个软的鳄梨来获得富含不皂化的所述不皂化的含脂肪酸乙偶姻和/或其衍生物的鳄梨油。 有利地，油的酸值小于或等于3mgKOH / g。 本发明还涉及一种从整个软鳄梨中获得不可皂化的鳄梨油的方法。 所述不可皂化的含脂肪族乙酰胆酸和/或其衍生物。 本发明还涉及一种富含不可皂化的鳄梨油，可通过该方法获得。 本发明还涉及鳄梨油用于制备富含不可皂化的鳄梨油的浓缩物或不可皂化的富含脂肪族呋喃的鳄梨油。 最后，本发明涉及不可皂化的富含脂肪呋喃的鳄梨或富含不皂化油的鳄梨油浓缩物，可从所述鳄梨油获得，用于药物，有利地用于预防和/或治疗结缔组织疾病，例如 作为关节病，关节病变如眩晕症或传染疾病，例如牙龈炎或牙菌斑。
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公开(公告)号：US10196607B2
公开(公告)日：2019-02-05
申请号：US15110826
申请日：2015-01-12
Applicant: Laboratoires Expanscience
Inventor： Stephanie Bredif , Caroline Baudouin , Philippe Msika , Marisa Meloni
Abstract: A skin model comprises keratinocytes capable of overexpressing filaggrin. A method for evaluating the in vitro activity of a formulation or of at least one active agent on the healing of nipple skin and/or on the reduction of nipple skin inflammation, by bringing said active agent or said formulation into contact with a skin model comprising keratinocytes overexpressing filaggrin and also comprising a lesion, and measuring the level of production of at least one biological marker chosen from lactate dehydrogenase (LDH), TNFα, filaggrin, TGFβ1 and β1 integrin.
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Patent Agency Ranking
6.发明申请EXTRACT OF PASSIONFLOWER SEEDS AND COSMETIC, PHARMACEUTICAL, DERMATOLOGICAL AND NUTRACEUTICAL COMPOSITIONS COMPRISING SAME 审中-公开SION草种子和化妆品，药物，皮肤和营养组合物的提取物公开(公告)号：US20160074312A1
公开(公告)日：2016-03-17
申请号：US14652449
申请日：2013-12-18
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Philippe Msika , Sophie Leclere-Bienfait , Sebastien Debrock , Stephanie Bredif , Sebastien Garnier
IPC: A61K8/97 , A61K8/60 , A61Q19/02 , A61Q19/08 , A61Q5/12 , A61Q19/00 , A61K36/185 , A61K45/06 , A61Q5/02 , A61K8/64 , A61Q17/04
CPC classification number: A61K8/97 , A61K8/60 , A61K8/645 , A61K36/185 , A61K45/06 , A61K2236/15 , A61K2236/19 , A61Q5/02 , A61Q5/12 , A61Q7/00 , A61Q17/00 , A61Q17/04 , A61Q19/005 , A61Q19/007 , A61Q19/02 , A61Q19/06 , A61Q19/08
Abstract: The invention relates to a composition comprising an extract of passionflower seeds, and preferentially Passiflora edulis seeds. The composition is advantageously cosmetic, pharmaceutical, dermatological or nutraceutical. The subject matter of the invention is also a process for extracting an extract of passionflower seeds and preferentially Passiflora edulis seeds, and also the extract which can be obtained by means of said process. The invention also relates to such a composition or such an extract for use in the prevention or treatment of disorders or pathological conditions of the skin, of the mucous membranes or of the skin appendages, for use in the prevention or treatment of vascular disorders, for use for combating oxidative stress, or else for use in the prevention or treatment of adipose tissue modifications. Finally, the invention relates to a cosmetic care process for the skin, the skin appendages or the mucous membranes, with a view to improving, the condition thereof or the appearance thereof, consisting in administering such a composition or such an extract.
Abstract translation: 本发明涉及包含西番莲花提取物，优选西番莲花种子的组合物。 该组合物有利地是化妆品，药物，皮肤病学或营养品。 本发明的主题也是提取西番莲子提取物和优选西番莲种子的方法，以及可以通过所述方法获得的提取物。 本发明还涉及用于预防或治疗皮肤，粘膜或皮肤附件的疾病或病理状况的用于预防或治疗血管疾病的组合物或这种提取物，用于 用于抵抗氧化应激，或用于预防或治疗脂肪组织修饰。 最后，本发明涉及一种美容护理方法，用于皮肤，皮肤附属物或粘膜，以改善其状况或其外观，包括施用这样的组合物或这种提取物。
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7.发明申请USE OF A COMPOSITION COMPRISING AVOCADO PERSEOSE IN THE PROTECTION OF EPIDERMAL STEM CELLS 审中-公开使用包含AVOCADO相关物质在保护皮肤干细胞中的组合物公开(公告)号：US20150374605A1
公开(公告)日：2015-12-31
申请号：US14766602
申请日：2014-02-11
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Philippe Msika , Caroline Baudouin
CPC classification number: A61K8/60 , A61K8/97 , A61K31/22 , A61K31/23 , A61K31/232 , A61K31/7012 , A61K31/7024 , A61K36/54 , A61K45/06 , A61Q5/02 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/005 , A61Q19/08 , A61Q19/10 , C07C69/02 , C07C69/52 , C07C69/533 , C07C69/587 , A61K2300/00
Abstract: The invention concerns a use of C7 sugars and derivatives of formula (I), called avocado perseose, which have, inter alia, a protective activity to epidermal skin cells. These C7 sugars and derivatives are capable of maintaining the expression of markers of adult stem cells, in particular basal stem cells. Avocado perseose can also be used for preventing the deleterious effects of environmental damage. Avocado perseose has a beneficial effect on the conservation of the potential of epidermal stem cells and thus helps maintain skin homeostasis.
Abstract translation: 本发明涉及C7糖和式（I）的衍生物，其被称为鳄梨坚果，其特别地对表皮皮肤细胞具有保护性活性。 这些C7糖和衍生物能够维持成体干细胞，特别是基础干细胞的标志物的表达。 鳄梨坚果也可用于防止环境破坏的有害影响。 鳄梨坚果对保护表皮干细胞的潜力有益，从而有助于维持皮肤稳态。
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公开(公告)号：US20150153328A1
公开(公告)日：2015-06-04
申请号：US14418645
申请日：2013-08-02
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Philippe Msika , Nadège Lachmann , Joachim Fluhr
IPC: G01N33/50
Abstract: The present invention relates to a method for determining the isotropy of the skin surface of a subject, and hence the degree of maturation of the said skin surface, by examining various parameters reflecting the cell organization. Methods for identifying active agents, raw materials and formulation are also provided.
Abstract translation: 本发明涉及通过检查反映细胞组织的各种参数来确定受试者的皮肤表面的各向同性，从而确定所述皮肤表面的成熟度的方法。 还提供了确定活性剂，原料和制剂的方法。
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公开(公告)号：US10175230B2
公开(公告)日：2019-01-08
申请号：US14785212
申请日：2014-04-22
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Philippe Msika , Caroline Baudouin , Stephanie Bredif
Abstract: The invention relates to a method for evaluating the effectiveness of an active ingredient selected from C7 avocado sugars, also called avocado perseose, for preventing or treating a deficiency of the skin barrier, said method comprising the determination of the level of expression and/or activation of at least one biological marker, where said biological marker is selected from epidermal maturation markers, lipid barrier markers, hydric regulation markers and stratum granulosum regulation markers.
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公开(公告)号：US09952201B2
公开(公告)日：2018-04-24
申请号：US15023882
申请日：2014-09-24
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Caroline Baudouin , Stephanie Bredif , Philippe Msika
CPC classification number: G01N33/5023 , G01N33/5044 , G01N33/6881 , G01N2333/4721 , G01N2333/5421 , G01N2333/545 , G01N2333/96486
Abstract: The invention relates to in vitro methods for testing formulations or active ingredients for preventing the harmful effects of UV on children's skin, in particular children aged three or less. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the harmful effects of UV on the skin of children aged three or less, using a skin model specifically capable of reproducing the characteristics of the skin of children of this age.
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