Compositions comprising cationic amphiphiles and colipids for delivering therapeutic molecules
    22.
    发明授权
    Compositions comprising cationic amphiphiles and colipids for delivering therapeutic molecules 有权
    包含用于递送治疗分子的阳离子两亲物和辣椒的组合物

    公开(公告)号:US09080186B2

    公开(公告)日:2015-07-14

    申请号:US13320901

    申请日:2010-05-16

    摘要: This disclosure provides compositions consisting of solid mixture of cationic lipids and a polynucleotide, wherein the cationic lipid molecules form a water-insoluble ionic complex with the polynucleotide. What is also described is an anhydrous mixture of the cationic lipids and the polynucleotide solubilized in an organic or polar aprotic solvent. The anhydrous compositions are useful in preparing therapeutic formulations and in the diagnosis and treatment of diseases and conditions. The compositions are useful for delivery of agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.

    摘要翻译: 本公开提供了由阳离子脂质和多核苷酸的固体混合物组成的组合物,其中阳离子脂质分子与多核苷酸形成水不溶性离子络合物。 还描述了阳离子脂质和溶解在有机或极性非质子溶剂中的多核苷酸的无水混合物。 无水组合物可用于制备治疗剂型和疾病和病症的诊断和治疗。 所述组合物可用于将诸如核酸治疗剂的试剂递送至细胞,组织,器官和受试者。

    LIPOMACROCYCLES AND USES THEREOF
    23.
    发明申请
    LIPOMACROCYCLES AND USES THEREOF 有权
    LIPOMACROCYCLES及其用途

    公开(公告)号:US20130156851A1

    公开(公告)日:2013-06-20

    申请号:US13819147

    申请日:2011-08-26

    摘要: What is described are macrocyclic compounds formed by reaction of a cyclic compound, which contains an amine, with an epoxide. The macrocyclic compound has the following structure: When substituents R and R′ that are hydrophobic substituents, the macrocyclic compound functions as a lipid and is compatible with lipid systems, including liposomes and lipid particles. When present in certain lipid systems, the macrocyclic compound enhances the ability of the lipid system to facilitate delivery of therapeutic molecules to target cells in a mammalian subject.

    摘要翻译: 所描述的是通过含有胺的环状化合物与环氧化物反应形成的大环化合物。 大环化合物具有以下结构:当作为疏水取代基的取代基R和R'时,大环化合物起脂质的作用,并且与脂质体系(包括脂质体和脂质)相容。 当存在于某些脂质体系中时,大环化合物增强了脂质系统促进治疗分子向哺乳动物受试者中的靶细胞递送的能力。

    Method for opening tight junctions
    26.
    发明授权
    Method for opening tight junctions 失效
    打开紧密连接处的方法

    公开(公告)号:US07696343B2

    公开(公告)日:2010-04-13

    申请号:US11624630

    申请日:2007-01-18

    IPC分类号: C07H21/04 C07H21/02

    摘要: The use of antagonists to JAM-1 Claudin-4 and occludin to open tight junctions. The antagonists include, by way of example antibodies and antibody fragments that bind to the proteins and small interfering nucleic acids that downregulate the mRNA encoding the proteins.

    摘要翻译: 使用拮抗剂对JAM-1紧密连接蛋白-4和闭合蛋白打开紧密连接。 拮抗剂包括例如结合蛋白的抗体和抗体片段以及下调编码蛋白质的mRNA的小干扰核酸。

    Tight Junction Modulating Peptides for Enhanced Mucosal Delivery of Therapeutic Compounds
    27.
    发明申请
    Tight Junction Modulating Peptides for Enhanced Mucosal Delivery of Therapeutic Compounds 审中-公开
    紧密连接调节肽用于增强粘膜递送治疗化合物

    公开(公告)号:US20090274658A1

    公开(公告)日:2009-11-05

    申请号:US12480519

    申请日:2009-06-08

    摘要: Compositions and methods are provided that include a biologically active agent and a permeabilizing agent effective to enhance mucosal delivery of the biologically active agent in a mammalian subject, in which the permeabilizing peptide is a tight junction modulating peptide (TJMP), a TJMP analogue, a conjugate of a TJMP, a conjugate of a TJMP analogue, or complexes thereof. The permeabilizing agent reversibly enhances mucosal epithelial paracellular transport, typically by modulating epithelial junctional structure and/or physiology at a mucosal epithelial surface in the subject.

    摘要翻译: 提供的组合物和方法包括有效增强哺乳动物受试者中生物活性剂的粘膜递送的生物活性剂和渗透剂,其中透化肽是紧密连接调节肽(TJMP),TJMP类似物, TJMP的缀合物,TJMP类似物的缀合物或其复合物。 透化剂通常通过调节受试者的粘膜上皮表面的上皮连接结构和/或生理学来可逆地增强粘膜上皮细胞旁转运。

    TIGHT JUNCTION MODULATING PEPTIDES FOR ENHANCED MUCOSAL DELIVERY OF THERAPEUTIC COMPOUNDS
    29.
    发明申请
    TIGHT JUNCTION MODULATING PEPTIDES FOR ENHANCED MUCOSAL DELIVERY OF THERAPEUTIC COMPOUNDS 审中-公开
    用于增强治疗化合物的粘膜递送的轻度结节调节肽

    公开(公告)号:US20070154449A1

    公开(公告)日:2007-07-05

    申请号:US11611289

    申请日:2006-12-15

    摘要: Compositions and methods are provided that include a biologically active agent and a permeabilizing agent effective to enhance mucosal delivery of the biologically active agent in a mammalian subject, in which the permeabilizing peptide is a tight junction modulating peptide (TJMP), a TJMP analogue, a conjugate of a TJMP, a conjugate of a TJMP analogue, or complexes thereof. The permeabilizing agent reversibly enhances mucosal epithelial paracellular transport, typically by modulating epithelial junctional structure and/or physiology at a mucosal epithelial surface in the subject.

    摘要翻译: 提供的组合物和方法包括有效增强哺乳动物受试者中生物活性剂的粘膜递送的生物活性剂和渗透剂,其中透化肽是紧密连接调节肽(TJMP),TJMP类似物, TJMP的缀合物,TJMP类似物的缀合物或其复合物。 透化剂通常通过调节受试者的粘膜上皮表面的上皮连接结构和/或生理学来可逆地增强粘膜上皮细胞旁转运。

    Nanoparticles for delivery of nucleic acids and stable double-stranded RNA
    30.
    发明申请
    Nanoparticles for delivery of nucleic acids and stable double-stranded RNA 审中-公开
    用于递送核酸和稳定双链RNA的纳米颗粒

    公开(公告)号:US20050136437A1

    公开(公告)日:2005-06-23

    申请号:US10925314

    申请日:2004-08-24

    摘要: Nanoparticles of double-stranded nucleic acid complexed about a complexing agent such as the melamine derivatives of formulae I and II, preferably forming a trimeric nucleic acid complex. In alternative embodiments, polyarginine or a polymer of Gln and Asn further complexed with the double-stranded nucleic acid complex. In a preferred embodiment, the ds nucleic acid is a double stranded RNA having 15 to 30 base pairs suitable for RNA interference. In another aspect of the invention, a ds RNA is produced in which all of the uridines are changed to 5-methyluridine. Preferably, the resultant ds RNAs have 15 to about 30 base pairs and are suitable for RNA interference.

    摘要翻译: 双链核酸的纳米颗粒与络合剂例如式I和II的三聚氰胺衍生物络合,优选形成三聚体核酸复合物。 在替代实施方案中,聚精氨酸或Gln和Asn的聚合物与双链核酸复合物进一步复合。 在优选的实施方案中,ds核酸是具有适合于RNA干扰的15至30个碱基对的双链RNA。 在本发明的另一方面,产生ds RNA,其中所有的尿苷都被改变成5-甲基尿苷。 优选地,所得ds RNA具有15至约30个碱基对并且适合于RNA干扰。