公开(公告)号：US20120091253A1

公开(公告)日：2012-04-19

申请号：US12198146

申请日：2008-08-26

Applicant: William N. Patterson ,  James H. Dupont ,  Richard D. Loehr ,  Henri Y. Kim ,  Garrett L. Hall ,  James M. Cook

Inventor： William N. Patterson ,  James H. Dupont ,  Richard D. Loehr ,  Henri Y. Kim ,  Garrett L. Hall ,  James M. Cook

IPC: F42B15/01

CPC classification number: F41H11/02 ,  F41F3/073 ,  F42B10/661 ,  F42B15/01 ,  F42B15/10

Abstract: A method of defeating an incoming missile, such as a rocket propelled grenade, includes soft launching an interceptor missile, and then using pitch over motors of the interceptor missile to alter course of the missile to a desired interception direction. By launching at a relatively slow speed, such as a speed less than or equal to 40 m/sec (130 ft/sec), the interceptor missile may reach the desired interception direction within 250 milliseconds of launch. The interceptor missile may be able to cover substantially all interception directions over a hemisphere or greater extent around a launch location. For example, the interceptor missile may be launched vertically from a ground vehicle, and be capable of altering course to any above-ground trajectory within 250 milliseconds.

Abstract translation: 一种击败诸如火箭推进手榴弹的进入导弹的方法包括软启动拦截导弹，然后使用拦截导弹发动机的俯仰角来将导弹的过程改变到所需的拦截方向。 通过以相对较慢的速度（例如小于或等于40米/秒（130英尺/秒）的速度）发射，拦截导弹可以在发射的250毫秒内达到所需的拦截方向。 拦截导弹可以能够围绕发射位置覆盖半球或更大程度上的所有拦截方向。 例如，拦截导弹可以从地面车辆垂直发射，并且能够在250毫秒内改变任何地面上的轨迹。

公开(公告)号：US20100327106A1

公开(公告)日：2010-12-30

申请号：US12877789

申请日：2010-09-08

Applicant: Robert S. Brinkerhoff ,  Michael J. Mahnken ,  Richard D. Loehr ,  James M. Cook

Inventor： Robert S. Brinkerhoff ,  Michael J. Mahnken ,  Richard D. Loehr ,  James M. Cook

IPC: F42B15/01 ,  B64G1/26

CPC classification number: F42B10/661 ,  G05D1/0883

Abstract: A reliable and inexpensive attitude control system uses a plurality of pitch-over thrusters to perform rapid and precise attitude maneuvers for a flight vehicle. The pitch-over thrusters create rotational moments that directly pitch and yaw the flight vehicle. The use of very simple thrusters and control techniques provides for a reliable and cost effective solution. The ability to perform overlapping pitch and yaw maneuvers with single-shot fixed-impulse thrusters provides for high-speed maneuverability.

Abstract translation: 可靠和廉价的姿态控制系统使用多个俯仰推进器来为飞行器执行快速和精确的姿态操纵。 俯仰推进器产生直接俯仰和偏航飞行器的旋转力矩。 使用非常简单的推进器和控制技术提供了可靠且具有成本效益的解决方案。 使用单次固定脉冲推进器执行重叠俯仰和偏航操作的能力提供高速机动性。

公开(公告)号：US20100048587A1

公开(公告)日：2010-02-25

申请号：US12425063

申请日：2009-04-16

Applicant: James M. Cook ,  David A. Baker ,  Wenyuan Yin ,  Edward Merle Johnson, II

Inventor： James M. Cook ,  David A. Baker ,  Wenyuan Yin ,  Edward Merle Johnson, II

IPC: A61K31/496 ,  C07C229/02 ,  A61K31/195 ,  C07D271/06 ,  A61K31/4245 ,  C07D413/02 ,  A61P25/18 ,  A61P25/30

CPC classification number: C07D271/06 ,  C07D413/12 ,  C07K5/0606

Abstract: The present invention provides cysteine and cystine bioisosteres for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing such bioisosteres and methods of using the bioisosteres for treatment of schizophrenia and drug addiction.

Abstract translation: 本发明提供了用于治疗精神分裂症和药物成瘾的半胱氨酸和胱氨酸生物电子等排体。 本发明还包括含有这种生物电子等排体的药物组合物和使用生物电子等离子体治疗精神分裂症和药物成瘾的方法。

公开(公告)号：US20100004226A1

公开(公告)日：2010-01-07

申请号：US12537399

申请日：2009-08-07

Applicant: James M. Cook ,  Hao Zhou ,  Shengming Huang ,  P.V.V.S. Sarma ,  Chunchun Zhang

Inventor： James M. Cook ,  Hao Zhou ,  Shengming Huang ,  P.V.V.S. Sarma ,  Chunchun Zhang

IPC: A61K31/5513 ,  C07D243/14 ,  C07D487/04 ,  C07D487/16 ,  A61P25/22 ,  A61K31/5517 ,  A61P25/32 ,  A61P25/00

CPC classification number: C07D243/24 ,  C07D243/16 ,  C07D471/06 ,  C07D487/04 ,  C07D487/06

Abstract: The present invention provides compositions and methods of using stereospecific benzodiazepine derivatives, their salts and prodrugs for the treatment of anxiolytic or convulsant disorders having the side effects of reduced alcohol craving in human alcoholics and a concomitant reduced sedative, hypnotic, muscle relaxant and ataxic side-effects. The invention further provides pharmaceutical compositions for treatment of anxiolytic and convulsant disorders in subjects in need thereof, comprising a compound, prodrug or a salt having a chemical structure represented by any one of Formula I-IV, VI-XI, XV-XVIII and XX-XXI and a pharmaceutically-acceptable carrier.

Abstract translation: 本发明提供了使用立体定向苯并二氮杂衍生物，其盐和前药用于治疗在人类酒精中具有降低酒精渴求的副作用的抗焦虑或惊厥疾病的组合物和方法，以及伴随的降低镇静剂，催眠药，肌肉松弛剂和共济失调副作用的组合物和方法， 效果。 本发明还提供用于治疗有需要的受试者的抗焦虑和惊厥疾病的药物组合物，其包含具有由式I-IV，VI-XI，XV-XVIII和XX中任一项所示的化学结构的化合物，前药或盐 -XXI和药学上可接受的载体。

公开(公告)号：US07595395B2

公开(公告)日：2009-09-29

申请号：US11383624

申请日：2006-05-16

Applicant: James M. Cook ,  Dongmei Han ,  Terry Clayton

Inventor： James M. Cook ,  Dongmei Han ,  Terry Clayton

IPC: C07D487/04

CPC classification number: C07D487/04 ,  C07D487/14 ,  C07D519/00

Abstract: The present invention provides molecules and methods for the prevention and/or treatment of memory deficit related conditions and/or enhancement of cognizance. In a preferred embodiment, the invention includes compounds, salts and prodrugs thereof for the prevention and/or treatment of these conditions.

Abstract translation: 本发明提供了用于预防和/或治疗记忆缺陷相关病症和/或增强认知的分子和方法。 在优选的实施方案中，本发明包括用于预防和/或治疗这些病症的化合物，其盐和前药。

公开(公告)号：US08962692B2

公开(公告)日：2015-02-24

申请号：US13465383

申请日：2012-05-07

Applicant: James M. Cook ,  David A. Baker ,  Wenyuan Yin ,  Edward Merle Johnson, II

Inventor： James M. Cook ,  David A. Baker ,  Wenyuan Yin ,  Edward Merle Johnson, II

IPC: A61K31/095 ,  A61K31/105 ,  C07C323/03 ,  C07C323/64 ,  C07C327/34 ,  C07C323/60 ,  C07D241/08 ,  C07D487/04 ,  C07K5/062

CPC classification number: C07D241/08 ,  A61K9/0053 ,  C07C323/60 ,  C07C327/34 ,  C07D211/86 ,  C07D487/04 ,  C07K5/0606

Abstract: The present invention discloses cysteine prodrugs having the general formula: cystine dimers of the cysteine prodrugs having the general formula: protected cysteine analogs having the general formula: and dimers of the protected cysteine analogs having the general formula: The invention further encompasses pharmaceutical compositions containing the disclosed prodrugs, dimers, and analogs, and methods of using such compounds for treatment of schizophrenia and drug addiction.

Abstract translation: 本发明公开了具有以下通式的半胱氨酸前药：具有以下通式的半胱氨酸前药的胱氨酸二聚体：具有以下通式的保护半胱氨酸类似物：具有以下通式的受保护的半胱氨酸类似物的二聚体：本发明还包括含有 公开的前药，二聚体和类似物，以及使用这些化合物治疗精神分裂症和药物成瘾的方法。

公开(公告)号：US08435997B2

公开(公告)日：2013-05-07

申请号：US12897353

申请日：2010-10-04

Applicant: James M. Cook ,  Edward Merle Johnson, II ,  David A. Baker ,  Wenyuan Yin

Inventor： James M. Cook ,  Edward Merle Johnson, II ,  David A. Baker ,  Wenyuan Yin

IPC: A61K31/497

CPC classification number: C07D241/08

Abstract: The present invention provides cysteine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction.

Abstract translation: 本发明提供了用于治疗精神分裂症和药物成瘾的半胱氨酸前药。 本发明还包括含有药物组合物的药物组合物和使用前药和组合物治疗精神分裂症和药物成瘾的方法。

公开(公告)号：US08268854B2

公开(公告)日：2012-09-18

申请号：US12471019

申请日：2009-05-22

Applicant: James M. Cook ,  Michael L. Van Linn ,  Wenyuan Yin

Inventor： James M. Cook ,  Michael L. Van Linn ,  Wenyuan Yin

IPC: C07D471/12 ,  A61K31/437

CPC classification number: C07D471/04

Abstract: Provided are compounds having the general structure according to Formula (I): Further provided are pharmaceutical compositions comprising these compounds. The invention still further provides methods of treating alcoholism, methods of reducing alcohol intake, methods of treating anhedonia, and methods of treating anxiety using theses compounds or the compositions containing them.

Abstract translation: 提供具有根据式（I）的一般结构的化合物：还提供包含这些化合物的药物组合物。 本发明还提供了使用这些化合物或含有它们的组合物治疗酒精中毒的方法，降低酒精摄取的方法，治疗焦虑的治疗方法和治疗焦虑症的方法。

公开(公告)号：US08173809B2

公开(公告)日：2012-05-08

申请号：US12367867

申请日：2009-02-09

Applicant: James M. Cook ,  David A. Baker ,  Wenyuan Yin ,  Edward Merle Johnson, II

Inventor： James M. Cook ,  David A. Baker ,  Wenyuan Yin ,  Edward Merle Johnson, II

IPC: C07D295/00

CPC classification number: C07D241/08 ,  A61K9/0053 ,  C07C323/60 ,  C07C327/34 ,  C07D211/86 ,  C07D487/04 ,  C07K5/0606

Abstract: The present invention provides cysteine and cystine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction. Exemplary prodrugs include the cysteine compound having the formula as well as cystine dimers thereof.

Abstract translation: 本发明提供了用于治疗精神分裂症和药物成瘾的半胱氨酸和胱氨酸前药。 本发明还包括含有药物组合物的药物组合物和使用前药和组合物治疗精神分裂症和药物成瘾的方法。 示例性的前药包括具有下式的半胱氨酸化合物及其胱氨酸二聚体。

公开(公告)号：US20100130481A1

公开(公告)日：2010-05-27

申请号：US12684845

申请日：2010-01-08

Applicant: James M. Cook ,  Qi Huang ,  Xiaohui He ,  Xioeyan Li ,  Jianming Yu ,  Dongmel Han

Inventor： James M. Cook ,  Qi Huang ,  Xiaohui He ,  Xioeyan Li ,  Jianming Yu ,  Dongmel Han

IPC: A61K31/551 ,  A61P25/22

CPC classification number: C07D471/04 ,  C07D243/12 ,  C07D243/20 ,  C07D243/24 ,  C07D487/04 ,  C07D487/06 ,  C07D495/04 ,  C07D495/14 ,  C07D498/04 ,  C07D519/00

Abstract: Methods of using orally active benzodiazepine derivatives and their salts are disclosed. These compounds and their salts have anticonvulsant and anxiolytic activity with reduced sedative, hypnotic, muscle relaxant, or ataxic effects.

Abstract translation: 公开了使用口服活性苯并二氮杂衍生物及其盐的方法。 这些化合物及其盐具有降低镇静，催眠，肌肉松弛剂或共济失调作用的抗惊厥和抗焦虑活性。