公开(公告)号：US20120308108A1

公开(公告)日：2012-12-06

申请号：US13488280

申请日：2012-06-04

申请人： Matthew J. Everett ,  Scott A. Meyer ,  Paul F. Stetson ,  Yan Zhou

发明人： Matthew J. Everett ,  Scott A. Meyer ,  Paul F. Stetson ,  Yan Zhou

IPC分类号： G06K9/78

CPC分类号： A61B5/0066 ,  G06T7/0014 ,  G06T19/00 ,  G06T2200/24 ,  G06T2207/10101 ,  G06T2207/30041 ,  G06T2210/41

摘要： The present invention discloses a method for generating elevation maps or images of a tissue layer/boundary with respect to a fitted reference surface, comprising the steps of finding and segmenting a desired tissue layer/boundary; fitting a smooth reference surface to the segmented tissue layer/boundary; calculating elevations of the same or other tissue layer/boundary relative to the fitted reference surface; and generating maps of elevation relative to the fitted surface. The elevation can be displayed in various ways including three-dimensional surface renderings, topographical contour maps, contour maps, en-face color maps, and en-face grayscale maps. The elevation can also be combined and simultaneously displayed with another tissue layer/boundary dependent set of image data to provide additional information for diagnostics.

摘要翻译： 本发明公开了一种用于产生相对于拟合的参考表面的组织层/边界的仰角图或图像的方法，包括以下步骤：发现和分割所需的组织层/边界; 将平滑的参考表面拟合到分段的组织层/边界; 计算相对于拟合参考表面的相同或其它组织层/边界的高度; 并产生相对于拟合表面的高程图。 高程可以以各种方式显示，包括三维表面效果图，地形轮廓图，轮廓图，面孔颜色图和面对灰度图。 也可以将高程组合并同时显示另一个组织层/边界依赖的图像数据集，以提供用于诊断的附加信息。

公开(公告)号：US20120045101A1

公开(公告)日：2012-02-23

申请号：US13283445

申请日：2011-10-27

申请人： Matthew J. Everett ,  Scott A. Meyer ,  Paul F. Stetson ,  Yan Zhou

发明人： Matthew J. Everett ,  Scott A. Meyer ,  Paul F. Stetson ,  Yan Zhou

IPC分类号： G06K9/00

CPC分类号： A61B5/0066 ,  G06T7/0014 ,  G06T19/00 ,  G06T2200/24 ,  G06T2207/10101 ,  G06T2207/30041 ,  G06T2210/41

摘要： The present invention discloses a method for generating elevation maps or images of a tissue layer/boundary with respect to a fitted reference surface, comprising the steps of finding and segmenting a desired tissue layer/boundary; fitting a smooth reference surface to the segmented tissue layer/boundary; calculating elevations of the same or other tissue layer/boundary relative to the fitted reference surface; and generating maps of elevation relative to the fitted surface. The elevation can be displayed in various ways including three-dimensional surface renderings, topographical contour maps, contour maps, en-face color maps, and en-face grayscale maps. The elevation can also be combined and simultaneously displayed with another tissue layer/boundary dependent set of image data to provide additional information for diagnostics.

公开(公告)号：US20110043757A1

公开(公告)日：2011-02-24

申请号：US12861672

申请日：2010-08-23

申请人： Matthew J. Everett ,  Claus Flachenecker ,  Martin Hacker ,  Scott A. Meyer ,  Keith E. O'Hara ,  RicK A. Williams

发明人： Matthew J. Everett ,  Claus Flachenecker ,  Martin Hacker ,  Scott A. Meyer ,  Keith E. O'Hara ,  RicK A. Williams

IPC分类号： A61B3/15 ,  A61B3/12

CPC分类号： A61B3/102 ,  A61B3/113

摘要： A line scan imager is used to determine the motion of a subject. Each line of image data from the line scan imager is compared with a reference image. The location of a matching line in the reference image reveals the displacement of the subject. The current subject displacement can be determined based on each line of image data. The resulting displacement information can be used to correctly place other optical beams on the subject. The method can be applied to tracking the human eye to facilitate measurement, imaging, or treatment with a beam of optical radiation.

摘要翻译： 行扫描成像器用于确定被摄体的运动。 将来自行扫描成像器的每行图像数据与参考图像进行比较。 参考图像中匹配线的位置显示了被摄体的位移。 可以基于每行图像数据来确定当前被摄体位移。 所得到的位移信息可用于将其他光束正确地放置在被摄体上。 该方法可以应用于跟踪人眼以便于用光束辐射进行测量，成像或处理。

公开(公告)号：US07668342B2

公开(公告)日：2010-02-23

申请号：US11223549

申请日：2005-09-09

申请人： Matthew J. Everett ,  Scott A. Meyer ,  Paul F. Stetson ,  Yan Zhou

发明人： Matthew J. Everett ,  Scott A. Meyer ,  Paul F. Stetson ,  Yan Zhou

IPC分类号： G06K9/00 ,  A61B5/103 ,  G01B9/02

CPC分类号： A61B5/0066 ,  G06T7/0014 ,  G06T19/00 ,  G06T2200/24 ,  G06T2207/10101 ,  G06T2207/30041 ,  G06T2210/41

摘要： The present invention discloses a method for generating elevation maps or images of a tissue layer/boundary with respect to a fitted reference surface, comprising the steps of finding and segmenting a desired tissue layer/boundary; fitting a smooth reference surface to the segmented tissue layer/boundary; calculating elevations of the same or other tissue layer/boundary relative to the fitted reference surface; and generating maps of elevation relative to the fitted surface. The elevation can be displayed in various ways including three-dimensional surface renderings, topographical contour maps, contour maps, en-face color maps, and en-face grayscale maps. The elevation can also be combined and simultaneously displayed with another tissue layer/boundary dependent set of image data to provide additional information for diagnostics.

摘要翻译： 本发明公开了一种用于产生相对于拟合的参考表面的组织层/边界的仰角图或图像的方法，包括以下步骤：找到并分割所需的组织层/边界; 将平滑的参考表面拟合到分段的组织层/边界; 计算相对于拟合参考表面的相同或其它组织层/边界的高度; 并产生相对于拟合表面的高程图。 高程可以以各种方式显示，包括三维表面效果图，地形轮廓图，轮廓图，面孔颜色图和面对灰度图。 也可以将高程组合并同时显示另一个组织层/边界依赖的图像数据集，以提供用于诊断的附加信息。

公开(公告)号：US07508525B2

公开(公告)日：2009-03-24

申请号：US12150375

申请日：2008-04-28

申请人： Yan Zhou ,  Matthew J. Everett ,  Martin Hacker

发明人： Yan Zhou ,  Matthew J. Everett ,  Martin Hacker

IPC分类号： G01B9/02 ,  G01B11/02

CPC分类号： G01B9/02091 ,  G01B2290/40

摘要： An interferometer configured for use in optical coherence domain (OCT) reflectometry systems is disclosed. In the preferred embodiments, efficient routing of light and a balanced detection arrangement provide a high signal to noise ratio. In one set of embodiments, a pair of cascaded 2×2 couplers is used to split light along separate sample and reference paths and also for combining light returning from those paths and supplying the interfered collected light to the detection system. The interferometer can be used with various OCT modalities including time-domain and frequency domain approaches.

摘要翻译： 公开了一种配置用于光学相干域（OCT）反射系统的干涉仪。 在优选实施例中，光的有效路由和平衡检测装置提供高的信噪比。 在一组实施例中，使用一对级联的2x2耦合器来沿独立的采样和参考路径分离光，并且还用于组合从那些路径返回的光并将受干扰的收集的光提供给检测系统。 干涉仪可以与各种OCT模式一起使用，包括时域和频域方法。

公开(公告)号：US07400410B2

公开(公告)日：2008-07-15

申请号：US11243665

申请日：2005-10-05

申请人： Chris Baker ,  Matthew J. Everett

发明人： Chris Baker ,  Matthew J. Everett

IPC分类号： G01B11/02 ,  G01B9/02 ,  A61B3/14

CPC分类号： A61B3/102 ,  A61B3/1005 ,  A61B5/0066

摘要： An accurate measure of eye length can be obtained using concurrent OCT measurements. A position OCT device can be used to continually monitor the position of the front surface of the cornea, while a distance OCT device can determine the apparent distance between the front surface of the cornea and the front surface of the retina. Since the eye is likely to move during the period of time between measurements of the cornea and retina, the monitored position of the cornea can be used to correct the apparent length measurement by the amount of eye movement over that period of time, in order to obtain an accurate measure of eye length. In some embodiments a single OCT device can serve the dual role of monitoring eye position while making eye length measurements.

摘要翻译： 使用并行OCT测量可以获得眼睛长度的精确测量。 位置OCT装置可以用于连续监视角膜前表面的位置，而距离OCT装置可以确定角膜前表面和视网膜的前表面之间的表观距离。 由于眼睛可能在角膜和视网膜的测量之间的时间段期间移动，所以可以使用角膜的监视位置来校正视力长度测量量在该时间段内的眼睛移动量，以便 获得眼睛长度的准确度量。 在一些实施例中，单个OCT设备可以起到监视眼睛位置的双重作用，同时进行眼睛长度测量。

公开(公告)号：US08801187B1

公开(公告)日：2014-08-12

申请号：US13250699

申请日：2011-09-30

申请人： Robert W. Knighton ,  Matthew J. Everett ,  Mary K. Durbin ,  Jonathan D. Oakley

发明人： Robert W. Knighton ,  Matthew J. Everett ,  Mary K. Durbin ,  Jonathan D. Oakley

IPC分类号： A61B3/12 ,  G06F17/00 ,  A61B3/10

CPC分类号： A61B3/102 ,  A61B3/0025 ,  G06T7/0012 ,  G06T7/12 ,  G06T7/162 ,  G06T7/60 ,  G06T2207/10101 ,  G06T2207/30041

摘要： Methods for analyzing optical coherence tomography (OCT) images of the macula to reduce variance and improve disease diagnosis are presented. One embodiment of the invention is directed towards selecting analysis locations and data segmentation techniques to take advantage of structural homogeneities. Another embodiment is directed towards reducing the variance in a collection of normative data by transforming the individual members of the database to correspond to a Standard Macula. Variations in foveal size are corrected by radial transformation. Variations in layer thickness are corrected by axial shifting. Diagnosis is performed by comparing OCT images from a patient to the improved normative database.

摘要翻译： 提出了分析黄斑的光学相干断层扫描（OCT）图像以减少变异并改善疾病诊断的方法。 本发明的一个实施例涉及选择分析位置和数据分割技术以利用结构均匀性。 另一个实施例旨在通过将数据库的各个成员变换为对应于标准黄疸来减少规范数据集合中的差异。 通过径向变换校正中心凹大小的变化。 通过轴向移动来校正层厚度的变化。 通过比较患者的OCT图像和改进的规范数据库来进行诊断。

公开(公告)号：US20140081130A1

公开(公告)日：2014-03-20

申请号：US13210129

申请日：2011-08-15

申请人： Matthew J. Everett ,  Jonathan D. Oakley

发明人： Matthew J. Everett ,  Jonathan D. Oakley

IPC分类号： A61B6/00

CPC分类号： A61B6/00 ,  A61B3/0025 ,  A61B3/0041 ,  A61B3/102 ,  A61B3/12 ,  A61B3/1225 ,  A61B3/14

摘要： The present invention relates to structural analysis of the optic nerve head (ONH). In one approach, a 3D volume of intensity data which includes the optic nerve head is acquired using an optical coherence tomography (OCT) system. The vitreoretinal interface (VRI) and the optic disc margin are identified from the 3D data. The minimum area of a surface from the optic disc margin to the VRI is determined. This minimum area can be displayed as an image or in the alternative, a value corresponding to this minimum area can be displayed. The minimum area measurement provides relevant clinical information to determine the health of the eye.

摘要翻译： 本发明涉及视神经头（ONH）的结构分析。 在一种方法中，使用光学相干断层摄影（OCT）系统获取包括视神经头的3D体积的强度数据。 从3D数据识别玻璃体视网膜界面（VRI）和视盘边缘。 确定从光盘边缘到VRI的表面的最小面积。 该最小区域可以显示为图像，或者替代地，可以显示与该最小区域对应的值。 最小面积测量提供相关的临床信息以确定眼睛的健康。

公开(公告)号：US08668338B2

公开(公告)日：2014-03-11

申请号：US13422935

申请日：2012-03-16

申请人： Göran Anders Johansson ,  Matthew J. Everett ,  Christopher J. R. V. Baker

发明人： Göran Anders Johansson ,  Matthew J. Everett ,  Christopher J. R. V. Baker

IPC分类号： A61B3/02

CPC分类号： A61B3/024 ,  A61B3/0285

摘要： Systems and methods for providing variable refractive correction in a visual field testing device are presented. One embodiment of the variable refractive correction involves two or more aligned transmissive plates arranged to produce changes in refractive power by translation or rotation of the plates relative to each other. Several alternative designs for providing variable refractive correction are described. The refractive correction can be set manually or automatically based on knowledge of the refractive error of a specific patient and spherical and cylindrical refractive correction are possible. Additional lens systems can be used to extend the range of refractive correction to accommodate a larger patient population.

摘要翻译： 提出了在视场测试装置中提供可变屈光矫正的系统和方法。 可变屈光矫正的一个实施例涉及两个或多个对准的透射板，其布置成通过平板相对于彼此的平移或旋转产生屈光力的变化。 描述了用于提供可变屈光矫正的几种替代设计。 可以基于对特定患者的屈光不正的知识来手动地或自动地设置屈光矫正，并且可以进行球形和圆柱形折射校正。 可以使用附加的透镜系统来扩展屈光矫正的范围以适应更大的患者群体。

公开(公告)号：US20130070204A1

公开(公告)日：2013-03-21

申请号：US13422935

申请日：2012-03-16

申请人： Göran Anders JOHANSSON ,  Matthew J. Everett ,  Christopher J.R.V. Baker

发明人： Göran Anders JOHANSSON ,  Matthew J. Everett ,  Christopher J.R.V. Baker

IPC分类号： A61B3/024

CPC分类号： A61B3/024 ,  A61B3/0285

摘要： Systems and methods for providing variable refractive correction in a visual field testing device are presented. One embodiment of the variable refractive correction involves two or more aligned transmissive plates arranged to produce changes in refractive power by translation or rotation of the plates relative to each other. Several alternative designs for providing variable refractive correction are described. The refractive correction can be set manually or automatically based on knowledge of the refractive error of a specific patient and spherical and cylindrical refractive correction are possible. Additional lens systems can be used to extend the range of refractive correction to accommodate a larger patient population.

摘要翻译： 提出了在视场测试装置中提供可变屈光矫正的系统和方法。 可变屈光矫正的一个实施例涉及两个或多个对准的透射板，其布置成通过平板相对于彼此的平移或旋转产生屈光力的变化。 描述了用于提供可变屈光矫正的几种替代设计。 可以基于对特定患者的屈光不正的知识来手动地或自动地设置屈光矫正，并且可以进行球形和圆柱形折射校正。 可以使用附加的透镜系统来扩展屈光矫正的范围以适应更大的患者群体。