公开(公告)号：US09364144B2

公开(公告)日：2016-06-14

申请号：US13825786

申请日：2011-08-18

申请人： Martin Hacker ,  Ferid Bajramovic ,  Rico Fuchs ,  Martin Kühner

发明人： Martin Hacker ,  Ferid Bajramovic ,  Rico Fuchs ,  Martin Kühner

IPC分类号： A61B3/14 ,  A61B3/00 ,  A61B3/10 ,  A61B8/08 ,  A61B8/10

CPC分类号： A61B3/102 ,  A61B8/10 ,  A61B8/5238

摘要： The eye is illuminated by a variable laser light source with a measurement range corresponding to the eye length, wherein the focus of the laser beam in the eye can be shifted laterally and/or axially by an adjustment mechanism, and the light fractions back-scattered from the sample are captured via an interferometer by a data acquisition unit and forwarded to a data processing unit. In the data processing unit, an OCT whole-eye scan is combined with at least one or several further overlapping tomographic part-eye or whole-eye scans. Reference information is used to register the first whole-eye scan with the further part-eye or whole-eye scans, and the combined whole-eye scan is evaluated and/or displayed on a user surface.

摘要翻译： 眼睛由具有对应于眼睛长度的测量范围的可变激光光源照射，其中眼睛中的激光束的焦点可以通过调节机构横向和/或轴向地偏移，并且轻分数反向散射 通过数据采集单元经由干涉仪捕获样本，并将其转发到数据处理单元。 在数据处理单元中，将OCT全眼扫描与至少一个或多个进一步重叠的层析成像眼睛或全眼扫描进行组合。 参考信息用于通过进一步的部分眼睛或全眼扫描来注册第一次全眼扫描，并且在用户表面上评估和/或显示组合的全眼扫描。

公开(公告)号：US08801184B2

公开(公告)日：2014-08-12

申请号：US13696030

申请日：2011-04-23

申请人： Martin Hacker ,  Rudolf Murai von Bünau ,  Burkhard Wagner

发明人： Martin Hacker ,  Rudolf Murai von Bünau ,  Burkhard Wagner

IPC分类号： A61B3/14 ,  A61B3/00

CPC分类号： A61B3/102 ,  A61B3/107 ,  A61B5/0066 ,  G01N21/4795 ,  G01N2021/1787

摘要： A system for the improved imaging of eye structures based on optical coherence tomography. The system includes an interferometric measuring arrangement, which has an optical element arranged in the measurement arm or reference arm for influencing the polarization state of the light before the light is interferometrically superimposed, a scanning unit arranged in the measurement arm for implementing OCT scans, a detector for recording the produced interference pattern, and an evaluating and documenting unit. At least two different polarization states of the light are produced. The interference patterns produced in the interferometric measuring arrangement are recorded and forwarded to the evaluating and documenting unit which reconstructs OCT scans from the transmitted interference patterns, combines the OCT scans, and presents and/or stores the resulting OCT signals. The system can be used for pachymetry in addition to the pre- and post-operative imaging for analysis and measurement.

摘要翻译： 一种基于光学相干断层扫描的改善眼结构成像的系统。 该系统包括干涉测量装置，其具有布置在测量臂或参考臂中的光学元件，用于在光被干涉地叠加之前影响光的偏振状态;布置在测量臂中用于实现OCT扫描的扫描单元， 用于记录产生的干涉图案的检测器，以及评估和记录单元。 产生光的至少两种不同的偏振态。 在干涉测量装置中产生的干涉图案被记录并转发给评估和记录单元，其从发射的干涉图案重建OCT扫描，组合OCT扫描，并呈现和/或存储所得到的OCT信号。 除了用于分析和测量的术前和术后成像，该系统可用于深度测量。

公开(公告)号：US08740380B2

公开(公告)日：2014-06-03

申请号：US12858216

申请日：2010-08-17

申请人： Marco Wilzbach ,  Martin Hacker ,  Christoph Hauger

发明人： Marco Wilzbach ,  Martin Hacker ,  Christoph Hauger

IPC分类号： A61B3/00 ,  A61B3/14 ,  A61F2/16

CPC分类号： A61B3/102 ,  A61B5/0066 ,  A61B17/30 ,  A61B90/30 ,  A61F2/16 ,  A61F2/1613 ,  A61F2250/0096 ,  B29D11/023 ,  B82Y20/00 ,  G01B9/02091 ,  G02B5/08 ,  G02B5/22

摘要： An article for use in an OCT method, the article comprising a solid substrate and nanoparticles dispersed in or on the substrate in at least one light transmissive portion of the article such that the nanoparticles result in an increased extinction of the light transmissive portion along a transmission direction of the light transmissive portion compared to the substrate being free of nanoparticles. The extinction of the light transmissive portion along the transmission direction is less than 6, wherein the extinction is defined as a negative decadic logarithm of a ratio of an intensity of light which is transmitted through the light transmissive portion to an intensity of light which is incident on the light transmissive portion, wherein the light is in at least one of a visible and a near infrared wavelength range.

摘要翻译： 一种用于OCT方法的制品，所述制品包含固体基质和纳米颗粒，其分散在所述制品的至少一个透光部分中或所述基底中或基底上，使得所述纳米颗粒导致所述透光部分沿着透射的消光增加 光透射部分的方向与衬底相比没有纳米颗粒。 沿透射方向的光透射部分的消光小于6，其中消光被定义为通过透光部分透射的光的强度与入射光的强度之比的负十进制对数 在所述光透射部分上，其中所述光处于可见光和近红外波长范围中的至少一个。

公开(公告)号：US08717576B2

公开(公告)日：2014-05-06

申请号：US12680722

申请日：2008-09-26

申请人： Martin Hacker

发明人： Martin Hacker

IPC分类号： G01B9/02

CPC分类号： G01B9/02028 ,  A61B3/1005 ,  A61B3/102 ,  A61B3/113 ,  G01B9/02021 ,  G01B9/02035 ,  G01B9/02081 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70 ,  G01N21/4795 ,  G01N2021/1787

摘要： A short coherence interferometer apparatus for measuring multiple axially spaced regions of a specimen, in particular the eye, which has at least one measuring beam path, through which multiple individual measuring beams are incident on the specimen, and one reference beam path, through which a reference beam runs, with which the individual measuring beams are superimposed and brought into interference. The individual measuring beams are axially offset to one another upon incidence on the specimen by an amount which is adapted to the axial spacing. The interferometer apparatus superimposes each individual measuring beam with the reference beam in an interfering manner and conducts it to a detector associated with the particular individual measuring beam. The individual measuring beams are combined into a mixture in which they have varying phasing in the superposition with the reference beam.

摘要翻译： 一种用于测量样本，特别是眼睛的多个轴向间隔的区域的短相干干涉仪装置，其具有至少一个测量光束路径，多个单独的测量光束通过该光束路径入射在样本上，以及一个参考光束路径， 参考光束运行，各个测量光束通过它们叠加并引起干扰。 当在试样上入射适当于轴向间距的量时，各个测量光轴彼此轴向偏移。 干涉仪装置以干扰的方式将每个单独的测量光束与参考光束重叠，并将其传导到与特定的各个测量光束相关联的检测器。 单独的测量光束被组合成混合物，在该混合物中它们与参考光束叠加时具有变化的相位。

公开(公告)号：US08690330B2

公开(公告)日：2014-04-08

申请号：US13140752

申请日：2009-12-21

申请人： Martin Hacker ,  Ralf Ebersbach ,  Thomas Pabst ,  Ulf Peterlein ,  Gerard Antkowiak ,  Roland Bergner ,  Ingo Koschmieder

发明人： Martin Hacker ,  Ralf Ebersbach ,  Thomas Pabst ,  Ulf Peterlein ,  Gerard Antkowiak ,  Roland Bergner ,  Ingo Koschmieder

IPC分类号： A61B3/10

CPC分类号： A61B3/1005 ,  A61B3/102 ,  G01B9/02004 ,  G01B9/0203 ,  G01B9/02067 ,  G01B9/02069 ,  G01B9/02091 ,  G01B2290/45 ,  G01N21/4795

摘要： A device for swept-source optical coherence domain reflectometry (SS OCDR) on moveable samples, particularly human eyes, for obtaining A-scans, having a measuring range according to the sample length and having a laser light source which can be adjusted by a main wave number k0 and at least one receiver for the light dissipated from the sample, wherein the sample is illuminated on the sample surface by a measurement beam having a diameter D by way of a coupling device. The light source has a spectral line width of δk

摘要翻译： 一种用于扫描源光学相干畴反射测量（SS OCDR）的装置，用于可移动的样品，特别是人眼，用于获得A扫描，具有根据样品长度的测量范围，并具有可由主体调节的激光光源 波数k0和用于从样品消散的光的至少一个接收器，其中样品通过耦合装置具有直径D的测量光束照射在样品表面上。 光源的谱线宽度δk<168m-1，光源的调整在τ<44s /（D * k0）内进行。

公开(公告)号：US20130301009A1

公开(公告)日：2013-11-14

申请号：US13884827

申请日：2011-11-09

申请人： Martin Hacker ,  Ferid Bajramovic

发明人： Martin Hacker ,  Ferid Bajramovic

IPC分类号： A61B3/10

CPC分类号： A61B3/102 ,  A61B3/1005 ,  G01B9/02063 ,  G01B9/02089 ,  G01B9/02091

摘要： For the model-based determination of the biometry of eyes, the eye is illuminated by a light source via a scanning unit, the focus of the measuring light beam in the eye is moved or shifted laterally and/or axially via an adjusting device and the light fractions back-scattered by the boundary surfaces and from the tissue of the eye via an interferometer are detected by a sensor and relayed to a control and evaluation unit by which a parametric eye model which describes at least two boundary surfaces present in the eye is adapted to the scan or scans. The invention relates to the field of ophthalmology and serves in particular for the optical determination of the biometry of eyes by application of two-dimensional optical coherence tomography images. However, the method is not limited to the use of coherence tomography nor to the utilisation of optical measurements.

摘要翻译： 对于基于模型的眼睛生物测定的确定，通过扫描单元由光源照射眼睛，眼睛中的测量光束的焦点通过调节装置横向和/或轴向移动或移动，并且 由传感器检测由边界表面和眼睛组织经由干涉仪反向散射的轻分数，并将其转发到控制和评估单元，通过该控制和评估单元描述存在于眼睛中的至少两个边界表面的参数眼模型是 适用于扫描或扫描。 本发明涉及眼科领域，特别用于通过应用二维光学相干断层摄影图像来光学确定眼睛生物测量。 然而，该方法不限于使用相干断层摄影，也不限于使用光学测量。

公开(公告)号：US08363958B2

公开(公告)日：2013-01-29

申请号：US13276203

申请日：2011-10-18

申请人： Matthew J. Everett ,  Claus Flachenecker ,  Martin Hacker ,  Scott A. Meyer ,  Keith E. O'Hara ,  Rick A. Williams

发明人： Matthew J. Everett ,  Claus Flachenecker ,  Martin Hacker ,  Scott A. Meyer ,  Keith E. O'Hara ,  Rick A. Williams

IPC分类号： G06K9/68 ,  G06K9/00

CPC分类号： A61B3/102 ,  A61B3/113

摘要： A line scan imager is used to determine the motion of a subject. Each line of image data from the line scan imager is compared with a reference image. The location of a matching line in the reference image reveals the displacement of the subject. The current subject displacement can be determined based on each line of image data. The resulting displacement information can be used to correctly place other optical beams on the subject. The method can be applied to tracking the human eye to facilitate measurement, imaging, or treatment with a beam of optical radiation.

公开(公告)号：US20120310337A1

公开(公告)日：2012-12-06

申请号：US13483938

申请日：2012-05-30

申请人： Martin Hacker ,  Martin Kuehner ,  Rico Fuchs ,  Matthias Reich

发明人： Martin Hacker ,  Martin Kuehner ,  Rico Fuchs ,  Matthias Reich

IPC分类号： A61F2/16

CPC分类号： A61B3/0025 ,  A61B2034/108 ,  A61F2/1613 ,  G06F19/00 ,  G16H50/50

摘要： Selection of an appropriate intraocular lens (IOL) and/or the applicable surgical parameters for optimizing the results of refractive procedures on the eye. Features of the IOL are crucial for the selection and/or adjustment of the optimal IOL, but so is the IOL selection method (and parameters) from a surgical perspective. For the method, corresponding output parameters are determined from predetermined, estimated, or measured input parameters and/or their mean values, wherein at least two input parameters are varied with one another and which have at least one input parameter as a distribution function. The resulting function is optimized by means of corresponding target values and the determined distribution function of one or more output parameters is used as a decision aid. The present solution is used for selecting an appropriate IOL and/or the applicable surgical parameters and is applicable in the field of eye surgery for implanting IOLs.

摘要翻译： 选择适当的眼内晶状体（IOL）和/或用于优化眼睛屈光程序结果的适用手术参数。 IOL的特征对于最佳IOL的选择和/或调整至关重要，而从手术角度来说，IOL选择方法（和参数）也是至关重要的。 对于该方法，相应的输出参数由预定的，估计的或测量的输入参数和/或它们的平均值确定，其中至少两个输入参数彼此变化并且具有至少一个输入参数作为分布函数。 所得到的函数通过相应的目标值进行优化，并且将一个或多个输出参数的确定的分布函数用作决策辅助。 本解决方案用于选择适当的IOL和/或适用的外科手术参数，并且可用于眼部手术植入IOL的领域。

公开(公告)号：US08085408B2

公开(公告)日：2011-12-27

申请号：US12842935

申请日：2010-07-23

申请人： Matthew J. Everett ,  Martin Hacker

发明人： Matthew J. Everett ,  Martin Hacker

IPC分类号： G01B11/02

CPC分类号： G01B9/02077 ,  A61B3/102 ,  G01B9/0203 ,  G01B9/02044 ,  G01B9/02091 ,  G01B2290/65 ,  G01B2290/70 ,  G01N21/4795

摘要： An optical coherence tomography device is disclosed for improved imaging. Reduced levels of speckle in the images generated by the device are obtained by forming a B-scan from a plurality of A-scans, wherein each resolution cell of the B-scan is generated through compounding of a subset of the A-scans and wherein at least some of the subset of A-scans are separated by at least half the diameter of a speckle cell both tangent to and orthogonal to the B-scan at that cell.

摘要翻译： 公开了一种用于改进成像的光学相干断层摄影装置。 通过从多个A扫描形成B扫描获得由装置产生的图像中的散斑水平的降低，其中B扫描的每个分辨率单元通过A扫描的子集的复合而产生，其中 A扫描的子集中的至少一部分与在该细胞上与B扫描相切且与其正交的斑点细胞的直径的至少一半分开。

公开(公告)号：US20110228218A1

公开(公告)日：2011-09-22

申请号：US13116358

申请日：2011-05-26

申请人： Christoph Hauger ,  Markus Seesselberg ,  Martin Hacker ,  Keith O'Hara

发明人： Christoph Hauger ,  Markus Seesselberg ,  Martin Hacker ,  Keith O'Hara

IPC分类号： A61B3/18 ,  G01B9/02 ,  A61B3/13

CPC分类号： A61B3/102 ,  A61B3/005 ,  A61B3/117 ,  A61B3/12 ,  A61B3/1225 ,  A61B3/13 ,  A61B3/14 ,  G01B9/02004 ,  G01B9/0203 ,  G01B9/02035 ,  G01B9/02044 ,  G01B9/02091 ,  G02B7/14 ,  G02B27/0955

摘要： Imaging systems are provided allowing examination of different object regions spaced apart in a depth direction by visual microscopy and by optical coherence tomography. An axial field of view and a lateral resolution is varied depending on which object region is examined by the imaging system. The proposed imaging systems are in particular applicable for thorough examination of the human eye.

摘要翻译： 提供成像系统，允许通过视觉显微镜和光学相干断层摄影检查在深度方向上间隔开的不同物体区域。 取决于由成像系统检查的对象区域来改变轴向视场和横向分辨率。 所提出的成像系统特别适用于人眼的彻底检查。