公开(公告)号：US09857243B2

公开(公告)日：2018-01-02

申请号：US14660870

申请日：2015-03-17

Applicant: MATRIX SENSORS, INC.

Inventor： Paul R. Wilkinson ,  Steven Yamamoto

IPC: G01L1/10 ,  G01N27/22 ,  G01N33/00 ,  G01N27/416 ,  G01N29/02 ,  G01N29/036 ,  G01N29/24 ,  G01N29/44

CPC classification number: G01L1/10 ,  G01N27/221 ,  G01N27/4163 ,  G01N29/022 ,  G01N29/036 ,  G01N29/2406 ,  G01N29/4427 ,  G01N33/0006 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0427 ,  G01N2291/106

Abstract: An array of resonant sensors self-corrects measured values for the effects of environmental conditions, such as operating temperature, pressure or humidity. The resonant sensors have varied frequency responses to N environmental parameters and M chemical parameters. Each of the sensors has a different, non-zero frequency response to at least two of the parameters. The device also comprises at least one detector for detecting frequency responses of the resonant sensors. Individual parameter values are determined for each of the N environmental parameters and M chemical parameters according to the detected frequency responses and a system of equations using calibration terms that relate the frequency responses to the individual parameter values.

公开(公告)号：US20160282312A1

公开(公告)日：2016-09-29

申请号：US15181117

申请日：2016-06-13

Applicant: MATRIX SENSORS, INC.

Inventor： Michael D Cable ,  Heinrich Sussner ,  Steven Yamamoto

IPC: G01N29/24 ,  G01N33/553 ,  G01N29/036 ,  B05D1/00 ,  G01N29/02 ,  G01N29/028 ,  G01N33/543 ,  G01N33/552

CPC classification number: G01N29/2406 ,  B05D1/005 ,  G01N29/022 ,  G01N29/028 ,  G01N29/036 ,  G01N33/0031 ,  G01N33/54393 ,  G01N33/552 ,  G01N33/553 ,  G01N2291/014 ,  G01N2291/018 ,  G01N2291/021 ,  G01N2291/022 ,  G01N2291/0427 ,  G01N2291/106

Abstract: Surface modifications to sensors in an array give the sensors different functionalities for adsorbing or binding molecules. A method for modifying surfaces of resonant sensors comprises depositing and patterning a first pre-coating material such that the first pre-coating material coats a first one of the resonant sensors and does not coat a second one of the resonant sensors. Both the first and second resonant sensors are then coated with a receptor material. The first resonant sensor that is coated with a combination of the first pre-coating material and the receptor material has a different ability to adsorb or bind a mass of at least one analyte than does the second resonant sensor that is coated with the receptor material without the first pre-coating material. In some examples, an array of sensors is fabricated with N sensors having up to N different pre-coating materials underlying a coating of the same receptor material.

Abstract translation: 对阵列中的传感器的表面改性给传感器提供了吸附或结合分子的不同功能。 用于修改谐振传感器表面的方法包括沉积和图案化第一预涂层材料，使得第一预涂覆材料涂覆第一谐振传感器并且不涂覆第二谐振传感器。 然后用受体材料涂覆第一和第二谐振传感器。 涂覆有第一预涂层材料和受体材料的组合的第一谐振传感器具有不同于吸附或结合至少一种分析物的质量的能力，而不是涂覆有受体材料的第二谐振传感器，而没有 第一预涂料。 在一些实例中，使用具有多达N个不同的预涂层材料的N个传感器制造传感器阵列，其位于同一受体材料的涂层下方。