公开(公告)号：US20140364325A1

公开(公告)日：2014-12-11

申请号：US13911003

申请日：2013-06-05

Applicant: MATRIX SENSORS, INC.

Inventor： Michael D Cable ,  Heinrich Sussner

IPC: G01N33/50

CPC classification number: G01N33/5438 ,  G01N29/022 ,  G01N29/036 ,  G01N29/222 ,  G01N29/2406 ,  G01N33/0031 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0427 ,  G01N2291/106

Abstract: A sensor array includes resonator sensors having respective receptor materials disposed thereon. The receptor materials have a physical property relevant to their ability to bind or adsorb one or more analytes in a sample. The physical property of the receptor materials on the sensors systematically increases or decreases in degree from one sensor to the next in the array. The device also comprises at least one detector for detecting sensor responses when masses of the analytes are adsorbed or bound to the receptor materials on the sensors. With this graded panel of sensors in the array, the analytes may adsorb or bind to the functionalized sensors with a pattern of responses specific to each analyte.

Abstract translation: 传感器阵列包括其上设置有各自的受体材料的谐振器传感器。 受体材料具有与其结合或吸附样品中一种或多种分析物的能力相关的物理性质。 传感器上的受体材料的物理性质系统地从阵列中的一个传感器到下一个传感器的程度增加或减少。 该装置还包括至少一个检测器，用于当大量分析物被吸附或结合到传感器上的受体材料时检测传感器响应。 通过阵列中的这种分级传感器，分析物可以以特定于每种分析物的响应模式吸附或结合功能化传感器。

公开(公告)号：US20160282312A1

公开(公告)日：2016-09-29

申请号：US15181117

申请日：2016-06-13

Applicant: MATRIX SENSORS, INC.

Inventor： Michael D Cable ,  Heinrich Sussner ,  Steven Yamamoto

IPC: G01N29/24 ,  G01N33/553 ,  G01N29/036 ,  B05D1/00 ,  G01N29/02 ,  G01N29/028 ,  G01N33/543 ,  G01N33/552

CPC classification number: G01N29/2406 ,  B05D1/005 ,  G01N29/022 ,  G01N29/028 ,  G01N29/036 ,  G01N33/0031 ,  G01N33/54393 ,  G01N33/552 ,  G01N33/553 ,  G01N2291/014 ,  G01N2291/018 ,  G01N2291/021 ,  G01N2291/022 ,  G01N2291/0427 ,  G01N2291/106

Abstract: Surface modifications to sensors in an array give the sensors different functionalities for adsorbing or binding molecules. A method for modifying surfaces of resonant sensors comprises depositing and patterning a first pre-coating material such that the first pre-coating material coats a first one of the resonant sensors and does not coat a second one of the resonant sensors. Both the first and second resonant sensors are then coated with a receptor material. The first resonant sensor that is coated with a combination of the first pre-coating material and the receptor material has a different ability to adsorb or bind a mass of at least one analyte than does the second resonant sensor that is coated with the receptor material without the first pre-coating material. In some examples, an array of sensors is fabricated with N sensors having up to N different pre-coating materials underlying a coating of the same receptor material.

Abstract translation: 对阵列中的传感器的表面改性给传感器提供了吸附或结合分子的不同功能。 用于修改谐振传感器表面的方法包括沉积和图案化第一预涂层材料，使得第一预涂覆材料涂覆第一谐振传感器并且不涂覆第二谐振传感器。 然后用受体材料涂覆第一和第二谐振传感器。 涂覆有第一预涂层材料和受体材料的组合的第一谐振传感器具有不同于吸附或结合至少一种分析物的质量的能力，而不是涂覆有受体材料的第二谐振传感器，而没有 第一预涂料。 在一些实例中，使用具有多达N个不同的预涂层材料的N个传感器制造传感器阵列，其位于同一受体材料的涂层下方。

公开(公告)号：US09366651B2

公开(公告)日：2016-06-14

申请号：US14322756

申请日：2014-07-02

Applicant: MATRIX SENSORS, INC.

Inventor： Michael D Cable ,  Heinrich Sussner ,  Steven Yamamoto

IPC: G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  G01N29/02 ,  G01N29/028 ,  G01N29/036 ,  G01N29/24

CPC classification number: G01N29/2406 ,  B05D1/005 ,  G01N29/022 ,  G01N29/028 ,  G01N29/036 ,  G01N33/0031 ,  G01N33/54393 ,  G01N33/552 ,  G01N33/553 ,  G01N2291/014 ,  G01N2291/018 ,  G01N2291/021 ,  G01N2291/022 ,  G01N2291/0427 ,  G01N2291/106

Abstract: Surface modifications to sensors in an array give the sensors different functionalities for adsorbing or binding molecules. A first sensor in the array includes a first resonating member having a first surface comprising a receptor material coated over a first underlying material. A second sensor includes a second resonating member having a second surface comprising the receptor material coated over a second underlying material that is different than the first underlying material. The first underlying material, the second underlying material, and the receptor material are selected such that the first resonating member, having a combination of the receptor material and the first underlying material, has a different ability to adsorb or bind a mass of one or more analytes than does the second resonating member having a combination of the receptor material with the second underlying material. Methods for fabricating sensors with surface modifications are also provided.

Abstract translation: 对阵列中的传感器的表面改性给传感器提供了吸附或结合分子的不同功能。 阵列中的第一传感器包括具有第一表面的第一谐振元件，第一谐振元件包括涂覆在第一底层材料上的受体材料。 第二传感器包括具有第二表面的第二谐振元件，该第二表面包括被覆在不同于第一基础材料的第二下层材料上的受体材料。 选择第一基础材料，第二基础材料和受体材料，使得具有受体材料和第一下面材料的组合的第一谐振构件具有不同的吸附或结合一个或多个 分析物比具有受体材料与第二下面材料的组合的第二共振构件相同。 还提供了用于制造具有表面改性的传感器的方法。