公开(公告)号：US20220243278A1

公开(公告)日：2022-08-04

申请号：US17587963

申请日：2022-01-28

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Corporation

Inventor： William R. Taylor ,  Hatim T. Allawi ,  Viatcheslav E. Katerov ,  John B. Kisiel ,  Douglas W. Mahoney ,  David A. Ahlquist

IPC: C12Q1/6886 ,  C12Q1/6806 ,  G01N33/574

Abstract: Provided herein is technology for screening multiple types of cancer from a biological sample, and particularly, but not exclusively, to methods, compositions, and related uses for simultaneously detecting the presence of multiple types of cancer (e.g., liver cancer, esophageal cancer, lung cancer, ovarian cancer, pancreatic cancer, gastric cancer, bladder cancer, breast cancer, cervical cancer, colorectal cancer, prostate cancer, renal cancer, and uterine cancer) from a biological sample (e.g., stool sample, tissue sample, organ secretion sample, CSF sample, saliva sample, blood sample, plasma sample or urine sample).

公开(公告)号：US20210317538A1

公开(公告)日：2021-10-14

申请号：US17347027

申请日：2021-06-14

Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Tracy C. Yab ,  Douglas W. Mahoney

IPC: C12Q1/6886

Abstract: Provided herein is technology for pancreatic high-grade dysplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of pancreatic high-grade dysplasia (IPMN-HGD, PanIN-3, or PDAC).

公开(公告)号：US20210207224A1

公开(公告)日：2021-07-08

申请号：US17205796

申请日：2021-03-18

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Development Company, LLC

Inventor： David A. Ahlquist ,  William R. Taylor ,  Douglas W. Mahoney ,  Tracy C. Yab ,  John B. Kisiel ,  Hatim T. Allawi ,  Graham P. Lidgard ,  Michael W. Kaiser

IPC: C12Q1/6886 ,  C12Q1/6853 ,  G16H50/30 ,  C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/6811 ,  C12Q1/6837 ,  C12Q1/6827 ,  C12Q1/682

Abstract: Provided herein is technology for breast cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of breast cancer.

公开(公告)号：US20210172027A1

公开(公告)日：2021-06-10

申请号：US17178110

申请日：2021-02-17

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Development Company, LLC

Inventor： David A. Ahlquist ,  William R. Taylor ,  Douglas W. Mahoney ,  Tracy C. Yab ,  John B. Kisiel ,  Hatim T. Allawi ,  Graham P. Lidgard ,  Michael W. Kaiser

IPC: C12Q1/6886 ,  C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/6811 ,  C12Q1/6827 ,  C12Q1/6837 ,  C12Q1/6853 ,  G16H50/30 ,  C12Q1/682

Abstract: Provided herein is technology for breast cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of breast cancer.

公开(公告)号：US20210102264A1

公开(公告)日：2021-04-08

申请号：US17120518

申请日：2020-12-14

Applicant: Mayo Foundation for Medical Education and Research

Inventor： John B. Kisiel ,  David A. Ahlquist ,  William R. Taylor ,  Douglas W. Mahoney ,  Tracy C. Yab

IPC: C12Q1/6886

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting neoplasms such as cholangiocarinoma.

公开(公告)号：US10934594B2

公开(公告)日：2021-03-02

申请号：US16202944

申请日：2018-11-28

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Development Company, LLC

Inventor： David A. Ahlquist ,  William R. Taylor ,  Douglas W. Mahoney ,  Tracy C. Yab ,  John B. Kisiel ,  Hatim T. Allawi ,  Graham P. Lidgard ,  Michael W. Kaiser

IPC: C12Q1/68 ,  C07H21/04 ,  C12Q1/6886 ,  C12Q1/6853 ,  G16H50/30 ,  C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/6811 ,  C12Q1/6837 ,  C12Q1/6827 ,  C12Q1/682

Abstract: Provided herein is technology for breast cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of breast cancer.

公开(公告)号：US10704107B2

公开(公告)日：2020-07-07

申请号：US16030313

申请日：2018-07-09

Applicant: Mayo Foundation for Medical Education and Research

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Douglas W. Mahoney ,  Tracy C. Yab

IPC: C12Q1/6886

Abstract: Provided herein is technology for gastrointestinal neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of gastrointestinal neoplasm, and classifying the site location of such a gastrointestinal neoplasm (e.g., a colorectal region, a pancreaticobiliary region, a gastroesophageal region).

公开(公告)号：US20200048720A1

公开(公告)日：2020-02-13

申请号：US16665738

申请日：2019-10-28

Applicant: Exact Sciences Development Company, LLC ,  Mayo Foundation for Medical Education and Research

Inventor： David A. Ahlquist ,  William R. Taylor ,  Hongzhi Zou ,  Graham P. Lidgard

IPC: C12Q1/6886 ,  C12Q1/6858 ,  C12Q1/6827

Abstract: The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.

公开(公告)号：US20190249263A1

公开(公告)日：2019-08-15

申请号：US16399467

申请日：2019-04-30

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Development Company, LLC

Inventor： David A. Ahlquist ,  William R. Taylor ,  Douglas W. Mahoney ,  Graham P. Lidgard ,  Hatim T. Allawi

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.

公开(公告)号：US20190161806A1

公开(公告)日：2019-05-30

申请号：US16202944

申请日：2018-11-28

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Development Company, LLC

Inventor： David A. Ahlquist ,  William R. Taylor ,  Douglas W. Mahoney ,  Tracy C. Yab ,  John B. Kisiel ,  Hatim T. Allawi ,  Graham P. Lidgard ,  Michael W. Kaiser

IPC: C12Q1/6886 ,  C12Q1/6827 ,  C12Q1/682

Abstract: Provided herein is technology for breast cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of breast cancer.