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公开(公告)号：US11702704B2
公开(公告)日：2023-07-18
申请号：US17085542
申请日：2020-10-30
Inventor： William R. Taylor , John B. Kisiel , Douglas W. Mahoney , David A. Ahlquist , Hatim T. Allawi , Michael W. Kaiser
IPC: C12Q1/6886 , C12Q1/6869 , C12N15/117 , G01N33/50
CPC classification number: C12Q1/6886 , C12N15/117 , C12Q1/6869 , G01N33/50 , C12Q2521/301 , C12Q2523/125
Abstract: Provided herein is technology for ovarian cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of ovarian cancer and sub-types of ovarian cancer (e.g., clear cell ovarian cancer, endometrioid ovarian cancer, mucinous ovarian cancer, serous ovarian cancer).
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公开(公告)号：US11697853B2
公开(公告)日：2023-07-11
申请号：US17144806
申请日：2021-01-08
Inventor： David A. Ahlquist , William R. Taylor , John B. Kisiel , Tracy C. Yab , Douglas W. Mahoney , Brian A. Dukek , Matthew T. Gettman , Hatim T. Allawi
IPC: C12Q1/6886
CPC classification number: C12Q1/6886 , C12Q2600/154 , C12Q2600/16
Abstract: Provided herein is technology for prostate cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of prostate cancer.
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公开(公告)号：US20230028856A1
公开(公告)日：2023-01-26
申请号：US17811677
申请日：2022-07-11
Inventor： David A. Ahlquist , William R. Taylor , John B. Kisiel , Douglas W. Mahoney , Tracy C. Yab
IPC: C12Q1/6886
Abstract: Provided herein is technology for gastrointestinal neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of gastrointestinal neoplasm, and classifying the site location of such a gastrointestinal neoplasm (e.g., a colorectal region, a pancreaticobiliary region, a gastroesophageal region).
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公开(公告)号：US11104960B2
公开(公告)日：2021-08-31
申请号：US16570782
申请日：2019-09-13
Applicant: Exact Sciences Development Company, LLC , Mayo Foundation for Medical Education and Research
Inventor： David A. Ahlquist , William R. Taylor , John B. Kisiel , Douglas W. Mahoney , Tracy C. Yab , Graham P. Lidgard , Hatim T. Allawi
IPC: C07H21/04 , C12Q1/68 , C12Q1/6886 , C12Q1/6883 , G01N33/574
Abstract: Provided herein is technology for esophageal disorder screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal disorders (e.g., Barrett's esophagus, Barrett's esophageal dysplasia, etc.). In addition, the technology provides methods, compositions and related uses for distinguishing between Barrett's esophagus and Barrett's esophageal dysplasia, and between Barrett's esophageal low-grade dysplasia, Barrett's esophageal high-grade dysplasia, and esophageal adenocarcinoma within samples obtained through endoscopic brushing or nonendoscopic whole esophageal brushing or swabbing using a tethered device (e.g. such as a capsule sponge, balloon, or other device).
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公开(公告)号：US10683555B2
公开(公告)日：2020-06-16
申请号：US15978565
申请日：2018-05-14
Applicant: Mayo Foundation for Medical Education and Research , EXACT SCIENCES DEVELOPMENT COMPANY, LLC
Inventor： David A. Ahlquist , John B. Kisiel , William R. Taylor , Tracy C. Yab , Douglas W. Mahoney , Graham P. Lidgard , Hatim T. Allawi
IPC: C07H21/04 , C12Q1/68 , C12Q1/6886
Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer.
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Patent Agency Ranking
公开(公告)号：US10184154B2
公开(公告)日：2019-01-22
申请号：US14864158
申请日：2015-09-24
Inventor： John B. Kisiel , David A. Ahlquist , William R. Taylor , Douglas W. Mahoney , Tracy C. Yab
IPC: C12Q1/68 , C12Q1/6886
Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting neoplasms such as cholangiocarinoma.
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公开(公告)号：US20180320240A1
公开(公告)日：2018-11-08
申请号：US16030313
申请日：2018-07-09
Inventor： David A. Ahlquist , William R. Taylor , John B. Kisiel , Douglas W. Mahoney , Tracy C. Yab
IPC: C12Q1/6886
CPC classification number: C12Q1/6886 , C12Q2600/112 , C12Q2600/154
Abstract: Provided herein is technology for gastrointestinal neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of gastrointestinal neoplasm, and classifying the site location of such a gastrointestinal neoplasm (e.g., a colorectal region, a pancreaticobiliary region, a gastroesophageal region).
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公开(公告)号：US20180187270A1
公开(公告)日：2018-07-05
申请号：US15899206
申请日：2018-02-19
Inventor： Hongzhi Zou , David A. Ahlquist
IPC: C12Q1/6886
CPC classification number: C12Q1/6886 , C12Q2600/112 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158
Abstract: The present invention provides methods and materials related to the detection of colorectal neoplasm-specific markers (e.g., markers associated with colorectal cancer, markers associated with adenoma) in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals (e.g., humans) having a colorectal neoplasm by detecting the presence and level of indicators of colorectal neoplasia such as, for example, long DNA (e.g., quantified by Alu PCR) and the presence and level of tumor-associated gene alterations (e.g., mutations in KRAS, APC, melanoma antigen gene, p53, BRAF, BAT26, PIK3CA) or epigenetic alterations (e.g., DNA methylation) (e.g., CpG methylation) (e.g., CpG methylation in coding or regulatory regions of bmp-3, bmp-4, SFRP2, vimentin, septin9, ALX4, EYA4, TFPI2, NDRG4, FOXE1) in DNA from a stool sample obtained from the mammal.
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公开(公告)号：US09994911B2
公开(公告)日：2018-06-12
申请号：US14775435
申请日：2014-03-12
Applicant: Mayo Foundation for Medical Education and Research , EXACT SCIENCES DEVELOPMENT COMPANY, LLC
Inventor： David A. Ahlquist , John B. Kisiel , William R. Taylor , Tracy C. Yab , Douglas W. Mahoney , Graham P. Lidgard , Hatim T. Allawi
CPC classification number: C12Q1/6886 , C12Q2600/112 , C12Q2600/154
Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer. Accordingly, provided herein is technology for pancreatic cancer screening markers and other gastrointestinal cancer screening markers that provide a high signal to-noise ratio and a low background level when detected from samples taken from a subject (e.g., stool sample). As described herein, the technology provides a number of methylated DNA markers and subsets thereof (e.g., sets of 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or more markers) with high discrimination for G1 neoplasms overall and/or at individual tumor sites.
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公开(公告)号：US09803249B2
公开(公告)日：2017-10-31
申请号：US15467739
申请日：2017-03-23
Inventor： William R. Taylor , Jonathan J. Harrington , Patrick S. Quint , Hongzhi Zou , Harold S. Bergen, III , David I. Smith , David A. Ahlquist
IPC: C12Q1/68 , G01N33/574
CPC classification number: C12Q1/6886 , C12Q1/37 , C12Q1/40 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Y302/01001 , C12Y304/2107 , G01N33/57407 , G01N33/57419 , G01N33/57438 , G01N2333/928 , G01N2333/966 , G01N2560/00
Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.
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