公开(公告)号：US20170168070A1

公开(公告)日：2017-06-15

申请号：US15388358

申请日：2016-12-22

Applicant: Meso Scale Technologies, LLC. ,  Crescendo Bioscience ,  Oklahoma Medical Research Foundation

Inventor： Pankaj Oberoi ,  Steven C. Hoffmann ,  Guy L. Cavet ,  Yijing Shen ,  Nicholas Knowlton ,  Michael Centola

IPC: G01N33/68 ,  G06F19/24

CPC classification number: G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/53 ,  G01N33/564 ,  G01N2333/4709 ,  G01N2333/4737 ,  G01N2333/475 ,  G01N2333/485 ,  G01N2333/5412 ,  G01N2333/70503 ,  G01N2333/70578 ,  G01N2333/72 ,  G01N2333/96494 ,  G01N2800/102 ,  G01N2800/60 ,  G16B40/00

Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).

公开(公告)号：US20170074878A1

公开(公告)日：2017-03-16

申请号：US15363991

申请日：2016-11-29

Applicant: Meso Scale Technologies, LLC. ,  Crescendo Bioscience ,  Oklahoma Medical Research Foundation

Inventor： Pankaj Oberoi ,  Steven C. Hoffmann ,  Guy L. Cavet ,  Yijing Shen ,  Nicholas Knowlton ,  Michael Centola

IPC: G01N33/564

CPC classification number: G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/53 ,  G01N33/564 ,  G01N2333/4709 ,  G01N2333/4737 ,  G01N2333/475 ,  G01N2333/485 ,  G01N2333/5412 ,  G01N2333/70503 ,  G01N2333/70578 ,  G01N2333/72 ,  G01N2333/96494 ,  G01N2800/102 ,  G01N2800/60 ,  G16B40/00

Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).

Abstract translation: 提供了用于诊断和评估炎性疾病的生物标志物，以及用于测量其表达的试剂盒。 本发明还提供了基于生物标志物的预测模型，以及用于评分和可选地分类样品的模型的计算机系统和软件实施方案。 生物标志物包括至少两种选自DAIMRK组的生物标志物，得分是疾病活动指数（DAI）。

公开(公告)号：US11951483B2

公开(公告)日：2024-04-09

申请号：US17215962

申请日：2021-03-29

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Sudeep Kumar ,  Pankaj Oberoi ,  George Sigal ,  Michael Tsionsky

IPC: G01N33/543 ,  B01L3/00 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6876 ,  G01N33/68

CPC classification number: B01L3/50853 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6876 ,  G01N33/54306 ,  G01N33/54353 ,  G01N33/6845 ,  B01L2300/021 ,  B01L2300/043 ,  B01L2300/0609 ,  B01L2300/0829 ,  G01N2458/10 ,  C12Q1/6816 ,  C12Q2563/131

Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

公开(公告)号：US10189023B2

公开(公告)日：2019-01-29

申请号：US14203638

申请日：2014-03-11

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Sudeep Kumar ,  Pankaj Oberoi ,  George Sigal ,  Michael Tsionsky

IPC: C07H21/04 ,  B01L3/00 ,  C12Q1/6876 ,  G01N33/543 ,  C12Q1/6804 ,  G01N33/68 ,  C12Q1/6816

Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

公开(公告)号：US20180292419A1

公开(公告)日：2018-10-11

申请号：US16012992

申请日：2018-06-20

Applicant: Meso Scale Technologies, LLC.

Inventor： Robert M. Umek ,  Pankaj Oberoi

IPC: G01N33/68

CPC classification number: G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821 ,  G01N2800/52

Abstract: Described are assay methods, modules and kits useful in the detection, treatment and/or prevention of dementia and related conditions, including but not limited to Alzheimer's disease and mild cognitive disorders.

公开(公告)号：US10024871B2

公开(公告)日：2018-07-17

申请号：US15581143

申请日：2017-04-28

Applicant: Meso Scale Technologies, LLC.

Inventor： Robert M. Umek ,  Pankaj Oberoi

IPC: G01N33/68

Abstract: Described are assay methods, modules and kits useful in the detection, treatment and/or prevention of dementia and related conditions, including but not limited to Alzheimer's disease and mild cognitive disorders.

公开(公告)号：US20170234892A1

公开(公告)日：2017-08-17

申请号：US15581143

申请日：2017-04-28

Applicant: Meso Scale Technologies, LLC.

Inventor： Robert M. Umek ,  Pankaj Oberoi

IPC: G01N33/68

CPC classification number: G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821 ,  G01N2800/52

Abstract: Described are assay methods, modules and kits useful in the detection, treatment and/or prevention of dementia and related conditions, including but not limited to Alzheimer's disease and mild cognitive disorders.