公开(公告)号：US20170122907A1

公开(公告)日：2017-05-04

申请号：US15318271

申请日：2015-05-29

Applicant: Micromass UK Limited

Inventor： Martin Raymond GREEN ,  Jason Lee WILDGOOSE

IPC: G01N27/62 ,  H01J49/42 ,  H01J49/04 ,  H01J49/00

CPC classification number: G01N27/624 ,  H01J49/0031 ,  H01J49/0422 ,  H01J49/421

Abstract: A mass spectrometer or ion mobility spectrometer is disclosed comprising: a first device for separating ions or molecules according to a physicochemical property; an ion mobility separation device for receiving and separating at least some of said ions or ions derived from said molecules according to their ion mobility; a gas supply connected to said ion mobility separation device for supplying gas into said ion mobility separation device; and a control system configured to adjust said gas supply so as to change the composition of gas within the ion mobility separation device as a function of time.

公开(公告)号：US20170069478A1

公开(公告)日：2017-03-09

申请号：US15357461

申请日：2016-11-21

Applicant: Micromass UK Limited

Inventor： Jeffery Mark BROWN ,  Martin Raymond GREEN ,  Steven Derek PRINGLE

IPC: H01J49/12 ,  H01J49/04 ,  H01J49/00

Abstract: A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode located within an isolation valve, which is provided in the vacuum chamber. Reagent vapour may be provided through the tubular electrode, which is then subsequently ionised by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.

Abstract translation: 公开了质谱仪，其包括在质谱仪的初始真空室内的辉光放电装置。 辉光放电装置可以包括设置在真空室内的隔离阀内的管状电极。 试剂蒸气可以通过管状电极提供，然后其随后通过辉光放电电离。 所得的试剂离子可用于由大气压离子源产生的分析物离子的电子转移离解。 考虑其他实施例，其中由辉​​光放电装置产生的离子可用于通过质子转移反应来减少分析物离子的电荷状态，或者可以作为锁定质量或参考离子。