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    Intelligent Dynamic Range Enhancement
    3.
    发明申请
    Intelligent Dynamic Range Enhancement 审中-公开

    公开(公告)号：US20170229297A1

    公开(公告)日：2017-08-10

    申请号：US15434517

    申请日：2017-02-16

    Applicant: Micromass UK Limited

    Inventor： Martin Raymond GREEN ,  Steven Derek PRINGLE ,  Jason Lee WILDGOOSE

    IPC: H01J49/06 ,  H01J49/00

    CPC classification number: H01J49/061 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/025 ,  H01J49/10 ,  H01J49/40

    Abstract: A method of mass spectrometry is disclosed comprising transmitting ions and obtaining first mass spectral data and automatically determining during an acquisition whether the first mass spectral data suffers from saturation or is approaching saturation. If a determination is made during an acquisition that the first mass spectral data suffers from saturation or is approaching saturation then the method further comprises automatically changing or altering the intensity of ions which are detected by an ion detector and obtaining second mass spectral data. The method further comprises substituting one or more portions of the first mass spectral data with one or more corresponding portions of the second mass spectral data multiplied or scaled by an attenuation or scale factor and/or by an integer or other value so as to form a composite mass spectrum, wherein the composite mass spectrum comprises one or more ion peaks from the first mass spectral data and one or more ion peaks from the second mass spectral data.

    Glow Discharge Ion Source
    5.
    发明申请
    Glow Discharge Ion Source 审中-公开
    辉光放电离子源

    公开(公告)号：US20170069478A1

    公开(公告)日：2017-03-09

    申请号：US15357461

    申请日：2016-11-21

    Applicant: Micromass UK Limited

    Inventor： Jeffery Mark BROWN ,  Martin Raymond GREEN ,  Steven Derek PRINGLE

    IPC: H01J49/12 ,  H01J49/04 ,  H01J49/00

    Abstract: A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode located within an isolation valve, which is provided in the vacuum chamber. Reagent vapour may be provided through the tubular electrode, which is then subsequently ionised by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.

    Abstract translation: 公开了质谱仪，其包括在质谱仪的初始真空室内的辉光放电装置。 辉光放电装置可以包括设置在真空室内的隔离阀内的管状电极。 试剂蒸气可以通过管状电极提供，然后其随后通过辉光放电电离。 所得的试剂离子可用于由大气压离子源产生的分析物离子的电子转移离解。 考虑其他实施例，其中由辉​​光放电装置产生的离子可用于通过质子转移反应来减少分析物离子的电荷状态，或者可以作为锁定质量或参考离子。

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