公开(公告)号：US20240153752A1

公开(公告)日：2024-05-09

申请号：US18500982

申请日：2023-11-02

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Jona THALMANN ,  Hans-Jürgen SCHLÜTER ,  Benno STRASSER ,  Norbert QUAAS

IPC: H01J49/10 ,  H01J49/00 ,  H01J49/42

CPC classification number: H01J49/105 ,  H01J49/0027 ,  H01J49/421

Abstract: Methods for operating a mass spectrometer having a skimmer and a circuit configured to apply an electric potential to the skimmer comprise obtaining an initial mass spectrum of a sample and measuring a value indicating an ion beam intensity of one or more ion species. A varying DC electric potential is applied to the skimmer to identify an operational electric potential, wherein the DC electric potential is varied until the value indicating the ion beam intensity of the one or more ion species changes by a predetermined amount. The mass spectrum with the operational electric potential applied to the skimmer is output. In some examples, a pressure within the mass spectrometer is varied to identify an operational pressure, and the mass spectrum with the pressure within the mass spectrometer at the operational pressure is output.

公开(公告)号：US11875981B2

公开(公告)日：2024-01-16

申请号：US17810305

申请日：2022-06-30

Applicant: Thermo Finnigan LLC

Inventor： Michael W. Senko ,  Philip M. Remes

IPC: H01J49/00 ,  H01J49/42 ,  G01N27/622

CPC classification number: H01J49/0031 ,  G01N27/622 ,  H01J49/0072 ,  H01J49/421 ,  H01J49/4225

Abstract: A method of operating a mass spectrometer that allows for high-speed operation is disclosed. The method consists in separating the various steps needed to produce a mass spectrum into three or more conceptual stages in a pipeline, such that the instrument is performing steps to process more than two precursor-ion species simultaneously. In general, the number of stages in the pipeline should at least one more and, preferably, at least two more than the number of buffering storage devices in the instrument. The presently-taught methods and apparatus allow for nearly 100% duty cycle of ion accumulation for precursors of interest.

公开(公告)号：US11862450B2

公开(公告)日：2024-01-02

申请号：US17612092

申请日：2020-05-19

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Henning Wehrs ,  Johannes Schwieters ,  Gerhard Jung

IPC: H01J49/10 ,  H01J49/42 ,  H01J49/06 ,  H01J49/00 ,  H01J49/02 ,  F16K1/20

CPC classification number: H01J49/063 ,  F16K1/2007 ,  H01J49/005 ,  H01J49/0077 ,  H01J49/022 ,  H01J49/065 ,  H01J49/067 ,  H01J49/068 ,  H01J49/105 ,  H01J49/421 ,  H01J49/4215

Abstract: An ion optical arrangement (1) for use in a mass spectrometer comprises a collision cell defining an ion optical axis along which ions may pass, electrodes comprising a set of parallel poles (11A, 11B, 11C) arranged in the collision cell, and a voltage source for providing voltages to the electrodes to produce electric fields. The ion optical arrangement is arranged for switching between a first operation mode in which the collision cell is pressurized and a second operation mode in which the collision cell is substantially evacuated. The ion optical arrangement is further arranged for producing a radio frequency electric focusing field in the first operation mode and a static electric focusing field in the second operation mode.

公开(公告)号：US20180166262A1

公开(公告)日：2018-06-14

申请号：US15576980

申请日：2016-05-31

Applicant: MICROMASS UK LIMITED

Inventor： Richard Moulds

IPC: H01J49/00 ,  H01J49/36 ,  H01J49/06 ,  H01J49/42

CPC classification number: H01J49/0031 ,  H01J49/061 ,  H01J49/36 ,  H01J49/421 ,  H01J49/4215

Abstract: A method of mass spectrometry is disclosed comprising detecting the ions transmitted by a mass filter (4) with a detector (6); changing the RF and/or DC voltage applied to the mass filter (4) during a voltage transition period so as to change the mass to charge ratio capable of being transmitted by the mass filter (4); preventing ions from reaching the detector during the voltage transition period; and allowing ions to be transmitted to the detector (6) after the voltage transition period.

公开(公告)号：US20180144922A1

公开(公告)日：2018-05-24

申请号：US15715523

申请日：2017-09-26

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Tak Shun Cheung ,  Chui Ha Cindy Wong

IPC: H01J49/42 ,  H01J1/02

CPC classification number: H01J49/421 ,  H01G4/0085 ,  H01G4/012 ,  H01G4/105 ,  H01G4/129 ,  H01G4/30 ,  H01G4/38 ,  H01J1/02 ,  H01J49/022 ,  H01J49/063 ,  H01J49/4215

Abstract: Certain configurations of a stable capacitor are described which comprise electrodes produced from materials comprising a selected coefficient of thermal expansion to enhance stability. The electrodes can be spaced from each other through one of more dielectric layers or portions thereof. In some instances, the electrodes comprise integral materials and do not include any thin films. The capacitors can be used, for example, in feedback circuits, radio frequency generators and other devices used with mass filters and/or mass spectrometry devices.

公开(公告)号：US20180068837A1

公开(公告)日：2018-03-08

申请号：US15796515

申请日：2017-10-27

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Alexander Alekseevich MAKAROV

IPC: H01J49/00 ,  H01J49/40

CPC classification number: H01J49/005 ,  H01J49/0036 ,  H01J49/0077 ,  H01J49/009 ,  H01J49/40 ,  H01J49/421 ,  H01J49/425

Abstract: A mass spectrometer comprises: an ion source that generates ions having an initial range of mass-to-charge ratios; an auxiliary ion detector, downstream from the ion source that receives a plurality of first ion samples derived from the ions generated by the ion source and determines a respective ion current measurement for each of the plurality of first ion samples; a mass analyser, downstream from the ion source that receives a second ion sample derived from the ions generated by the ion source and to generate mass spectral data by mass analysis of the second ion sample; and an output stage that establishes an abundance measurement associated with at least some of the ions generated by the ion source based on the ion current measurements determined by the auxiliary ion detector.

公开(公告)号：US09881778B2

公开(公告)日：2018-01-30

申请号：US15304668

申请日：2015-04-17

Applicant: MICROMASS UK LIMITED

Inventor： Jeffery Mark Brown

IPC: H01J49/00 ,  G01N27/62 ,  H01J49/42

CPC classification number: H01J49/0031 ,  G01N27/622 ,  H01J49/004 ,  H01J49/005 ,  H01J49/0072 ,  H01J49/421

Abstract: A method is disclosed wherein parent or precursor ions are fragmented or reacted according to a first fragmentation or reaction mode, and when an ion of interest is detected the method then temporarily switches to a second mode of fragmentation or reaction. This enables a full un-biased MS/MS data set to be provided over a wide mass to charge ratio range with high-duty cycle, together with complementary detailed fragment data of interest, in a single experimental run or acquisition.

公开(公告)号：US20170140914A1

公开(公告)日：2017-05-18

申请号：US15338727

申请日：2016-10-31

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Henning WEHRS

IPC: H01J49/10 ,  H01J49/14 ,  H01J49/42 ,  H01J49/00

CPC classification number: H01J49/105 ,  H01J49/0027 ,  H01J49/0077 ,  H01J49/14 ,  H01J49/421

Abstract: Disclosed is a method of inductively coupled plasma mass spectrometry (ICP-MS), comprising steps of introducing at least one sample comprising at least one sample species, and at least one reactive species, into an inductively coupled plasma source, such that at least one molecular adduct ion of the at least one reactive species and the at least one sample species is formed; transferring the at least one molecular adduct ion into a collision cell that is arranged between the inductively coupled plasma source and at least one mass analyzer, transferring the at least one molecular adduct ion, or a product thereof, into the at least one mass analyzer, and analyzing the mass of the at least one molecular adduct ion, or the product thereof, in the at least one mass analyzer. Also disclosed is a mass spectrometer that is adapted to perform the method.

公开(公告)号：US20170045477A1

公开(公告)日：2017-02-16

申请号：US15337937

申请日：2016-10-28

Applicant: Ownstone Medical Limited

Inventor： Matthew Hart ,  Andrew H. Koehl

IPC: G01N27/62

CPC classification number: G01N27/622 ,  G01N27/624 ,  H01J49/421

Abstract: An ion filter and a method of manufacturing an ion filter. The method including providing a monolithic structure; selectively removing regions of the structure, to form a pair of electrodes defining at least one ion channel therebetween. The electrodes are preferably mechanically connected at one or more locations by a portion of the structure; wherein the connecting portion of the structure provides a higher electrical impedance than the filter would provide without such a mechanical connection, to thereby electrically separate the electrodes.

Abstract translation: 离子过滤器和离子过滤器的制造方法。 该方法包括提供整体结构; 选择性地去除所述结构的区域，以形成在其间限定至少一个离子通道的一对电极。 电极优选通过结构的一部分在一个或多个位置处机械连接; 其中结构的连接部分提供比过滤器提供的更高的电阻抗，而不需要这种机械连接，从而电分离电极。

公开(公告)号：US09570279B2

公开(公告)日：2017-02-14

申请号：US14768048

申请日：2014-02-07

Applicant: OFFICE TANDEM L.L.C.

Inventor： Masanao Hotta ,  Tatsuya Adachi

IPC: H01J49/06 ,  H01J37/05 ,  H01J49/42 ,  H01J49/26 ,  H01J49/36 ,  H01J37/244 ,  H01J37/252

CPC classification number: H01J49/06 ,  H01J37/05 ,  H01J37/244 ,  H01J37/252 ,  H01J49/26 ,  H01J49/36 ,  H01J49/421

Abstract: A mass analyzer includes two rotating electric field (REF) units, sinusoidal signal generators and a means for separation of dispersed ions. The REF units include a plurality of elongated electrodes surrounding a central axis, and are lined in tandem at elongated direction. Sinusoidal signals are applied to the electrodes to rotate electric fields within each REF unit. The means for separation is placed adjacent the downstream end of the 2nd REF unit. Ions enter the 1st REF unit, diverge outwards and leave the 1st REF unit on off-axis positions. The ions successively enter the 2nd REF unit and converge inwards because of 180 degrees phase difference from the 1st REF unit. Specified mass ions return to and travel along the central axis. However, unspecified mass ions deviate from the central axis and travel apart from the central axis. The means for separation separates specified ions from unspecified ions.

Abstract translation: 质量分析仪包括两个旋转电场（REF）单元，正弦信号发生器和用于分离分散离子的装置。 REF单元包括围绕中心轴线的多个细长电极，并且在细长方向上串联排列。 正弦信号施加到电极以旋转每个REF单元内的电场。 分离装置靠近第二个REF单元的下游端。 离子进入第一个REF单元，向外发散，并将第一个REF单元留在离轴位置。 与第一个REF单元相差180度，离子依次进入第二个REF单元并向内收敛。 指定的质量离子返回并沿着中心轴线行进。 然而，未指定的质量离子偏离中心轴线并与中心轴线分开。 分离装置将指定的离子与未指定的离子分开。