公开(公告)号：US20130168941A1

公开(公告)日：2013-07-04

申请号：US13822040

申请日：2011-08-08

申请人： Kazuki Takagi ,  Makoto Kihara ,  Masanori Hayashi ,  Noriaki Masuda

发明人： Kazuki Takagi ,  Makoto Kihara ,  Masanori Hayashi ,  Noriaki Masuda

IPC分类号： B60G15/06

CPC分类号： B60G15/067 ,  B60G13/003 ,  B60G15/063 ,  B60G15/068 ,  B60G2204/128 ,  B60G2204/41 ,  F16F1/3732 ,  F16F1/3735 ,  F16F9/54

摘要： A damper mounting structure is provided with a top buffer member and a bottom buffer member. The bottom buffer member has a protruding section that protrudes with an outer diameter smaller than the outer diameter of the bottom buffer member. The damper mounting structure mates with the protruding section and is anchored to a vehicle body panel, and is provided with a collar formed at substantially the same height as the height of the protruding section. The corner of an opening formed on the vehicle body panel, which comes into contact with the top buffer member, is chamfered.

摘要翻译： 阻尼器安装结构设置有顶部缓冲构件和底部缓冲构件。 底部缓冲构件具有突出部，突出部的外径小于底部缓冲部件的外径。 阻尼器安装结构与突出部分配合并且被锚固到车体面板上，并且设置有与突出部分的高度基本相同的高度形成的套环。 与顶部缓冲构件接触的车身面板上形成的开口的角部被倒角。

公开(公告)号：US20100062089A1

公开(公告)日：2010-03-11

申请号：US12531079

申请日：2008-03-13

申请人： Shigeki Araki ,  Makoto Kihara ,  Chikako Shimizu ,  Hiroshi Hirata ,  Sachie Ikegami ,  Seiichiro Aoe

发明人： Shigeki Araki ,  Makoto Kihara ,  Chikako Shimizu ,  Hiroshi Hirata ,  Sachie Ikegami ,  Seiichiro Aoe

IPC分类号： A61K36/899

CPC分类号： A21D13/02 ,  A21D2/36 ,  A23K10/37 ,  A23L2/38 ,  A23L2/52 ,  A23L7/115 ,  A23L33/105 ,  A23L33/21 ,  A23V2002/00 ,  A61K36/8998 ,  Y02P60/877 ,  A23V2200/328 ,  A23V2250/5106

摘要： The present invention provides an ameliorative or preventive agent for metabolic syndrome comprising a barley bran or an α-amylase-treated product thereof as an active ingredient. The present invention also provides an ameliorative or preventive agent for metabolic syndrome comprising a water-insoluble component of an α-amylase-treated product of a barley bran as an active ingredient. These are naturally derived ameliorative or preventive agents for metabolic syndrome which can inhibit the accumulation of visceral fat to ameliorate or prevent metabolic syndrome.

摘要翻译： 本发明提供一种代谢综合症的改善或预防剂，其包含作为活性成分的大麦麸或其α-淀粉酶处理产物。 本发明还提供一种代谢综合症的改善或预防剂，其包含作为活性成分的大麦麸的α-淀粉酶处理产品的水不溶性成分。 这些是天然衍生的代谢综合征改善剂或预防剂，其可以抑制内脏脂肪的积累以改善或预防代谢综合征。

公开(公告)号：US20090035415A1

公开(公告)日：2009-02-05

申请号：US12147280

申请日：2008-06-26

申请人： Kazuyoshi Takeda ,  Takafumi Kaneko ,  Makoto Kihara ,  Takashi Asakura ,  Kazutoshi Ito

发明人： Kazuyoshi Takeda ,  Takafumi Kaneko ,  Makoto Kihara ,  Takashi Asakura ,  Kazutoshi Ito

IPC分类号： C12C1/00 ,  C12Q1/68 ,  C12N15/56

CPC分类号： C12N9/2425 ,  A01H1/04 ,  A01H5/10 ,  C12P7/14 ,  C12P19/22 ,  C12Q1/40 ,  C12Y302/01002

摘要： A method of selecting a barley variety comprising: a heat treatment step of heat-treating a crude enzyme solution extracted from a seed of a barley (e.g., at 57.5° C. for 30 minutes); an activity-determining step of determining the enzyme activity of β-amylase in the crude enzyme solution heat-treated; and a selection step of selecting the barley variety containing a β-amylase having a residual activity of from 85 to 90% as a result of the activity determination.

摘要翻译： 一种选择大麦品种的方法，包括：热处理从大麦种子提取的粗酶溶液（例如在57.5℃下热处理30分钟）的热处理步骤; 确定热处理粗酶溶液中β-淀粉酶的酶活性的活性测定步骤; 以及作为活性测定的结果，选择含有残留活性为85〜90％的β-淀粉酶的大麦品种的选择步骤。

公开(公告)号：US07074986B1

公开(公告)日：2006-07-11

申请号：US10048987

申请日：2000-08-16

申请人： Naohiko Hirota ,  Makoto Kihara ,  Kazutoshi Ito

发明人： Naohiko Hirota ,  Makoto Kihara ,  Kazutoshi Ito

IPC分类号： A01H5/00 ,  C12N15/82

CPC分类号： C12N15/8242 ,  C07K14/415 ,  C12N15/8251

摘要： In barley, the formation of D-hordein constituting gel protein is to be reduced. This reduction in the formation of D-hordein causes a reduction of gel protein because D-hordein fraction decreases in the gel protein; and in addition, it brings about the transformation (reduction) of proteins other than D-hordein which constitute the gel protein from the gel protein. Therefore, by introducing into barley D-hordein expression suppressing vector 1 capable of suppressing the D-hordein formation and transforming the barley therewith, it is possible to attain the reduction of gel protein based on the reduction in the D-hordein formation.

摘要翻译： 在大麦中，减少构成凝胶蛋白的D-大麦醇溶蛋白的形成。 这种形成D-大麦醇溶蛋白的减少导致凝胶蛋白质的减少，因为D-大麦醇溶蛋白部分在凝胶蛋白中降低; 此外，还引起了来自凝胶蛋白质的构成凝胶蛋白质的除了大麦醇溶蛋白以外的蛋白质的转化（降低）。 因此，通过将能够抑制D-大麦芽糖苷形成和大麦转化的大麦醇溶蛋白表达抑制载体1导入，可以基于D-大麦醇溶蛋白形成的降低而获得凝胶蛋白质的还原。

公开(公告)号：US5641868A

公开(公告)日：1997-06-24

申请号：US427862

申请日：1995-04-26

申请人： Shingou Sakurai ,  Masanobu Naruto ,  Makoto Kihara ,  Keizo Hanada ,  Emiko Sano ,  Shigeru Ichikura ,  Jun Utsumi ,  Kazuo Hosoi

发明人： Shingou Sakurai ,  Masanobu Naruto ,  Makoto Kihara ,  Keizo Hanada ,  Emiko Sano ,  Shigeru Ichikura ,  Jun Utsumi ,  Kazuo Hosoi

IPC分类号： C07K14/54 ,  C07K1/16 ,  A61K38/20 ,  C12P21/00

CPC分类号： C07K14/5412

摘要： The present invention relates to compositions containing human interleukin-6 with sugar chains, a process for preparing human interleukin-6 by culturing cells in a medium containing ascorbic acid or any of its derivatives, and a process for purifying a crude raw human interleukin-6 solution by chromatography using a carrier with heparin bound. The present invention has allowed the production of high quality human interleukin-6 compositions with sugar chains, and their application to medicines. Furthermore, it has established a process for massproducing human interleukin-6.

摘要翻译： 本发明涉及含有人白细胞介素-6与糖链的组合物，通过在含有抗坏血酸或其任何衍生物的培养基中培养细胞来制备人白细胞介素-6的方法，以及纯化粗制人白细胞介素-6 使用带有肝素结合的载体的色谱法。 本发明允许生产具有糖链的高品质人白细胞介素-6组合物及其在药物中的应用。 此外，它已经建立了大量生产人白细胞介素-6的过程。

公开(公告)号：US08915539B2

公开(公告)日：2014-12-23

申请号：US14130641

申请日：2012-06-29

申请人： Kiyohiko Matsuoka ,  Shigetaka Kameyama ,  Makoto Kihara

发明人： Kiyohiko Matsuoka ,  Shigetaka Kameyama ,  Makoto Kihara

IPC分类号： B60S1/04 ,  B62D25/08

CPC分类号： B62D25/08 ,  B62D25/081

摘要： A structure for a front portion of a vehicle is provided with a windshield lower member. The windshield lower member includes a windshield lower member main body, and an extended portion formed so as to extend frontward from a front end portion of the windshield lower member main body. The extended portion includes a base portion formed so as to continue from a front end portion of the windshield lower member main body, a weight portion extending in an obliquely front-upward direction from a front end portion of the base portion, and a weak portion that extends in a vehicle width direction at a boundary between the base portion and the weight portion, and that has lower rigidity than the base portion.

摘要翻译： 车辆前部的结构设置有挡风玻璃下部构件。 挡风玻璃下部构件包括挡风玻璃下部构件主体和形成为从挡风玻璃下部构件主体的前端部向前延伸的延伸部。 所述延伸部包括形成为从所述挡风玻璃下部构件主体的前端部延伸的基部，从所述基部的前端部向斜前方向延伸的配重部， 其在基部和重物部分之间的边界处沿车宽方向延伸，并且具有比基部低的刚性。

公开(公告)号：US20140117720A1

公开(公告)日：2014-05-01

申请号：US14130641

申请日：2012-06-29

申请人： Kiyohiko Matsuoka ,  Shigetaka Kameyama ,  Makoto Kihara

发明人： Kiyohiko Matsuoka ,  Shigetaka Kameyama ,  Makoto Kihara

IPC分类号： B62D25/08

CPC分类号： B62D25/08 ,  B62D25/081

摘要： A structure for a front portion of a vehicle is provided with a windshield lower member. The windshield lower member includes a windshield lower member main body, and an extended portion formed so as to extend frontward from a front end portion of the windshield lower member main body. The extended portion includes a base portion formed so as to continue from a front end portion of the windshield lower member main body, a weight portion extending in an obliquely front-upward direction from a front end portion of the base portion, and a weak portion that extends in a vehicle width direction at a boundary between the base portion and the weight portion, and that has lower rigidity than the base portion.

摘要翻译： 车辆前部的结构设置有挡风玻璃下部构件。 挡风玻璃下部构件包括挡风玻璃下部构件主体和形成为从挡风玻璃下部构件主体的前端部向前延伸的延伸部。 所述延伸部包括形成为从所述挡风玻璃下部构件主体的前端部延伸的基部，从所述基部的前端部向斜前方向延伸的配重部， 其在基部和重物部分之间的边界处沿车宽方向延伸，并且具有比基部低的刚性。

公开(公告)号：US08668213B2

公开(公告)日：2014-03-11

申请号：US13822040

申请日：2011-08-08

申请人： Kazuki Takagi ,  Makoto Kihara ,  Masanori Hayashi ,  Noriaki Masuda

发明人： Kazuki Takagi ,  Makoto Kihara ,  Masanori Hayashi ,  Noriaki Masuda

IPC分类号： B60G15/04 ,  B60G15/06 ,  F16F9/54 ,  F16F1/373

CPC分类号： B60G15/067 ,  B60G13/003 ,  B60G15/063 ,  B60G15/068 ,  B60G2204/128 ,  B60G2204/41 ,  F16F1/3732 ,  F16F1/3735 ,  F16F9/54

摘要： A damper mounting structure is provided with a top buffer member and a bottom buffer member. The bottom buffer member has a protruding section that protrudes with an outer diameter smaller than the outer diameter of the bottom buffer member. The damper mounting structure mates with the protruding section and is anchored to a vehicle body panel, and is provided with a collar formed at substantially the same height as the height of the protruding section. The corner of an opening formed on the vehicle body panel, which comes into contact with the top buffer member, is chamfered.

摘要翻译： 阻尼器安装结构设置有顶部缓冲构件和底部缓冲构件。 底部缓冲构件具有突出部，突出部的外径小于底部缓冲部件的外径。 阻尼器安装结构与突出部分配合并且被锚固到车体面板上，并且设置有与突出部分的高度基本相同的高度形成的套环。 与顶部缓冲构件接触的车身面板上形成的开口的角部被倒角。

公开(公告)号：US20130069393A1

公开(公告)日：2013-03-21

申请号：US13699399

申请日：2011-04-22

申请人： Makoto Kihara ,  Shuji Ichikawa ,  Daisuke Naoi

发明人： Makoto Kihara ,  Shuji Ichikawa ,  Daisuke Naoi

IPC分类号： B62D25/08

CPC分类号： B62D25/08 ,  B62D21/152 ,  B62D25/082 ,  B62D25/14 ,  B62D25/2018

摘要： A structure for a vehicle body front portion, provided with a cross-member (24) which is provided to a dashboard lower panel (19) on the engine room (13) side thereof and is extended between left and right front side frames (16, 16). The cross-member (24) is divided into left and right cross-members (65, 66). A cup-shaped joint cover (22) is sandwiched between the left and right cross-members (65, 66).

摘要翻译： 一种用于车体前部的结构，设置有横向构件（24），其设置在其发动机室（13）侧的仪表板下面板（19）上并且在左右前侧框架（16）之间延伸 ，16）。 横向构件（24）被分成左右横向构件（65,66）。 杯形接头盖（22）夹在左右横梁（65,66）之间。

公开(公告)号：US20100093658A1

公开(公告)日：2010-04-15

申请号：US12160162

申请日：2006-12-28

申请人： Makoto Kihara ,  Shigeki Araki ,  Chikako Shimizu ,  Yoshiyuki Nakamura ,  Kazutoshi Ito ,  Sachie Ikegami ,  Seiichiro Aoe

发明人： Makoto Kihara ,  Shigeki Araki ,  Chikako Shimizu ,  Yoshiyuki Nakamura ,  Kazutoshi Ito ,  Sachie Ikegami ,  Seiichiro Aoe

IPC分类号： A61K31/715 ,  A61P3/00

CPC分类号： A61K36/899 ,  A23L33/22 ,  A23L33/26 ,  A23V2002/00 ,  A61K31/716 ,  A23V2200/326 ,  A23V2200/3202 ,  A23V2250/5034

摘要： It is an object of the invention to provide a novel therapeutic agent that can reduce visceral fat accumulation to prevent or treat metabolic syndrome. In order to achieve this object, the invention provides a therapeutic agent for metabolic syndrome that comprises, as an active ingredient, dietary fiber aggregation in which water-soluble β-glucan has the highest content. Particularly effective as the water-soluble β-glucan is water-soluble β-glucan having a β-1,3 glycoside bond and β-1,4 glycoside bond in the same molecule.

摘要翻译： 本发明的目的是提供一种可以减少内脏脂肪积累以预防或治疗代谢综合征的新型治疗剂。 为了达到上述目的，本发明提供一种代谢综合征治疗剂，其特征在于，作为活性成分，含有水溶性葡聚糖含量最高的膳食纤维聚集体。 特别有效，因为水溶性葡聚糖是在同一分子中具有＆bgr; -1,3糖苷键和＆bgr-1,4糖苷键的水溶性葡萄糖。