Preparation of angelic acid or esters thereof
    2.
    发明授权
    Preparation of angelic acid or esters thereof 失效
    制备当归酸或其酯

    公开(公告)号:US4613680A

    公开(公告)日:1986-09-23

    申请号:US589075

    申请日:1984-02-24

    摘要: Angelic acid or esters thereof which are useful as perfume materials are prepared by isomerizing tiglic acid or an ester thereof with an organic sulfinic acid as the catalyst, and novel esters of angelic acid represented by the formula ##STR1## wherein R represents 3-hexenyl, 3-methyl-2-butenyl, 3-methyl-3-butenyl, 3-methyl-2-pentenyl, 3-methyl-4-pentenyl, CH.sub.3 (CH.sub.2).sub.l - (in which l is an integer from 5 to 9), cyclopentyl, cyclohexyl, 2-methylpentyl, .alpha.-methylbenzyl, neryl or furfuryl are provided as part of said esters of angelic acid.

    摘要翻译: PCT No.PCT / JP82 / 00248 Sec。 1984日期1984年2月24日 102(e)日期1984年2月24日PCT Filed 1982年6月28日PCT公布。 公开号WO84 / 00161 1984年1月19日。用作香料的苯丙酸或其酯是通过用有机亚磺酸作为催化剂使叔丁基酸或其酯异构化制备的,并且由式 其中R表示3-己烯基,3-甲基-2-丁烯基,3-甲基-3-丁烯基,3-甲基-2-戊烯基,3-甲基-4-戊烯基,CH 3(CH 2)1 - (其中l是 5至9的整数),环戊基,环己基,2-甲基戊基,α-甲基苄基,橙花基或糠基作为所述的当归酸的一部分提供。

    Therapeutic agent for treating wounds using monocyte chemotactic and
activating factor
    4.
    发明授权
    Therapeutic agent for treating wounds using monocyte chemotactic and activating factor 失效
    使用单核细胞趋化和激活因子治疗伤口的治疗剂

    公开(公告)号:US5646117A

    公开(公告)日:1997-07-08

    申请号:US433519

    申请日:1995-07-12

    CPC分类号: C07K14/523 A61K38/00

    摘要: A therapeutic agent for treating wounds having properties and actions different from those of growth factors and proteins inducing growth factors, which have strong therapeutic effect is disclosed. The therapeutic agent for treating wounds according to the present invention comprises monocyte chemotactic and activating factor or a variation thereof having a monocyte-attracting property or a derivative of said monocyte chemotactic and activating factor or said variation thereof.

    摘要翻译: PCT No.PCT / JP94 / 01512 Sec。 371日期:1995年7月12日 102(e)日期1995年7月12日PCT 1994年9月13日PCT PCT。 公开号WO95 / 07710 日期:1995年3月23日公开了具有强效治疗作用的具有不同于生长因子和诱导生长因子的蛋白质的性质和作用的伤口的治疗剂。 根据本发明的治疗伤口的治疗剂包含单核细胞趋化性和活化因子或其单核细胞吸引性的变体或所述单核细胞趋化性和激活因子的衍生物或其变化。

    Method promoting conception by administering IL-8 or MCAF
    6.
    发明授权
    Method promoting conception by administering IL-8 or MCAF 失效
    通过施用IL-8或MCAF促进受孕的方法

    公开(公告)号:US6013252A

    公开(公告)日:2000-01-11

    申请号:US817941

    申请日:1997-06-05

    摘要: Leukocyte chemotactic factors such as interleukin-8 and MCAF, and inductive substances therefor were revealed to have proconceptive activities. These activities include promoting ovum growth and fertilized ovum implantation, and are exhibited by a sole substance. Accordingly, it has been shown that such substances can be used in drugs concerning medical treatment for infertility, and further, can be used in veterinary and livestock industry fields such as reproduction of industrial animals or species preservation of rare animals.

    摘要翻译: PCT No.PCT / JP96 / 02412 Sec。 371日期:1997年6月5日 102(e)日期1996年6月5日PCT 1996年8月28日PCT公布。 出版物WO97 / 07813 日期1997年3月6日白细胞趋化因子如白细胞介素-8和MCAF及其诱导物质显示具有反潜活性。 这些活动包括促进卵子生长和受精卵子植入,并由单一物质展示。 因此,已经表明,这些物质可以用于不育医疗的药物中,并且还可以用于兽医和畜牧业领域,例如工业动物的繁殖或稀有动物的物种保存。

    Serine protease and serine protease gene
    7.
    发明授权
    Serine protease and serine protease gene 失效
    丝氨酸蛋白酶和丝氨酸蛋白酶基因

    公开(公告)号:US5661000A

    公开(公告)日:1997-08-26

    申请号:US385230

    申请日:1995-02-08

    CPC分类号: C12N9/6424

    摘要: The present invention offers the serine protease exhibiting a biological activity which a polypeptide having an amino acid sequence shown in FIG. 1 shows, the serine protease precursor where a cleavable peptide or signal peptide connects with the N-terminal of the said serine protease, and the gene encoding them. The serine protease being useful in medical treatment fields can be manufactured in large quantities by the present invention.Moreover, the present invention offers the DNA sequence coding a transcription controlling region contained in the chromosomal gene of the serine protease of a human myeloid cell. This sequence is the transcription controlling region being necessary for the gene expression being specific to a human leukocyte or erythrocyte.

    摘要翻译: 本发明提供具有生物活性的丝氨酸蛋白酶,其具有图1所示的氨基酸序列。 图1显示丝氨酸蛋白酶前体,其中可切割肽或信号肽与所述丝氨酸蛋白酶的N末端连接,以及编码它们的基因。 可用于医疗领域的丝氨酸蛋白酶可以通过本发明大量制造。 此外,本发明提供了编码人骨髓细胞的丝氨酸蛋白酶的染色体基因中包含的转录控制区的DNA序列。 该序列是对人白细胞或红细胞特异性的基因表达所必需的转录控制区。