-
公开(公告)号：US08324232B2
公开(公告)日：2012-12-04
申请号：US12673413
申请日：2008-08-15
申请人： Martin Bolli , Christoph Boss , Alexander Treiber
发明人： Martin Bolli , Christoph Boss , Alexander Treiber
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D403/12
摘要： The invention relates to the compound of structural formula (I) and the salts thereof. Said compound is useful as endothelin receptor antagonist. The invention further relates to a process for preparing said compound.
摘要翻译： 本发明涉及结构式（I）的化合物及其盐。 所述化合物可用作内皮素受体拮抗剂。 本发明还涉及制备所述化合物的方法。
-
公开(公告)号：US20120142716A1
公开(公告)日：2012-06-07
申请号：US12673413
申请日：2008-08-15
申请人： Martin Bolli , Christoph Boss , Alexander Treiber
发明人： Martin Bolli , Christoph Boss , Alexander Treiber
IPC分类号： A61K31/506 , A61P9/12 , A61P9/00 , A61P9/10 , A61P13/12 , A61P25/28 , A61P25/06 , A61P7/04 , A61P1/04 , A61P29/00 , A61P35/00 , A61P13/08 , A61P15/10 , A61P27/16 , A61P11/08 , A61P11/06 , A61P11/00 , A61P31/00 , A61P7/06 , A61P27/06 , A61P19/04 , A61P3/10 , A61P37/06 , A61P3/06 , A61P9/04 , A61P25/00 , C07D403/12
CPC分类号： C07D403/12
摘要： The invention relates to the compound of structural formula (I) and the salts thereof. Said compound is useful as endothelin receptor antagonist. The invention further relates to a process for preparing said compound.
摘要翻译： 本发明涉及结构式（I）的化合物及其盐。 所述化合物可用作内皮素受体拮抗剂。 本发明还涉及制备所述化合物的方法。
-
23.发明授权公开(公告)号：US08912340B2
公开(公告)日：2014-12-16
申请号：US13565469
申请日：2012-08-02
申请人： Stefan Abele , Martin Bolli , Gunther Schmidt
发明人： Stefan Abele , Martin Bolli , Gunther Schmidt
IPC分类号： C07D277/54
CPC分类号： C07D277/54
摘要： The present invention relates to a new process for the preparation of 2-imino-thiazolidin-4-one compounds of the Formula (I) and (II) and to compounds of Formula (II) as such. The present compounds of Formula (II) can be used as intermediates in the preparation of thiazolidin-4-one derivatives of the General Formula (II), said derivatives being described in WO 2005/054215. These compounds of General Formula (II) are described in WO 2005/054215 to act as immunosuppressive agents.
摘要翻译： 本发明涉及制备式（I）和（II）的2-亚氨基 - 噻唑烷-4-酮化合物和式（II）化合物的新方法。 本发明的式（II）化合物可用作制备通式（II）的噻唑烷-4-酮衍生物的中间体，所述衍生物描述于WO 2005/054215中。 这些通式（II）化合物描述于WO 2005/054215中，用作免疫抑制剂。
-
公开(公告)号：US20130303514A1
公开(公告)日：2013-11-14
申请号：US13980764
申请日：2012-01-18
申请人： Martin Bolli , Cyrille Lescop , Boris Mathys , Keith Morrison , Claus Mueller , Oliver Nayler , Beat Steiner
发明人： Martin Bolli , Cyrille Lescop , Boris Mathys , Keith Morrison , Claus Mueller , Oliver Nayler , Beat Steiner
IPC分类号： C07D413/14 , C07D413/04
CPC分类号： C07D413/14 , C07D413/04
摘要： The invention relates to pyridine derivatives of Formula (I) wherein A, R1, R2, R3, and R4 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.
摘要翻译： 本发明涉及式（I）的吡啶衍生物，其中A，R 1，R 2，R 3和R 4如说明书中所述，其制备及其作为药物活性化合物的用途。 所述化合物特别充当免疫调节剂。
-
公开(公告)号：US08410151B2
公开(公告)日：2013-04-02
申请号：US12920574
申请日：2009-03-03
申请人： Martin Bolli , Cyrille Lescop , Boris Mathys , Claus Mueller , Oliver Nayler , Beat Steiner
发明人： Martin Bolli , Cyrille Lescop , Boris Mathys , Claus Mueller , Oliver Nayler , Beat Steiner
IPC分类号： A61K31/4245 , C07D271/06
CPC分类号： C07D271/06
摘要： The invention relates to novel aminomethyl benzene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.
摘要翻译： 本发明涉及新型氨基甲基苯衍生物，其制备及其作为药物活性化合物的用途。 所述化合物特别充当免疫调节剂。
-
公开(公告)号：US08273779B2
公开(公告)日：2012-09-25
申请号：US12496945
申请日：2009-07-02
申请人： Christoph Binkert , Martin Bolli , Boris Mathys , Claus Mueller , Michael Scherz , Oliver Nayler
发明人： Christoph Binkert , Martin Bolli , Boris Mathys , Claus Mueller , Michael Scherz , Oliver Nayler
IPC分类号： A61K31/41 , A01N43/82 , C07D277/00 , C07D327/04 , C07D343/00
CPC分类号： C07D277/54 , A61K31/426 , C07D277/20 , C07D277/42 , C07D417/06
摘要： The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.
摘要翻译： 本发明涉及含有至少一种噻唑烷-4-酮衍生物以预防或治疗与活化的免疫系统相关的疾病的药物组合物。 此外，本发明涉及特别用作药物活性化合物的新型噻唑烷-4-酮衍生物。 所述化合物还特别用作免疫抑制剂。
-
公开(公告)号：US20120195930A1
公开(公告)日：2012-08-02
申请号：US13438657
申请日：2012-04-03
申请人： Martin Bolli , David Lehmann , Boris Mathys , Claus Mueller , Oliver Nayler , Beat Steiner , Jörg Velker
发明人： Martin Bolli , David Lehmann , Boris Mathys , Claus Mueller , Oliver Nayler , Beat Steiner , Jörg Velker
IPC分类号： A61K31/4439 , A61P37/06 , A61P25/00 , A61P17/00 , A61P17/06 , A61P1/00 , A61P29/00 , C07D413/14 , A61P19/02
CPC分类号： C07D409/06 , C07D413/14
摘要： The invention relates to novel pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.
摘要翻译： 本发明涉及新颖的吡啶衍生物，其制备及其作为药物活性化合物的用途。 所述化合物特别充当免疫抑制剂。
-
公开(公告)号：US20110028448A1
公开(公告)日：2011-02-03
申请号：US12920569
申请日：2009-03-03
申请人： Martin Bolli , Cyrille Lescop , Boris Mathys , Claus Mueller , Oliver Nayler , Beat Steiner
发明人： Martin Bolli , Cyrille Lescop , Boris Mathys , Claus Mueller , Oliver Nayler , Beat Steiner
IPC分类号： A61K31/4439 , C07D413/04 , C07D413/14 , A61P11/06 , A61P29/00 , A61P17/06 , A61P25/00 , A61P3/10 , A61P35/00 , A61P35/04
CPC分类号： C07D413/04
摘要： The invention relates to pyridine compounds, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.
摘要翻译： 本发明涉及吡啶化合物，其制备及其作为药物活性化合物的用途。 所述化合物特别充当免疫调节剂。
-
29.发明申请NEW PROCESS FOR THE PREPARATION OF 2-IMINO-THIAZOLIDIN-4-ONE DERIVATIVES 有权制备2-IMINO-THIAZOLIDIN-4-ONE衍生物的新工艺公开(公告)号：US20100317867A1
公开(公告)日：2010-12-16
申请号：US12516055
申请日：2007-11-22
申请人： Stefan Abele , Martin Bolli , Gunther Schmidt
发明人： Stefan Abele , Martin Bolli , Gunther Schmidt
IPC分类号： C07D277/54
CPC分类号： C07D277/54
摘要： The present invention relates to a new process for the preparation of 2-imino-thiazolidin-4-one compounds of the Formula (I) and (II) and to compounds of Formula (II) as such. The present compounds of Formula (II) can be used as intermediates in the preparation of thiazolidin-4-one derivatives of the General Formula (II), said derivatives being described in WO 2005/054215. These compounds of General Formula (II) are described in WO 2005/054215 to act as immunosuppressive agents.
摘要翻译： 本发明涉及制备式（I）和（II）的2-亚氨基 - 噻唑烷-4-酮化合物和式（II）化合物的新方法。 本发明的式（II）化合物可用作制备通式（II）的噻唑烷-4-酮衍生物的中间体，所述衍生物描述于WO 2005/054215中。 这些通式（II）化合物描述于WO 2005/054215中，用作免疫抑制剂。
-
公开(公告)号：USRE43728E1
公开(公告)日：2012-10-09
申请号：US13194172
申请日：2004-11-16
申请人： Christoph Binkert , Martin Bolli , Boris Mathys , Claus Mueller , Michael Scherz , Oliver Nayler
发明人： Christoph Binkert , Martin Bolli , Boris Mathys , Claus Mueller , Michael Scherz , Oliver Nayler
IPC分类号： A61K31/426 , C07D277/54
CPC分类号： C07D277/54 , A61K31/426 , C07D277/20 , C07D277/42 , C07D417/06
摘要： The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.
摘要翻译： 本发明涉及含有至少一种噻唑烷-4-酮衍生物以预防或治疗与活化的免疫系统相关的疾病的药物组合物。 此外，本发明涉及特别用作药物活性化合物的新型噻唑烷-4-酮衍生物。 所述化合物还特别用作免疫抑制剂。
-
-
-
-
-
-
-
-
-
搜索结果
82 条记录 (耗时 0.036 秒)
