公开(公告)号：US20130102644A1

公开(公告)日：2013-04-25

申请号：US13805151

申请日：2011-06-27

申请人： Masatoshi Hagiwara ,  Masafumi Matsuo ,  Naoyuki Kataoka ,  Atsushi Nishida

发明人： Masatoshi Hagiwara ,  Masafumi Matsuo ,  Naoyuki Kataoka ,  Atsushi Nishida

IPC分类号： A61K31/428

CPC分类号： A61K31/428 ,  C07D277/64 ,  C07K14/4707 ,  C07K14/4708 ,  C12N9/12

摘要： An object of the present invention is to provide a prophylactic or ameliorating agent for a genetic disease that is caused by a mutation in an exon of a gene and is capable of forming a functional truncated protein by skipping of the exon comprising the mutation. The prophylactic or ameliorating agent used in the present invention is a prophylactic or ameliorating agent for a genetic disease that is caused by a mutation in an exon of a gene and is capable of forming a functional truncated protein by skipping of the exon comprising the mutation, wherein the prophylactic or ameliorating agent contains a compound having a molecular weight of 1500 or lower.

摘要翻译： 本发明的目的是提供由基因外显子突变引起的遗传疾病的预防或改善剂，并且能够通过跳过包含突变的外显子形成功能性截短的蛋白质。 用于本发明的预防或改善剂是由基因外显子突变引起的遗传疾病的预防或改善剂，能够通过跳过包含突变的外显子形成功能性截短蛋白， 其中所述预防或改善剂含有分子量为1500以下的化合物。

公开(公告)号：US07569536B2

公开(公告)日：2009-08-04

申请号：US10584482

申请日：2004-12-24

申请人： Masatoshi Hagiwara ,  Takeshi Fukuhara ,  Masaaki Suzuki ,  Takamitsu Hosoya

发明人： Masatoshi Hagiwara ,  Takeshi Fukuhara ,  Masaaki Suzuki ,  Takamitsu Hosoya

IPC分类号： A01N61/00 ,  A61K51/00 ,  C12N15/09 ,  C12N9/12

CPC分类号： A61K31/444 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/4453 ,  A61K31/4545 ,  A61K31/455 ,  A61K31/5377 ,  A61K31/55 ,  C07D211/14 ,  C07D213/81 ,  C07D213/82 ,  C07D401/12 ,  C12N15/1137 ,  Y02A50/385 ,  Y02A50/389 ,  Y02A50/463 ,  Y02A50/465 ,  Y02A50/467

摘要： The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation of SR proteins, and (ii) antiviral agents that act by inhibiting proteins that phosphorylate SR proteins; (2) antiviral agents that act by inhibiting the expression of SR proteins, and (3) antiviral agents that act by activating proteins that antagonize SR proteins. The present invention also provides compounds that inhibit SRPKs, which phosphorylate SR proteins. Such compounds inhibit the activity of SR proteins and have antiviral activities. Various new viruses including SARS have emerged, and thus the present invention provides long-lasting broad-spectrum antiviral agents applicable to new viruses.

摘要翻译： 本发明提供：（1）通过降低或抑制SR蛋白的活性而起作用的抗病毒剂，更具体地，（i）通过增强SR蛋白的去磷酸化作用的抗病毒剂，和（ii）通过抑制蛋白质起作用的抗病毒剂 磷酸化SR蛋白; （2）通过抑制SR蛋白的表达起作用的抗病毒剂，和（3）通过激活拮抗SR蛋白的蛋白质起作用的抗病毒剂。 本发明还提供抑制磷酸化SR蛋白的SRPK的化合物。 这些化合物抑制SR蛋白的活性并具有抗病毒活性。 出现了包括SARS在内的各种新病毒，因此本发明提供了适用于新病毒的长效广谱抗病毒剂。

公开(公告)号：US5216150A

公开(公告)日：1993-06-01

申请号：US758808

申请日：1991-09-12

申请人： Hiroyoshi Hidaka ,  Tomohiko Ishikawa ,  Masatoshi Hagiwara ,  Tsutomu Inoue ,  Kenji Naitoh ,  Osamu Sakuma ,  Masayuki Yuasa ,  Tadashi Morita ,  Tadashi Toshioka ,  Isao Umezawa ,  Takashi Inaba

发明人： Hiroyoshi Hidaka ,  Tomohiko Ishikawa ,  Masatoshi Hagiwara ,  Tsutomu Inoue ,  Kenji Naitoh ,  Osamu Sakuma ,  Masayuki Yuasa ,  Tadashi Morita ,  Tadashi Toshioka ,  Isao Umezawa ,  Takashi Inaba

IPC分类号： C07C311/16 ,  C07D217/02 ,  C07D217/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D491/10

CPC分类号： C07D401/12 ,  C07C311/16 ,  C07D217/02 ,  C07D217/10 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D491/10

摘要： Novel quinoline sulfonamino derivatives having a vessel smooth muscle relaxation activity as well as a platelet agglutination inhibitory activity and inhibitory activity to protein kinase A, myosin light chain kinase, proteinkinase C, and calmodulindependent proteinkinase II, but having little action or cardio function; a process for the production of the derivatives, and a pharmaceutical composition containing the derivative.

摘要翻译： 具有血管平滑肌松弛活性的新型喹啉磺氨基衍生物以及血小板凝集抑制活性和对蛋白激酶A，肌球蛋白轻链激酶，蛋白激酶C和钙调蛋白依赖性蛋白激酶II的抑制活性，但几乎没有作用或心脏功能; 制备衍生物的方法和含有该衍生物的药物组合物。