公开(公告)号：US20180071530A1

公开(公告)日：2018-03-15

申请号：US15699873

申请日：2017-09-08

Applicant: MEDTRONIC, INC.

Inventor： Jonathon E. Giftakis ,  Timothy J. Denison ,  Paul H. Stypulkowski ,  Scott R. Stanslaski ,  Robert S. Raike ,  Mae Eng ,  David E. Linde ,  Thomas Adamski

IPC: A61N1/36 ,  A61N1/05

CPC classification number: A61N1/3614 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/36082 ,  A61N1/36142 ,  A61N1/36185 ,  A61N2001/083

Abstract: In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity.

公开(公告)号：US20150202447A1

公开(公告)日：2015-07-23

申请号：US14599126

申请日：2015-01-16

Applicant: Medtronic, Inc.

Inventor： Pedram Afshar ,  Timothy J. Denison ,  David E. Linde ,  Scott R. Stanslaski

IPC: A61N1/36 ,  A61B5/00 ,  A61B5/04 ,  G06F19/00 ,  A61B5/0478

CPC classification number: A61N1/36139 ,  A61B5/04012 ,  A61B5/0478 ,  A61B5/4082 ,  A61B5/4836 ,  A61B5/686 ,  A61N1/0534 ,  A61N1/3606 ,  A61N1/36067 ,  A61N1/36171 ,  G06F19/00 ,  G06F19/3481 ,  G16H20/40

Abstract: The disclosure describes a method and system or controlling symptoms of patients suffering from Parkinson's Disease. In some examples, one or more biomarkers indicative of a patient's present symptoms are determined. The biomarkers may be used to control therapy delivered to the patient in a closed-loop manner. In addition, biomarkers may be used as an indication of therapy effectiveness.

Abstract translation: 本公开描述了患有帕金森病的患者的方法和系统或控制症状。 在一些实例中，确定指示患者目前症状的一种或多种生物标志物。 生物标志物可用于控制以闭环方式递送给患者的治疗。 此外，生物标志物可用作治疗有效性的指标。

公开(公告)号：US20140276186A1

公开(公告)日：2014-09-18

申请号：US13862238

申请日：2013-04-12

Applicant: MEDTRONIC, INC.

Inventor： Scott R. Stanslaski ,  David L. Carlson ,  Peng Cong ,  Timothy J. Denison ,  David E. Linde ,  Randy M. Jensen

IPC: A61B5/00 ,  A61B5/048

CPC classification number: A61B5/7225 ,  A61B5/04004 ,  A61B5/04012 ,  A61B5/0428 ,  A61B5/048 ,  A61B5/0496 ,  A61B5/7217 ,  A61N1/36125 ,  A61N1/3702 ,  A61N1/3704 ,  H03F3/38 ,  H03F2200/261

Abstract: This disclosure describes techniques for controlling spectral aggressors in a sensing device that uses a chopper amplifier to amplify an input signal prior to sampling the signal. In some examples, the techniques for controlling spectral aggressors may include generating a chopper-stabilized amplified version of an input signal based on a chopper frequency, sampling the chopper-stabilized amplified version of the input signal at a sampling rate to generate a sampled signal, and analyzing a target frequency band of the sampled signal. The chopper frequency and the sampling rate may cause spectral interference that is generated due to the chopper frequency to occur in the sampled signal at one or more frequencies that are outside of the target frequency band of the sampled signal. The techniques for controlling spectral aggressors may reduce the noise caused by the chopper frequency in the resulting sampled signal, thereby improving the quality of the signal.

Abstract translation: 本公开描述了用于控制感测装置中的光谱侵略者的技术，其在采样信号之前使用斩波放大器放大输入信号。 在一些示例中，用于控制频谱侵略者的技术可以包括基于斩波频率产生输入信号的斩波稳定放大版本，以采样率对输入信号的斩波稳定放大版本进行采样以产生采样信号， 并分析采样信号的目标频带。 斩波频率和采样率可能导致由于斩波频率在采样信号中在采样信号的目标频带之外的一个或多个频率处发生的频谱干扰。 用于控制频谱侵入者的技术可以减少由所得到的采样信号中的斩波频率引起的噪声，从而提高信号的质量。