摘要:
The present invention relates to novel piperazine-piperidine compounds. The compounds are useful as 5-HT1A binding agents, particularly as 5-HT1A receptor antagonists and agonists. These compounds are useful in treating central nervous system disorders, such as cognition disorders, anxiety disorders, depression and sexual dysfunction.
摘要:
A compound of formula (I) ##STR1## wherein: X=N and Y=CH or X=CH and Y=NR.sub.1 and R.sub.2 are independently, straight chain alkyl of 2 to 12 carbon atoms, branched chain alkyl of 3 to 10 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, aryl of 4 to 10 carbon atoms, 4 to 10 membered heteroaryl or a moiety of the formula (CH.sub.2).sub.m -A wherein m is 1 to 9 and A is cycloalkyl of 3 to 7 carbon atoms; and R.sub.3 is a straight chain alkyl of 1 to 12 carbon atoms, branched chain alkyl of 3 to 10 carbon atoms, aryl of 4 to 10 carbon atoms or 4 to 10 membered heteroaryl for use in the treatment of disorders associated with bone loss by increased transcription and elevation of plasma calcitonin levels.
摘要翻译:式(I)的化合物,其中:X = N,Y = CH或X = CH,Y = N R 1,R 2独立地为2至12个碳原子的直链烷基,3至10个碳原子的支链烷基, 3至10个碳原子的环烷基,4至10个碳原子的芳基,4至10元杂芳基或式(CH2)mA部分,其中m为1至9,A为3至7个碳原子的环烷基; 并且R 3是1至12个碳原子的直链烷基,3至10个碳原子的支链烷基,4至10个碳原子的芳基或4至10元杂芳基,用于治疗与骨丢失相关的疾病增加 血浆降钙素水平的转录和升高。
摘要:
The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of a CNS disorder related to or affected by the 5-HT6 receptor.
摘要:
The present teachings provide compounds of formula I and their pharmaceutically acceptable salts, hydrates, and esters, wherein R1, R2, and X are as defined herein. The present teachings also provide methods of making the compounds of formula I, and methods of treating autoimmune and inflammatory diseases by administering a therapeutically effective amount of a compound or compounds of formula I to a mammal including a human.
摘要:
The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of a CNS disorder related to or affected by the 5-HT6 receptor
摘要:
The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of a CNS disorder related to or affected by the 5-HT6 receptor.