Pyrazolopyrimidine-2,4-dione sulfonamides
    22.
    发明授权
    Pyrazolopyrimidine-2,4-dione sulfonamides 失效
    吡唑并嘧啶-2,4-二酮磺酰胺

    公开(公告)号:US6133273A

    公开(公告)日:2000-10-17

    申请号:US304180

    申请日:1999-05-03

    CPC分类号: C07D487/04 A61K31/519

    摘要: A compound of formula (I) ##STR1## wherein: X=N and Y=CH or X=CH and Y=NR.sub.1 and R.sub.2 are independently, straight chain alkyl of 2 to 12 carbon atoms, branched chain alkyl of 3 to 10 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, aryl of 4 to 10 carbon atoms, 4 to 10 membered heteroaryl or a moiety of the formula (CH.sub.2).sub.m -A wherein m is 1 to 9 and A is cycloalkyl of 3 to 7 carbon atoms; and R.sub.3 is a straight chain alkyl of 1 to 12 carbon atoms, branched chain alkyl of 3 to 10 carbon atoms, aryl of 4 to 10 carbon atoms or 4 to 10 membered heteroaryl for use in the treatment of disorders associated with bone loss by increased transcription and elevation of plasma calcitonin levels.

    摘要翻译: 式(I)的化合物,其中:X = N,Y = CH或X = CH,Y = N R 1,R 2独立地为2至12个碳原子的直链烷基,3至10个碳原子的支链烷基, 3至10个碳原子的环烷基,4至10个碳原子的芳基,4至10元杂芳基或式(CH2)mA部分,其中m为1至9,A为3至7个碳原子的环烷基; 并且R 3是1至12个碳原子的直链烷基,3至10个碳原子的支链烷基,4至10个碳原子的芳基或4至10元杂芳基,用于治疗与骨丢失相关的疾病增加 血浆降钙素水平的转录和升高。