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公开(公告)号:US20070270587A1
公开(公告)日:2007-11-22
申请号:US11772549
申请日:2007-07-02
申请人: Paul Dollings , Arlene Dietrich , Lisa Havran , Chae-Koo Chong , Donna Huryn , Albert Robichaud , Boyd Harrison , Wayne Childers , Alexander Greenfield , James Bicksler , Vasilios Marathias
发明人: Paul Dollings , Arlene Dietrich , Lisa Havran , Chae-Koo Chong , Donna Huryn , Albert Robichaud , Boyd Harrison , Wayne Childers , Alexander Greenfield , James Bicksler , Vasilios Marathias
IPC分类号: C07D239/70
CPC分类号: C07D487/04 , C07D487/10
摘要: Novel pyrimidoindolone compounds are disclosed. Methods of using the pyrimidoindolone compounds and compositions containing the compounds in the treatment and/or prevention of disease and other conditions related to inflammation, neurodegeneration, osteoarthritis and apoptosis are also disclosed.
摘要翻译: 公开了新的嘧啶吲哚酮化合物。 还公开了使用嘧啶吲哚酮酮化合物和含有该化合物的组合物在治疗和/或预防与炎症,神经变性,骨关节炎和细胞凋亡相关的疾病和其它病状的方法。
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公开(公告)号:US09233095B2
公开(公告)日:2016-01-12
申请号:US13981015
申请日:2012-01-26
申请人: Paul M. Dunman , Patrick D. Olson , Wayne Childers
发明人: Paul M. Dunman , Patrick D. Olson , Wayne Childers
IPC分类号: A61K31/402 , C07D207/337 , A61K31/341 , C07D307/68 , C07D307/56 , C07D405/06 , C07D417/06 , A61K31/427 , A61K45/06
CPC分类号: A61K31/427 , A61K31/341 , A61K31/402 , A61K45/06 , C07D207/337 , C07D307/56 , C07D307/68 , C07D405/06 , C07D417/06 , C12Q1/44 , G01N2333/922 , G01N2500/04 , G01N2500/10 , A61K2300/00
摘要: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.
摘要翻译: 本文描述了细菌核糖核酸酶(例如RnpA)的小分子抑制剂及其合成和使用的方法。 使用化合物的方法包括治疗和预防微生物感染和抑制细菌核糖核酸酶。 本文还描述了鉴定用于治疗或预防微生物感染的化合物的方法。
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公开(公告)号:US20130296386A1
公开(公告)日:2013-11-07
申请号:US13981011
申请日:2012-01-26
申请人: Paul M. Dunman , Patrick D. Olson , Wayne Childers
发明人: Paul M. Dunman , Patrick D. Olson , Wayne Childers
IPC分类号: C07D417/06 , A61K31/427 , A61K45/06 , A61K31/341
CPC分类号: A61K31/427 , A61K31/341 , A61K31/402 , A61K45/06 , C07D207/337 , C07D307/56 , C07D307/68 , C07D405/06 , C07D417/06 , C12Q1/44 , G01N2333/922 , G01N2500/04 , G01N2500/10 , A61K2300/00
摘要: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease.
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公开(公告)号:US20110049733A1
公开(公告)日:2011-03-03
申请号:US12861068
申请日:2010-08-23
IPC分类号: B01F3/04
摘要: A water cooling tower having an improved water collection system. The cooling tower has an outer shell, legs, and one or more layers of fill material, through which the water to be cooled moves vertically downward. The water is distributed across the upper surface of the fill material by piping and nozzles. A fan underlying the fill material moves air vertically upward through the fill material. The water collection system, which is positioned below the fill material, has upper and lower troughs which receive water flowing vertically downward through the fill material. Preferably, the lower troughs are positioned beneath the spaces between upper troughs, to catch water falling between the upper troughs. A number of hinged baffles close off the spaces between lower troughs, but rotate upward in response to upward air flow and open the spaces between the lower troughs.
摘要翻译: 具有改进的采水系统的水冷却塔。 冷却塔具有外壳,脚和一层或多层填充材料,待冷却的水通过该填充材料垂直向下移动。 水通过管道和喷嘴分布在填充材料的上表面上。 填充材料下面的风扇将空气垂直向上移动穿过填充材料。 位于填充材料下方的集水系统具有上下槽,其接收垂直向下流过填充材料的水。 优选地,下槽位于上槽之间的空间下方,以捕获落在上槽之间的水。 多个铰链挡板关闭下槽之间的空间,但是响应于向上的气流而向上旋转并打开下槽之间的空间。
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公开(公告)号:US20060223824A1
公开(公告)日:2006-10-05
申请号:US11330907
申请日:2006-01-11
IPC分类号: A61K31/496
CPC分类号: A61K31/496
摘要: Novel piperazine derivatives are provided having the formula wherein R1 is cyano, nitro, trifluoromethyl or halogen, or pharmaceutically acceptable acid addition salts thereof, which are useful as 5-HT1A receptor antagonists.
摘要翻译: 提供具有下式的新型哌嗪衍生物其中R 1是氰基,硝基,三氟甲基或卤素,或其药学上可接受的酸加成盐,其可用作5-HT 1A 受体拮抗剂。
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公开(公告)号:US20050202412A1
公开(公告)日:2005-09-15
申请号:US11104190
申请日:2005-04-12
IPC分类号: A61P13/02 , A61P25/00 , A61P25/18 , A61P25/32 , C07D295/125 , A61K31/495 , C12Q1/00
CPC分类号: C07D295/125 , C07B2200/05 , C07C2601/14
摘要: Compounds of the formula have a long duration of action and are useful for the treatment of chronic diseases resulting from the dysfunction of the serotonergic 5-HT1A system, such as schizophrenia and other psychotic disorders such as paranoia and mano-depressive illness.
摘要翻译: 式的化合物具有较长的作用时间,可用于治疗由5-羟色胺能5-HT 1A系统的功能障碍引起的慢性疾病,例如精神分裂症和其他精神病性疾病如偏执狂和 躁狂抑郁症
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公开(公告)号:US08585024B2
公开(公告)日:2013-11-19
申请号:US12861068
申请日:2010-08-23
IPC分类号: B01F3/04
摘要: A water cooling tower having an improved water collection system. The cooling tower has an outer shell, legs, and one or more layers of fill material, through which the water to be cooled moves vertically downward. The water is distributed across the upper surface of the fill material by piping and nozzles. A fan underlying the fill material moves air vertically upward through the fill material. The water collection system, which is positioned below the fill material, has upper and lower troughs which receive water flowing vertically downward through the fill material. Preferably, the lower troughs are positioned beneath the spaces between upper troughs, to catch water falling between the upper troughs. A number of hinged baffles close off the spaces between lower troughs, but rotate upward in response to upward air flow and open the spaces between the lower troughs.
摘要翻译: 具有改进的采水系统的水冷却塔。 冷却塔具有外壳,脚和一层或多层填充材料,待冷却的水通过该填充材料垂直向下移动。 水通过管道和喷嘴分布在填充材料的上表面上。 填充材料下面的风扇将空气垂直向上移动穿过填充材料。 位于填充材料下方的集水系统具有上下槽,其接收垂直向下流过填充材料的水。 优选地,下槽位于上槽之间的空间下方,以捕获落在上槽之间的水。 多个铰链挡板关闭下槽之间的空间,但是响应于向上的气流而向上旋转并打开下槽之间的空间。
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公开(公告)号:US20130303585A1
公开(公告)日:2013-11-14
申请号:US13981015
申请日:2012-01-26
申请人: Paul M. Dunman , Patrick D. Olson , Wayne Childers
发明人: Paul M. Dunman , Patrick D. Olson , Wayne Childers
IPC分类号: C07D207/337 , A61K45/06 , A61K31/402
CPC分类号: A61K31/427 , A61K31/341 , A61K31/402 , A61K45/06 , C07D207/337 , C07D307/56 , C07D307/68 , C07D405/06 , C07D417/06 , C12Q1/44 , G01N2333/922 , G01N2500/04 , G01N2500/10 , A61K2300/00
摘要: Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.
摘要翻译: 本文描述了细菌核糖核酸酶(例如RnpA)的小分子抑制剂及其合成和使用的方法。 使用化合物的方法包括治疗和预防微生物感染和抑制细菌核糖核酸酶。 本文还描述了鉴定用于治疗或预防微生物感染的化合物的方法。
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公开(公告)号:US20080070925A1
公开(公告)日:2008-03-20
申请号:US11841514
申请日:2007-08-20
申请人: Stacey SUKOFF RIZZO , Sharon ROSENZWEIG-LIPSON , Wayne CHILDERS , Michael KELLY , Lee SCHECHTER
发明人: Stacey SUKOFF RIZZO , Sharon ROSENZWEIG-LIPSON , Wayne CHILDERS , Michael KELLY , Lee SCHECHTER
IPC分类号: A61K31/496 , A61P15/00
CPC分类号: A61K31/137 , A61K31/165 , A61K31/445 , A61K31/496 , A61K31/515 , A61K31/519 , A61K31/5415 , A61K31/55 , A61K31/551
摘要: Methods and compositions are provided for treating sexual dysfunction, e.g., sexual dysfunction associated with drug treatment, using 5-HT1A receptor antagonists.
摘要翻译: 提供了使用5-HT 1A受体拮抗剂治疗性功能障碍(例如与药物治疗相关的性功能障碍)的方法和组合物。
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公开(公告)号:US20060287335A1
公开(公告)日:2006-12-21
申请号:US11396307
申请日:2006-03-30
申请人: Stacey Sukoff Rizzo , Sharon Rosenzweig-Lipson , Wayne Childers , Michael Kelly , Lee Schechter
发明人: Stacey Sukoff Rizzo , Sharon Rosenzweig-Lipson , Wayne Childers , Michael Kelly , Lee Schechter
IPC分类号: A61K31/551 , A61K31/5415 , A61K31/496 , A61K31/55 , A61K31/519 , A61K31/445 , A61K31/515 , A61K31/165 , A61K31/137
CPC分类号: A61K31/137 , A61K31/165 , A61K31/445 , A61K31/496 , A61K31/515 , A61K31/519 , A61K31/5415 , A61K31/55 , A61K31/551
摘要: Methods and compositions are provided for treating sexual dysfunction, e.g., sexual dysfunction associated with drug treatment, using 5-HT1A receptor antagonists.
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