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1.发明申请公开(公告)号：US20070027160A1
公开(公告)日：2007-02-01
申请号：US11450942
申请日：2006-06-09
申请人： Magda Asselin , George Grosu , Annmarie Sabb , Wayne Childers , Lisa Havran , Zhongqi Shen , James Bicksler , Dan Chong
发明人： Magda Asselin , George Grosu , Annmarie Sabb , Wayne Childers , Lisa Havran , Zhongqi Shen , James Bicksler , Dan Chong
IPC分类号： A61K31/496 , C07D403/14
CPC分类号： C07D403/14 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to novel piperazine-piperidine compounds. The compounds are useful as 5-HT1A binding agents, particularly as 5-HT1A receptor antagonists and agonists. These compounds are useful in treating central nervous system disorders, such as cognition disorders, anxiety disorders, depression and sexual dysfunction.
摘要翻译： 本发明涉及新的哌嗪 - 哌啶化合物。 该化合物可用作5-HT 1A结合剂，特别是5-HT 1A受体拮抗剂和激动剂。 这些化合物可用于治疗中枢神经系统疾病，如认知障碍，焦虑障碍，抑郁症和性功能障碍。
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公开(公告)号：US20050250798A1
公开(公告)日：2005-11-10
申请号：US11061144
申请日：2005-02-18
申请人： Paul Dollings , Arlene Dietrich , Lisa Havran , Chae-Koo Chong , Donna Huryn , Albert Robichaud , Boyd Harrison , Wayne Childers , Alexander Greenfield , James Bicksler
发明人： Paul Dollings , Arlene Dietrich , Lisa Havran , Chae-Koo Chong , Donna Huryn , Albert Robichaud , Boyd Harrison , Wayne Childers , Alexander Greenfield , James Bicksler
IPC分类号： A61K31/519 , C07D487/04 , C07D487/10
CPC分类号： C07D487/04 , C07D487/10
摘要： Novel pyrimidoindolone compounds are disclosed. Methods of using the pyrimidoindolone compounds and compositions containing the compounds in the treatment and/or prevention of disease and other conditions related to inflammation, neurodegeneration, osteoarthritis and apoptosis are also disclosed.
摘要翻译： 公开了新的嘧啶吲哚酮化合物。 还公开了使用嘧啶吲哚酮酮化合物和含有该化合物的组合物在治疗和/或预防与炎症，神经变性，骨关节炎和细胞凋亡相关的疾病和其它病状的方法。
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公开(公告)号：US20070270587A1
公开(公告)日：2007-11-22
申请号：US11772549
申请日：2007-07-02
申请人： Paul Dollings , Arlene Dietrich , Lisa Havran , Chae-Koo Chong , Donna Huryn , Albert Robichaud , Boyd Harrison , Wayne Childers , Alexander Greenfield , James Bicksler , Vasilios Marathias
发明人： Paul Dollings , Arlene Dietrich , Lisa Havran , Chae-Koo Chong , Donna Huryn , Albert Robichaud , Boyd Harrison , Wayne Childers , Alexander Greenfield , James Bicksler , Vasilios Marathias
IPC分类号： C07D239/70
CPC分类号： C07D487/04 , C07D487/10
摘要： Novel pyrimidoindolone compounds are disclosed. Methods of using the pyrimidoindolone compounds and compositions containing the compounds in the treatment and/or prevention of disease and other conditions related to inflammation, neurodegeneration, osteoarthritis and apoptosis are also disclosed.
摘要翻译： 公开了新的嘧啶吲哚酮化合物。 还公开了使用嘧啶吲哚酮酮化合物和含有该化合物的组合物在治疗和/或预防与炎症，神经变性，骨关节炎和细胞凋亡相关的疾病和其它病状的方法。
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公开(公告)号：US20060287333A1
公开(公告)日：2006-12-21
申请号：US11506514
申请日：2006-08-18
申请人： Stacey Sukoff Rizzo , Sharon Rosenzweig-Lipson , Wayne Childers , Michael Kelly , Lee Schechter
发明人： Stacey Sukoff Rizzo , Sharon Rosenzweig-Lipson , Wayne Childers , Michael Kelly , Lee Schechter
IPC分类号： A61K31/496
CPC分类号： A61K31/137 , A61K31/165 , A61K31/445 , A61K31/496 , A61K31/515 , A61K31/519 , A61K31/5415 , A61K31/55 , A61K31/551
摘要： Methods and compositions are provided for treating sexual dysfunction, e.g., sexual dysfunction associated with drug treatment, using 5-HT1A receptor antagonists.
摘要翻译： 提供了使用5-HT 1A受体拮抗剂治疗性功能障碍（例如与药物治疗相关的性功能障碍）的方法和组合物。
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公开(公告)号：US09089545B2
公开(公告)日：2015-07-28
申请号：US13981011
申请日：2012-01-26
申请人： Paul M. Dunman , Patrick D. Olson , Wayne Childers
发明人： Paul M. Dunman , Patrick D. Olson , Wayne Childers
IPC分类号： C07D307/68 , A61K31/341 , C07D307/56 , C07D405/06 , C07D417/06 , A61K31/427 , A61K45/06 , A61K31/402 , C07D207/337
CPC分类号： A61K31/427 , A61K31/341 , A61K31/402 , A61K45/06 , C07D207/337 , C07D307/56 , C07D307/68 , C07D405/06 , C07D417/06 , C12Q1/44 , G01N2333/922 , G01N2500/04 , G01N2500/10 , A61K2300/00
摘要： Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease.
摘要翻译： 本文描述了细菌核糖核酸酶（例如RnpA）的小分子抑制剂及其合成和使用的方法。 使用化合物的方法包括治疗和预防微生物感染和抑制细菌核糖核酸酶。
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6.发明申请Bicyclic Indolyl Derivatives and Methods for Their Use as Serotonergic Agents 审中-公开双环吲哚衍生物及其用作血清素能药的方法公开(公告)号：US20070135445A1
公开(公告)日：2007-06-14
申请号：US11623225
申请日：2007-01-15
申请人： Micahel Kelly , Wayne Childers , Boyd Harrison , Gan Zhang , Byron Bravo , Lee Schechter
发明人： Micahel Kelly , Wayne Childers , Boyd Harrison , Gan Zhang , Byron Bravo , Lee Schechter
IPC分类号： A61K31/496 , C07D403/14
CPC分类号： C07D401/12
摘要： Bicyclic indolyl derivatives and compositions containing such compounds are disclosed. Methods of using the bicyclic indolyl derivatives and compositions containing such composition as serotonergic agents, such as in the treatment of depression and anxiety, are also disclosed. In addition, processes for the preparation of bicyclic indolyl derivatives are disclosed.
摘要翻译： 公开了双环吲哚基衍生物和含有这些化合物的组合物。 还公开了使用双环吲哚基衍生物的方法和含有这样的组合物的组合物作为血清素能剂，例如治疗抑郁症和焦虑症的方法。 此外，公开了制备双环吲哚基衍生物的方法。
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7.发明申请Bicyclic derivatives that modulate voltage-gated potassium channels and methods of use thereof 失效调节电压门控钾通道的双环衍生物及其使用方法公开(公告)号：US20060004108A1
公开(公告)日：2006-01-05
申请号：US11151624
申请日：2005-06-13
申请人： Wayne Childers , Jerome Wu , Callain Kim , Edward Podlesny
发明人： Wayne Childers , Jerome Wu , Callain Kim , Edward Podlesny
IPC分类号： A61K31/16 , C07C235/78
CPC分类号： C07C235/82
摘要： Bicyclic amide derivatives of formula (I) or tautomers or pharmaceutically acceptable salts thereof or both are provided: Also provided are processes for preparing the bicyclic amide derivatives as well as pharmaceutical compositions containing the same and therapeutic uses. The bicyclic amide derivatives are useful for treating a variety of conditions associated with the abnormal modulation of one or more Kv1.1 voltage-gated potassium channels.
摘要翻译： 提供式（I）的二环酰胺衍生物或其互变异构体或其药学上可接受的盐或两者：还提供了制备双环酰胺衍生物的方法以及含有其的治疗用途的药物组合物。 双环酰胺衍生物可用于治疗与一种或多种Kv1.1电压门控钾通道的异常调节相关的多种病症。
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8.发明申请Bicyclic indolyl derivatives and methods for their use as serotonergic agents 失效双环吲哚基衍生物及其用作5-羟色胺能药剂的方法公开(公告)号：US20050124630A1
公开(公告)日：2005-06-09
申请号：US10864698
申请日：2004-06-09
申请人： Michael Kelly , Wayne Childers , Boyd Harrison , Gan Zhang , Byron Bravo , Lee Schechter
发明人： Michael Kelly , Wayne Childers , Boyd Harrison , Gan Zhang , Byron Bravo , Lee Schechter
IPC分类号： C07D401/12 , A61K31/496 , C07D43/14
CPC分类号： C07D401/12
摘要： Bicyclic indolyl derivatives and compositions containing such compounds are disclosed. Methods of using the bicyclic indolyl derivatives and compositions containing such composition as serotonergic agents, such as in the treatment of depression and anxiety, are also disclosed. In addition, processes for the preparation of bicyclic indolyl derivatives are disclosed.
摘要翻译： 公开了双环吲哚基衍生物和含有这些化合物的组合物。 还公开了使用双环吲哚基衍生物的方法和含有这样的组合物的组合物作为血清素能剂，例如治疗抑郁症和焦虑症的方法。 此外，公开了制备双环吲哚基衍生物的方法。
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公开(公告)号：US20130303585A1
公开(公告)日：2013-11-14
申请号：US13981015
申请日：2012-01-26
申请人： Paul M. Dunman , Patrick D. Olson , Wayne Childers
发明人： Paul M. Dunman , Patrick D. Olson , Wayne Childers
IPC分类号： C07D207/337 , A61K45/06 , A61K31/402
CPC分类号： A61K31/427 , A61K31/341 , A61K31/402 , A61K45/06 , C07D207/337 , C07D307/56 , C07D307/68 , C07D405/06 , C07D417/06 , C12Q1/44 , G01N2333/922 , G01N2500/04 , G01N2500/10 , A61K2300/00
摘要： Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.
摘要翻译： 本文描述了细菌核糖核酸酶（例如RnpA）的小分子抑制剂及其合成和使用的方法。 使用化合物的方法包括治疗和预防微生物感染和抑制细菌核糖核酸酶。 本文还描述了鉴定用于治疗或预防微生物感染的化合物的方法。
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公开(公告)号：US20060287335A1
公开(公告)日：2006-12-21
申请号：US11396307
申请日：2006-03-30
申请人： Stacey Sukoff Rizzo , Sharon Rosenzweig-Lipson , Wayne Childers , Michael Kelly , Lee Schechter
发明人： Stacey Sukoff Rizzo , Sharon Rosenzweig-Lipson , Wayne Childers , Michael Kelly , Lee Schechter
IPC分类号： A61K31/551 , A61K31/5415 , A61K31/496 , A61K31/55 , A61K31/519 , A61K31/445 , A61K31/515 , A61K31/165 , A61K31/137
CPC分类号： A61K31/137 , A61K31/165 , A61K31/445 , A61K31/496 , A61K31/515 , A61K31/519 , A61K31/5415 , A61K31/55 , A61K31/551
摘要： Methods and compositions are provided for treating sexual dysfunction, e.g., sexual dysfunction associated with drug treatment, using 5-HT1A receptor antagonists.
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