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    Reagens for the Detection of Protein Acetylation Signaling Pathways
    23.
    发明申请
    Reagens for the Detection of Protein Acetylation Signaling Pathways 审中-公开
    用于检测蛋白质乙酰化信号通路的试剂

    公开(公告)号：US20090124023A1

    公开(公告)日：2009-05-14

    申请号：US12227321

    申请日：2007-05-11

    申请人： Ailan Guo ,  Ting-Lei Gu ,  Jeffrey Mitchell ,  Peter Hornbeck

    发明人： Ailan Guo ,  Ting-Lei Gu ,  Jeffrey Mitchell ,  Peter Hornbeck

    IPC分类号： G01N33/566 ,  C07K16/18

    CPC分类号： G01N33/68 ,  C07K16/18 ,  C07K16/44 ,  G01N33/6842

    摘要： The invention discloses 432 novel acetylation sites identified in signal transduction proteins and pathways underlying human protein acetylation signaling pathways, and provides acetylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these acetylated sites/proteins, as well as methods of using the reagents for such purpose. Among the acetylation sites identified are sites occurring in the following protein types: Acetyltransferases, Adaptor/Scaffold proteins, Actin binding proteins, Adhesion proteins, Apoptosis proteins, Calcium-binding proteins, Cell Cycle Regulation proteins, Cell Surface proteins, DNA binding proteins, DNA replication proteins, Channel proteins, Chaperone proteins, Cellular Metabolism enzymes, Cytoskeletal proteins, DNA repair proteins, Endoplasmic reticulum proteins, Enzyme proteins, G protein and GTPase Activating proteins, Guanine Nucleotide Exchange Factors, Helicase proteins, Isomerase proteins, Extracelluar matrix proteins, Hydrolases, Ligase proteins, Lipid kinases, Inhibtor proteins, Lipid Binding proteins and Lyases.

    摘要翻译： 本发明公开了在信号转导蛋白中鉴定的432个新的乙酰化位点和基于人蛋白质乙酰化信号通路的途径，并提供乙酰化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些乙酰化位点/蛋白质 ，以及使用试剂用于此目的的方法。 确定的乙酰化位点之间的位点是发生在以下蛋白质类型中的位点：乙酰转移酶，适配器/支架蛋白，肌动蛋白结合蛋白，粘附蛋白，细胞凋亡蛋白，钙结合蛋白，细胞周期调节蛋白，细胞表面蛋白，DNA结合蛋白，DNA 复制蛋白，通道蛋白，伴侣蛋白，细胞代谢酶，细胞骨架蛋白，DNA修复蛋白，内质网蛋白，酶蛋白，G蛋白和GTP酶活化蛋白，鸟嘌呤核苷酸交换因子，Helicase蛋白，异构酶蛋白，Extracelluar基质蛋白，水解酶 ，连接酶蛋白，脂质激酶，抑制蛋白，脂质结合蛋白和裂解酶。