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    Reagens for the detection of protein acetylation signaling pathways
    8.
    发明申请
    Reagens for the detection of protein acetylation signaling pathways 审中-公开
    用于检测蛋白质乙酰化信号通路的试剂

    公开(公告)号：US20090325312A1

    公开(公告)日：2009-12-31

    申请号：US12227320

    申请日：2007-05-11

    申请人： Ailan Guo ,  Ting-Lei Gu ,  Peter Hornbeck ,  Jeffrey Mitchell ,  Yu Li

    发明人： Ailan Guo ,  Ting-Lei Gu ,  Peter Hornbeck ,  Jeffrey Mitchell ,  Yu Li

    IPC分类号： G01N33/566 ,  C07K16/18

    CPC分类号： G01N33/6842 ,  C07K16/44

    摘要： The invention discloses 426 novel acetylation sites identified in signal transduction proteins and pathways underlying human protein acetylation signaling pathways, and provides acetylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these acetylated sites/proteins, as well as methods of using the reagents for such purpose. Among the acetylation sites identified are sites occurring in the following protein types: Methyltransferases, Transcription factors, Transcription coactivators, Translation initiation complex proteins, Oxireductases, Protein kinases, RNA binding proteins, Secreted proteins, Transferases, Transporter proteins, Ubiquitin conjugating system proteins, Motor proteins, Phosphotases, Proteases, Phospholipases, Receptor proteins and Vesicle proteins.

    摘要翻译： 本发明公开了在信号转导蛋白中鉴定的426个新的乙酰化位点和人蛋白质乙酰化信号通路的途径，并提供乙酰化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些乙酰化位点/蛋白质 ，以及使用试剂用于此目的的方法。 确定的乙酰化位点之间的位点是发生在以下蛋白质类型中的位点：甲基转移酶，转录因子，转录共激活因子，翻译起始复合蛋白​​，氧化还原酶，蛋白激酶，RNA结合蛋白，分泌蛋白，转移酶，转运蛋白，泛素缀合系统蛋白，马达 蛋白质，磷酸酶，蛋白酶，磷脂酶，受体蛋白和囊泡蛋白。