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37 条记录 (耗时 0.024 秒)

    Magnetic enzyme detection techniques
    21.
    发明授权
    Magnetic enzyme detection techniques 有权

    公开(公告)号：US07094528B2

    公开(公告)日：2006-08-22

    申请号：US10881316

    申请日：2004-06-30

    申请人： Xuedong Song ,  Shu-Ping Yang ,  Rosann Marie Matthews Kaylor

    发明人： Xuedong Song ,  Shu-Ping Yang ,  Rosann Marie Matthews Kaylor

    IPC分类号： C12Q1/00

    CPC分类号： G01N33/558 ,  C12Q1/04 ,  G01N33/543 ,  G01N33/54326 ,  G01N33/58 ,  G01N33/68

    摘要： A diagnostic test kit for detecting the presence or quantity of an enzyme or enzyme inhibitor is provided. The diagnostic kit utilizes reactive complexes to facilitate the detection of the enzyme or enzyme inhibitor. The reactive complexes include a substrate joined (e.g., covalently bonded, physically adsorbed, etc.) to a reporter and magnetic substance. In one embodiment, for example, a peptide, protein, or glycoprotein substrate is joined to a reporter (e.g., dyed latex particle) and magnetic particle. In this embodiment, the substrate provides a cleavage target for a proteolytic enzyme. Specifically, upon contacting the reactive complexes, the proteolytic enzyme cleaves the substrate and releases the reporter and/or magnetic particle. The signal exhibited by the released reporters may then be used to indicate the presence or quantity of an enzyme or enzyme inhibitor within the test sample.

    Compositions for vaginal treatment
    22.
    发明申请
    Compositions for vaginal treatment 有权
    阴道治疗组合

    公开(公告)号：US20050203032A1

    公开(公告)日：2005-09-15

    申请号：US10801063

    申请日：2004-03-15

    申请人： Shu-Ping Yang ,  Yanbin Huang

    发明人： Shu-Ping Yang ,  Yanbin Huang

    IPC分类号： A61K9/00 ,  A61K31/7024

    CPC分类号： A61K31/7024

    摘要： The invention provides mannose phosphate and salts thereof for increasing vaginal cell growth, vaginal cell maturation and vaginal moisture, as well as compositions, articles and methods for treating and preventing vaginal conditions characterized by poor vaginal cell growth, low vaginal cell differentiation and low vaginal moisture.

    摘要翻译： 本发明提供了用于增加阴道细胞生长，阴道细胞成熟和阴道水分的甘露糖磷酸盐及其盐，以及用于治疗和预防以阴道细胞生长差，阴道细胞分化低和阴道湿度为特征的阴道病症的组合物，制品和方法 。

    Anti-chrondrosarcoma compounds
    23.
    发明授权
    Anti-chrondrosarcoma compounds 有权
    抗软骨肉瘤复合物

    公开(公告)号：US07189700B2

    公开(公告)日：2007-03-13

    申请号：US10601059

    申请日：2003-06-20

    申请人： Shu-Ping Yang ,  Stephen Quirk

    发明人： Shu-Ping Yang ,  Stephen Quirk

    IPC分类号： A61K38/00 ,  A61K38/04

    CPC分类号： A61K38/08 ,  A61K38/10 ,  A61K38/55

    摘要： The invention provides inhibitors of chondrosarcoma cell growth that are useful as anti-cancer and anti-tumor agents. The inhibitors are peptides having sequences related to cleavage regions of the proenzyme forms of matrix metalloproteinases and that can inhibit the activity of matrix metalloproteinases. The peptide inhibitors of the invention can be formulated into therapeutic compositions, lotions, creams and wound dressings.

    摘要翻译： 本发明提供了可用作抗癌剂和抗肿瘤剂的软骨肉瘤细胞生长抑制剂。 抑制剂是具有与基质金属蛋白酶的酶原形式的切割区相关的序列并且可以抑制基质金属蛋白酶的活性的肽。 本发明的肽抑制剂可以配制成治疗组合物，洗剂，霜剂和伤口敷料。

    Antimicrobial composition
    24.
    发明申请
    Antimicrobial composition 审中-公开
    抗微生物组成

    公开(公告)号：US20070048345A1

    公开(公告)日：2007-03-01

    申请号：US11364799

    申请日：2006-02-28

    申请人： Lei Huang ,  Shu-Ping Yang ,  Ali Yahiaoui ,  Anthony Spencer

    发明人： Lei Huang ,  Shu-Ping Yang ,  Ali Yahiaoui ,  Anthony Spencer

    IPC分类号： A01N43/40 ,  A01N25/00 ,  A01N37/30

    CPC分类号： A01N31/02 ,  A01N25/30 ,  A01N33/12 ,  A01N43/40 ,  A01N47/44 ,  A01N2300/00

    摘要： An antimicrobial composition that contains an antimicrobial agent and a sugar alcohol is provided. The sugar alcohol is more generally more biocompatible and biodegradable than the antimicrobial agent. In addition, without intending to be limited by theory, it is believed that sugar alcohols increase the attraction of the antimicrobial agent to microorganisms (e.g., the cytoplasmic membrane of bacteria). Because a greater percentage of the antimicrobial agent molecules are brought into contact with the microorganisms, the efficiency of growth inhibition is increased. Thus, the antimicrobial composition provides good efficacy without the need for high levels of an antimicrobial agent.

    摘要翻译： 提供了含有抗微生物剂和糖醇的抗微生物组合物。 糖醇通常比抗微生物剂更生物相容性和生物降解性。 此外，不希望受理论限制，据信糖醇增加了抗微生物剂对微生物（例如细菌的细胞质膜）的吸引力。 因为较大比例的抗微生物剂分子与微生物接触，所以生长抑制的效率增加。 因此，抗微生物组合物提供良好的效力，而不需要高水平的抗微生物剂。

    Method for inhibiting and/or treating vaginal infection
    25.
    发明申请
    Method for inhibiting and/or treating vaginal infection 审中-公开
    用于抑制和/或治疗阴道感染的方法

    公开(公告)号：US20060223765A1

    公开(公告)日：2006-10-05

    申请号：US11094496

    申请日：2005-03-30

    申请人： Lei Huang ,  Shu-Ping Yang

    发明人： Lei Huang ,  Shu-Ping Yang

    IPC分类号： A61K31/715 ,  A61K31/7024

    CPC分类号： A61K31/00 ,  A61K31/7032

    摘要： A method for inhibiting and/or treating infection in a vagina is provided. The method comprises exposing one or more microbes to a treatment composition. The microbes are selected from the group consisting of Gardnerella, Candida, and Trichomonas, and the treatment composition comprises an effective amount of a saccharide-based nonionic surfactant. For example, in one embodiment, the saccharide-based nonionic surfactant is an alkyl glycoside.

    摘要翻译： 提供了用于抑制和/或治疗阴道感染的方法。 该方法包括将一种或多种微生物暴露于治疗组合物。 微生物选自加德纳菌，念珠菌和滴虫，并且处理组合物包含有效量的基于糖的非离子表面活性剂。 例如，在一个实施方案中，糖类非离子表面活性剂是烷基糖苷。

    Method for preventing and/or treating vaginal and vulval infections
    26.
    发明申请
    Method for preventing and/or treating vaginal and vulval infections 审中-公开
    预防和/或治疗阴道和外阴感染的方法

    公开(公告)号：US20060217443A1

    公开(公告)日：2006-09-28

    申请号：US11091205

    申请日：2005-03-28

    申请人： Lei Huang ,  Shu-Ping Yang

    发明人： Lei Huang ,  Shu-Ping Yang

    IPC分类号： A61K31/192

    CPC分类号： A61K31/192

    摘要： The invention provides a method for treating and/or preventing a wide scope of vaginal and vulval infections, such as those caused by bacteria, parasites or yeasts, by administering gallic acid to a subject in need of treatment. A composition containing gallic acid for treating vaginal infections is also disclosed. It has been found that gallic acid is capable of selectively inhibiting the growth of Trichomonas vaginalis, a parasite that causes trichomonas vaginitis; Gardnerella vaginalis, a bacterium that causes bacterial vaginosis; and Candida albicans, a yeast that causes candidiasis and vulvitis; while not inhibiting the growth of Lactobacillus acidophilus, the dominant bacteria in a healthy vaginal ecosystem. Gallic acid is safe and cost-effective, and can be used alone or incorporated into different vaginal health products to treat and/or prevent vaginal infections.

    摘要翻译： 本发明提供了一种通过向需要治疗的受试者施用没食子酸来治疗和/或预防广泛范围的阴道和外阴感染（例如由细菌，寄生虫或酵母引起的）感染的方法。 还公开了含有没食子酸用于治疗阴道感染的组合物。 已经发现没食子酸能够选择性地抑制阴道毛滴虫的生长，阴道毛滴虫是导致滴虫性阴道炎的寄生虫; 阴道加德纳菌是引起细菌性阴道炎的细菌; 和白色念珠菌，一种引起念珠菌病和外阴炎的酵母菌; 而不抑制嗜酸乳杆菌的生长，这是健康阴道生态系统中的主要细菌。 没食子酸是安全和成本有效的，并且可以单独使用或并入不同的阴道保健产品中以治疗和/或预防阴道感染。

    Urogenital infection inhibition
    27.
    发明申请
    Urogenital infection inhibition 审中-公开
    泌尿生殖器感染抑制

    公开(公告)号：US20060127459A1

    公开(公告)日：2006-06-15

    申请号：US11012758

    申请日：2004-12-15

    申请人： Lei Huang ,  Shu-Ping Yang ,  Yanbin Huang

    发明人： Lei Huang ,  Shu-Ping Yang ,  Yanbin Huang

    IPC分类号： A61K31/765 ,  A61K9/70

    CPC分类号： A61K9/0034 ,  A61K9/0036 ,  A61K31/75 ,  A61K31/765

    摘要： There is provided compositions and methods to inhibit the adherence of pathogenic microorganisms to cells. The composition includes water soluble PEO/PEG polymers which may be hydrophilic or amphiphilic block copolymers. One example of a suitable composition is polyethylene glycol or polyethylene oxide with a chemical formula of H—(OCH2CH2)n-OH. Another example of a suitable composition is amphiphilic block copolymer with a chemical formula PEOm-Xp-PEOn, where PEO is —(OCH2CH2)n-O and X is PPO(—(OCH2CH2CH2)m-), or PLGA (poly(lactic-co-glycolic acid), or PMMA (polymethyl methacrylate), or PBO (polybutylene oxide). The pathogenic microorganism may be a bacterial, fungal, viral or trichomonial pathogen and the composition prevents adherence of the pathogenic microorganism in, for example, a urogenital tract of a mammal and aids in reducing malodor generation. The composition may be applied to vaginal health products like, for example, moisturizer, gel, jelly, cream, insert (tablet), ointment, foam. The composition may also be applied to a feminine hygiene product, like, for example, a tampon, feminine pad, feminine wipe or panty liners.

    摘要翻译： 提供了抑制致病微生物对细胞的粘附的组合物和方法。 该组合物包括可以是亲水性或两亲性嵌段共聚物的水溶性PEO / PEG聚合物。 合适组合物的一个实例是具有化学式为H-（OCH 2 CH 2）n -OH的聚乙二醇或聚环氧乙烷。 合适的组合物的另一个实例是具有化学式PEOm-Xp-PEOn的两亲嵌段共聚物，其中PEO是 - （OCH2CH2）nO，X是PPO（ - （OCH2CH2CH2）m-）或PLGA（聚（乳酸 - 乙醇酸）或PMMA（聚甲基丙烯酸甲酯）或PBO（聚环氧丁烷），病原微生物可以是细菌，真菌，病毒或毛滴虫病原体，并且该组合物可防止病原微生物在例如泌尿生殖道 哺乳动物，有助于减少恶臭的产生，该组合物可用于例如保湿剂，凝胶，果冻，霜剂，插入物（片剂），软膏，泡沫等阴道保健品，该组合物也可用于女性卫生 产品，例如，棉塞，女性衬垫，女性擦拭物或内裤衬里。