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公开(公告)号：US20090030076A1
公开(公告)日：2009-01-29
申请号：US12210975
申请日：2008-09-15
IPC分类号： A61K31/215 , C07C69/22 , A61P27/02
CPC分类号： C07C405/0016
摘要： Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的前列腺素硝基衍生物。 可用于治疗青光眼和高眼压症。
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公开(公告)号：US20080090857A1
公开(公告)日：2008-04-17
申请号：US11905893
申请日：2007-10-05
IPC分类号： A61K31/505 , A61P29/00 , A61P7/00 , A61P9/00 , C07D239/42
CPC分类号： C07D207/34 , C07D209/24 , C07D213/55 , C07D239/42
摘要： Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
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公开(公告)号：US07297808B2
公开(公告)日：2007-11-20
申请号：US11590770
申请日：2006-11-01
IPC分类号： C07C205/00 , C07C331/00 , C07C203/00 , C07C381/00 , A01N37/00 , A61K31/21
CPC分类号： C07D207/34 , C07D209/24 , C07D213/55 , C07D239/42
摘要： Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
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公开(公告)号：US07166638B2
公开(公告)日：2007-01-23
申请号：US10849561
申请日：2004-05-20
IPC分类号： A61K31/40 , A61K31/401 , C07D209/10 , C07D207/325
CPC分类号： C07D207/34 , C07D209/24 , C07D213/55 , C07D239/42
摘要： Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
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公开(公告)号：US07166605B2
公开(公告)日：2007-01-23
申请号：US10503128
申请日：2003-03-19
CPC分类号： C07D295/15 , C07C323/20
摘要： Probucol derivatives and pharmaceutical compositions containing the same to be employed in treatment or prophylaxis of diseases.
摘要翻译： 普罗布考衍生物和含有它们的药物组合物用于治疗或预防疾病。
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公开(公告)号：US20050165084A1
公开(公告)日：2005-07-28
申请号：US10849561
申请日：2004-05-20
IPC分类号： A61K31/21 , A61K31/40 , A61K31/404 , A61K31/405 , A61P3/06 , C07D207/34 , C07D209/10 , C07D209/24 , C07D209/26 , C07D213/55 , C07D239/42
CPC分类号： C07D207/34 , C07D209/24 , C07D213/55 , C07D239/42
摘要： Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的他汀类硝基衍生物。 它们可以用于治疗和/或预防多种疾病，特别是冠状动脉综合征，神经变性疾病以及降低胆固醇水平。
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公开(公告)号：US20110136904A1
公开(公告)日：2011-06-09
申请号：US13025740
申请日：2011-02-11
IPC分类号： A61K31/222 , C07C69/732 , A61P27/06
CPC分类号： C07C405/0016
摘要： Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的前列腺素硝基衍生物。 可用于治疗青光眼和高眼压症。
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28.发明授权Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive 失效卡维地洛和其他β受体阻滞剂的硝基氧化酶作为抗高血压药物公开(公告)号：US07825263B2
公开(公告)日：2010-11-02
申请号：US10577912
申请日：2004-12-01
IPC分类号： C07D209/82 , A61K31/403
CPC分类号： C07C219/14 , C07C219/06 , C07C233/33 , C07C235/08 , C07C235/42 , C07C311/08 , C07C2601/08 , C07C2602/10 , C07D209/88
摘要： The present invention relates to β-adrenergic blockers nitrooxyderivatives of general formula (I): A-(Y—ONO2)s and enantiomers and diastereoisomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them and their use for the treatment of hypertension, cardiovascular diseases, glaucoma, migraine headache and vascular diseases.
摘要翻译： 本发明涉及通式（I）：A-（Y-ONO 2）s及其对映异构体和非对映异构体及其药学上可接受的盐，其含有它们的药物组合物及其用于治疗高血压，心血管的用途的β-肾上腺素能阻滞剂 疾病，青光眼，偏头痛和血管疾病。
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公开(公告)号：US07812039B2
公开(公告)日：2010-10-12
申请号：US11984151
申请日：2007-11-14
申请人： Piero Del Soldato , Ennio Ongini
发明人： Piero Del Soldato , Ennio Ongini
IPC分类号： A61K31/44
CPC分类号： A61K31/4184 , A61K31/21 , A61K31/425 , A61K31/55 , A61K31/60 , A61K31/7024 , C07C203/04 , C07C291/02
摘要： Nitro-oxyderivative compounds or salts thereof having the following general formula (I): A-(B)b0-(C)o0-N02 wherein: c0 is an integer and is 0 or 1, b0 is an integer and is 0 or 1, A=R-TI-, wherein R is the radical of an analgesic drug for the chronic pain, in particular for the neuropathic pain; B is such that its precursor is selected from aminoacids, hydroxyacids, polyalcohols, compounds containing at least one acid function; C is a bivalent radical containing an aliphatic, heterocyclic or aromatic radical.
摘要翻译： 具有以下通式（I）的硝基 - 氧化衍生化合物或其盐：A-（B）b0-（C）o0-N02其中：c0为整数，为0或1，b0为整数，为0或1 A = R-TI-，其中R是用于慢性疼痛的镇痛药物的基团，特别是神经性疼痛; B的前体选自氨基酸，羟基酸，多元醇，含有至少一个酸官能团的化合物; C是含有脂族，杂环或芳族基团的二价基团。
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公开(公告)号：US20100130507A1
公开(公告)日：2010-05-27
申请号：US12613985
申请日：2009-11-06
IPC分类号： A61K31/557 , C07C405/00 , C07C327/04 , C07D295/10 , C07D211/30 , A61K31/4965
CPC分类号： C07C405/0016
摘要： Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的前列腺素硝基衍生物。 可用于治疗青光眼和高眼压症。
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