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公开(公告)号：US20080058392A1
公开(公告)日：2008-03-06
申请号：US11841628
申请日：2007-08-20
IPC分类号： A61K31/192 , A61K31/433 , A61P27/06 , C07C229/06
CPC分类号： C07C405/0016
摘要： Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的前列腺素硝基衍生物。 可用于治疗青光眼和高眼压症。
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公开(公告)号：US07629345B2
公开(公告)日：2009-12-08
申请号：US12210975
申请日：2008-09-15
IPC分类号： A61K31/4965 , A61K31/49 , C07C69/76
CPC分类号： C07C405/0016
摘要： Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的前列腺素硝基衍生物。 可用于治疗青光眼和高眼压症。
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公开(公告)号：US07449469B2
公开(公告)日：2008-11-11
申请号：US11841628
申请日：2007-08-20
IPC分类号： A61K31/4965 , A61K31/49
CPC分类号： C07C405/0016
摘要： Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的前列腺素硝基衍生物。 可用于治疗青光眼和高眼压症。
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公开(公告)号：US07910767B2
公开(公告)日：2011-03-22
申请号：US12613985
申请日：2009-11-06
IPC分类号： C07C69/76 , A61K31/4965 , A61K31/49
CPC分类号： C07C405/0016
摘要： Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
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公开(公告)号：US20110136904A1
公开(公告)日：2011-06-09
申请号：US13025740
申请日：2011-02-11
IPC分类号： A61K31/222 , C07C69/732 , A61P27/06
CPC分类号： C07C405/0016
摘要： Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的前列腺素硝基衍生物。 可用于治疗青光眼和高眼压症。
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公开(公告)号：US20100130507A1
公开(公告)日：2010-05-27
申请号：US12613985
申请日：2009-11-06
IPC分类号： A61K31/557 , C07C405/00 , C07C327/04 , C07D295/10 , C07D211/30 , A61K31/4965
CPC分类号： C07C405/0016
摘要： Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的前列腺素硝基衍生物。 可用于治疗青光眼和高眼压症。
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公开(公告)号：US08058467B2
公开(公告)日：2011-11-15
申请号：US13025740
申请日：2011-02-11
CPC分类号： C07C405/0016
摘要： Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的前列腺素硝基衍生物。 可用于治疗青光眼和高眼压症。
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公开(公告)号：US20090030076A1
公开(公告)日：2009-01-29
申请号：US12210975
申请日：2008-09-15
IPC分类号： A61K31/215 , C07C69/22 , A61P27/02
CPC分类号： C07C405/0016
摘要： Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的前列腺素硝基衍生物。 可用于治疗青光眼和高眼压症。
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公开(公告)号：US20070060586A1
公开(公告)日：2007-03-15
申请号：US10581450
申请日：2004-12-01
IPC分类号： A61K31/5377 , A61K31/4704 , A61K31/405 , A61K31/34 , A61K31/21
CPC分类号： C07D285/10
摘要： The present invention relates to β-adrenergic blockers nitrooxyderivatives of general formula (I): A-(Y—ONO2)s and enantiomers and diastereoisomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them and their use for the treatment of hypertension, cardiovascular diseases, glaucoma, migraine headache and vascular diseases.
摘要翻译： 本发明涉及通式（I）的β-肾上腺素能阻断剂硝基氧基衍生物：其对映异构体和非对映异构体及其药学上可接受的盐， 含有它们的药物组合物及其用于治疗高血压，心血管疾病，青光眼，偏头痛和血管疾病的用途。
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公开(公告)号：US20080096908A1
公开(公告)日：2008-04-24
申请号：US11905910
申请日：2007-10-05
IPC分类号： A61K31/404 , A61K31/215 , A61K31/44 , A61P9/00 , C07D207/333 , C07D213/26 , C07D239/42 , C07D209/04 , C07C69/66 , A61K31/505 , A61K31/40
CPC分类号： C07D207/34 , C07D209/24 , C07D213/55 , C07D239/42
摘要： Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的他汀类硝基衍生物。 它们可用于治疗和/或预防多种疾病，特别是冠状动脉综合征，神经变性疾病以及降低胆固醇水平。
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