公开(公告)号：US20170283778A1

公开(公告)日：2017-10-05

申请号：US15507083

申请日：2015-08-25

Applicant: HIROSAKI UNIVERSITY ,  OSAKA UNIVERSITY

Inventor： Hiroshi SHIMODA ,  Yoshiya ASANO ,  Mitsuru AKASHI ,  Michiya MATSUSAKI

IPC: C12N5/071

CPC classification number: C12N5/0697 ,  C12N11/02 ,  C12N2502/1192 ,  C12N2502/1323 ,  C12N2502/28 ,  C12N2513/00 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/90

Abstract: The present disclosure relates to: an artificial peritoneal tissue comprising a cellular tissue and a mesothelial cell layer that covers the surface of the cellular tissue, wherein the cellular tissue comprises a fibroblast, an extracellular matrix, and a vascular endothelial cell and/or a lymphatic endothelial cell each capable of forming a lumen; and a method for producing the artificial peritoneal tissue.

公开(公告)号：US20220130280A1

公开(公告)日：2022-04-28

申请号：US17441602

申请日：2020-03-25

Applicant: OSAKA UNIVERSITY

Inventor： Michiya MATSUSAKI ,  Agathe Elisabeth Marie FIGAROL ,  Kaoru SATO

IPC: G09B23/30 ,  C12N5/079

Abstract: Disclosed is a brain blood vessel model composed of a three-dimensional tissue containing defibrated extracellular matrix components and cells including brain microvascular endothelial cells, pericytes, and astrocytes, wherein at least a portion of the above-described cells adheres to the above-described defibrated extracellular matrix.

公开(公告)号：US20210063374A1

公开(公告)日：2021-03-04

申请号：US16644059

申请日：2018-09-03

Applicant: TOPPAN PRINTING CO., LTD. ,  OSAKA UNIVERSITY

Inventor： Michiya MATSUSAKI ,  Shiro KITANO ,  Shinji IRIE

IPC: G01N33/15 ,  C12N5/077 ,  C07K14/78

Abstract: The present invention relates to an abnormal cardiac rhythm myocardial model composed of a three-dimensional tissue containing cells including the cardiomyocytes and collagen, wherein at least a portion of the cells adheres to the collagen.

公开(公告)号：US20250002865A1

公开(公告)日：2025-01-02

申请号：US18704322

申请日：2022-10-27

Applicant: TOPPAN Holdings Inc. ,  OSAKA UNIVERSITY ,  KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION

Inventor： Shiro KITANO ,  Michiya MATSUSAKI ,  Fiona LOUIS ,  Yoshihiro SOWA

IPC: C12N5/071

Abstract: There is provided a method for producing a tissue construct comprising vascular endothelial cells, the method comprising incubating cells comprising at least adipose-derived stem cells from human in the presence of a TGFβ type I receptor inhibitor.

公开(公告)号：US20210238542A1

公开(公告)日：2021-08-05

申请号：US17050731

申请日：2019-05-07

Applicant: TOPPAN PRINTING CO., LTD. ,  OSAKA UNIVERSITY

Inventor： Shiro KITANO ,  Shinji IRIE ,  Michiya MATSUSAKI

IPC: C12N5/00

Abstract: The present invention relates to an extracellular-matrix-containing composition comprising: a fragmented extracellular matrix component, wherein at least a part of the fragmented extracellular matrix component is crosslinked.

公开(公告)号：US20170333598A1

公开(公告)日：2017-11-23

申请号：US15533724

申请日：2015-12-07

Applicant: OSAKA UNIVERSITY ,  TOHOKU UNIVERSITY

Inventor： Mitsuru AKASHI ,  Michiya MATSUSAKI ,  Michiaki UNNO ,  Naoaki SAKATA ,  Gumpei YOSHIMATSU

IPC: A61L27/38 ,  A61K35/28 ,  A61L27/60 ,  C12N5/00

Abstract: An artificial tissue containing pancreatic islet cells, fibroblasts and/or cells capable of differentiating, extracellular matrix, and vascular endothelial cells, in which the fibroblasts and/or the cells capable of differentiating, the extracellular matrix, and the vascular endothelial cells constitute a three-dimensional tissue structure in which a vascular network structure has been formed, and in which the three-dimensional tissue structure contains pancreatic islets constituted by aggregating ten or more of the pancreatic islet cells.