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公开(公告)号：US20210063374A1
公开(公告)日：2021-03-04
申请号：US16644059
申请日：2018-09-03
Applicant: TOPPAN PRINTING CO., LTD. , OSAKA UNIVERSITY
Inventor： Michiya MATSUSAKI , Shiro KITANO , Shinji IRIE
Abstract: The present invention relates to an abnormal cardiac rhythm myocardial model composed of a three-dimensional tissue containing cells including the cardiomyocytes and collagen, wherein at least a portion of the cells adheres to the collagen.
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公开(公告)号：US20180355322A1
公开(公告)日：2018-12-13
申请号：US16104533
申请日：2018-08-17
Applicant: TOPPAN PRINTING CO., LTD. , OSAKA UNIVERSITY
Inventor： Kei TSUKAMOTO , Shinji IRIE , Michiya MATSUSAKI
IPC: C12N5/09
CPC classification number: C12N5/0693 , C12M3/00 , C12N2501/91
Abstract: A method of promoting spheroid formation, including: a preparation step of preparing a mixture obtained by mixing a cell sample with a promoter; and a culture step of culturing, inside a spheroid formation-culture vessel, the mixture obtained in the preparation step, in which the promoter is a polymer in which one or more selected from the group consisting of D-glucosamine, D-galactosamine, D-glucuronic acid, L-iduronic acid, and D-galactose are polymerized.
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公开(公告)号：US20220133952A1
公开(公告)日：2022-05-05
申请号：US17502496
申请日：2021-10-15
Applicant: TOPPAN PRINTING CO., LTD. , OSAKA UNIVERSITY
Inventor： Michiya MATSUSAKI , Shinji IRIE , Shiro KITANO
Abstract: A method may comprises bringing cells suspended in an aqueous medium into contact with a plurality of fragmented collagen pieces and, after the cells brought into contact with the plurality of fragmented collagen pieces and the plurality of fragmented collagen pieces are concentrated, culturing the cells brought into contact with the fragmented collagen pieces, with the plurality of fragmented collagen pieces, to form a three-dimensional tissue.
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4.发明申请公开(公告)号：US20190351098A1
公开(公告)日：2019-11-21
申请号：US16480114
申请日：2018-01-31
Applicant: TOPPAN PRINTING CO., LTD. , OSAKA UNIVERSITY
Inventor： Michiya MATSUSAKI , Shinji IRIE , Shiro KITANO
Abstract: Disclosed is a three-dimensional tissue comprising cells and collagen including endogenous collagen, wherein at least a portion of the cells is adhered to the collagen, and the content of the collagen is from 10 wt % to 90 wt % based on the three-dimensional tissue.
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公开(公告)号：US20210238542A1
公开(公告)日：2021-08-05
申请号：US17050731
申请日：2019-05-07
Applicant: TOPPAN PRINTING CO., LTD. , OSAKA UNIVERSITY
Inventor： Shiro KITANO , Shinji IRIE , Michiya MATSUSAKI
IPC: C12N5/00
Abstract: The present invention relates to an extracellular-matrix-containing composition comprising: a fragmented extracellular matrix component, wherein at least a part of the fragmented extracellular matrix component is crosslinked.
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Patent Agency Ranking
公开(公告)号：US20210115377A1
公开(公告)日：2021-04-22
申请号：US17050734
申请日：2019-05-07
Applicant: TOPPAN PRINTING CO., LTD. , OSAKA UNIVERSITY
Inventor： Shiro KITANO , Shinji IRIE , Michiya MATSUSAKI
Abstract: The present invention relates to an extracellular-matrix-containing composition comprising: a fragmented extracellular matrix component; and an aqueous medium.
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7.发明申请公开(公告)号：US20160238497A1
公开(公告)日：2016-08-18
申请号：US15135919
申请日：2016-04-22
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Yoichi MAKINO , Shinji IRIE
CPC classification number: G01N1/4055 , B01L3/5085 , B01L2300/069 , B01L2300/0829 , B01L2300/0848 , B01L2300/12 , B01L2300/161 , B01L2300/165 , C12M47/06 , C12Q1/68 , G01N1/4005 , G01N33/6842
Abstract: A membrane vesicle recovery device includes: a liquid filler; and at least a fused membrane having a lipid bilayer membrane which covers at least a part of the outer periphery of the liquid filler, in which a content of a membrane vesicle is mixed into the liquid filler through fusing of the membrane vesicle and the fused membrane.
Abstract translation: 膜囊泡回收装置包括：液体填充剂; 并且至少具有脂质双层膜的熔融膜，其覆盖所述液体填充剂的外周的至少一部分，其中膜囊泡的含量通过所述膜囊泡和所述熔融膜的融合而混入所述液体填充剂中 。
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公开(公告)号：US20190049432A1
公开(公告)日：2019-02-14
申请号：US16164989
申请日：2018-10-19
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Shiro KITANO , Kei TSUKAMOTO , Shinji IRIE
IPC: G01N33/50
Abstract: A method of assessing an anti-cancer drug including culturing a cell structure including cancer cells and stromal cells in a presence of at least one anti-cancer drug, and assessing an anti-cancer effect of the at least one anti-cancer drug based on a number of viable cancer cells in the cell structure after the culturing.
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公开(公告)号：US20220411750A1
公开(公告)日：2022-12-29
申请号：US17777786
申请日：2020-11-17
Applicant: TOPPAN INC. , Osaka University
Inventor： Yasuyuki HIRAOKA , Shiro KITANO , Shinji IRIE , Michiya MATSUSAKI
IPC: C12N5/071
Abstract: The present invention relates to a cell structure including cells containing at least hepatocytes and vascular endothelial cells, and extracellular matrix component, wherein the extracellular matrix components are disposed between the cells, and a liver sinusoidal network is provided between the cells.
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公开(公告)号：US20220145242A1
公开(公告)日：2022-05-12
申请号：US17430648
申请日：2021-03-25
Applicant: TOPPAN INC. , OSAKA UNIVERSITY
Inventor： Shiro KITANO , Shinji IRIE , Michiya MATSUSAKI
Abstract: The present invention relates to an extracellular matrix-containing composition containing a fragmented extracellular matrix component and a compound bound or adsorbed to the fragmented extracellular matrix component.
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