公开(公告)号：US07041131B2

公开(公告)日：2006-05-09

申请号：US10411816

申请日：2003-04-11

申请人： Ginger A. Abraham ,  Robert M. Carr, Jr. ,  Tam Huynh ,  Per Otto Hagen ,  Mark Davies

发明人： Ginger A. Abraham ,  Robert M. Carr, Jr. ,  Tam Huynh ,  Per Otto Hagen ,  Mark Davies

IPC分类号： A61F2/06

CPC分类号： A61L27/507 ,  A61L27/24 ,  A61L27/3629 ,  A61L27/40 ,  B29C53/40 ,  B29C53/562

摘要： The invention is directed to bioengineered vascular graft support prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.

公开(公告)号：US06890351B2

公开(公告)日：2005-05-10

申请号：US09949043

申请日：2001-09-07

申请人： Paul L. Termin ,  Robert M. Carr, Jr. ,  Kimberlie D. Condon

发明人： Paul L. Termin ,  Robert M. Carr, Jr. ,  Kimberlie D. Condon

IPC分类号： A61F2/00 ,  A61F2/02 ,  A61F2/06 ,  A61L27/24 ,  A61L27/34 ,  A61L27/58

CPC分类号： A61L27/58 ,  A61F2/02 ,  A61F2/06 ,  A61F2002/30062 ,  A61F2002/3024 ,  A61F2002/30971 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61F2240/001 ,  A61L27/24 ,  A61L27/34 ,  Y10S623/917 ,  C08L89/06

摘要： A bioremodelable prosthesis for treating a patient with a diseased or damaged organs comprising a first layer that contains acid-extracted fibrillar or non-fibrillar collagen, and a second layer derived from the tunica submucosa of the small intestine that provides structural stability, is pliable and is semi-permeable,pe1 59564443.npc wherein the prosthesis undergoes controlled biodegradation occurring with adequate living cell replacement such that the original prosthesis is replaced by the patient's living cells.

摘要翻译： 用于治疗患有或受损器官的患者的生物可修改假体，其包括含有酸提取的纤维状或非纤维状胶原的第一层，以及衍生自提供结构稳定性的小肠粘膜下层的第二层，是柔韧的，并且 是半渗透性的，其中假体经受受控的生物降解，其具有足够的活细胞置换，使得原始假体被患者的活细胞代替。