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公开(公告)号：US5496277A
公开(公告)日：1996-03-05
申请号：US343725
申请日：1994-11-22
CPC分类号： A61F2/90 , A61F2/95 , A61M25/04 , A61F2230/0091 , A61M2025/0293
摘要： An open weave fixation device is secured to a distal end region of a catheter or other diagnostic or treatment device, for either temporarily or permanently fixing the device within a body cavity. In one approach, the fixation element is constructed of braided, helically wound filaments of resilient stainless steel. A sheath surrounds the catheter and fixation element to elastically deform the element into a reduced radius configuration to facilitate insertion and deployment. With the fixation element positioned as desired, the sheath is withdrawn to permit the fixation element to self-expand against body tissue, thus to secure the fixation element and catheter. In all alternative arrangement, a dilatation balloon surrounds a catheter near its distal end, and in turn is surrounded by a plastically deformable fixation element. Following desired positioning, the balloon is dilated to permanently deform the fixation element into contact with body tissue. In either case, the fixation element can be mounted at its distal end, its proximal end or medially, depending upon the particular treatment and the expected duration of fixation. Another approach employs a recovery metal in the fixation element.
摘要翻译： 开放的编织固定装置固定到导管或其它诊断或治疗装置的远端区域，用于临时或永久性地将装置固定在体腔内。 在一种方法中，固定元件由弹性不锈钢的编织的螺旋缠绕的细丝构成。 护套围绕导管和固定元件以将元件弹性变形成减小的半径构型以便于插入和展开。 当固定元件根据需要定位时，护套被抽出以允许固定元件自身膨胀抵抗身体组织，从而固定固定元件和导管。 在所有替代的布置中，扩张气囊围绕其远端附近的导管围绕，并且由塑性可变形的固定元件围绕。 按照期望的定位，气囊膨胀以将固定元件永久变形成与身体组织接触。 在任一情况下，固定元件可以安装在其远端，其近端或中间，这取决于特定治疗和预期的固定持续时间。 另一种方法在固定元件中采用回收金属。
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公开(公告)号：US07909886B2
公开(公告)日：2011-03-22
申请号：US11277406
申请日：2006-03-24
CPC分类号： A61L2/0088 , A61F2/0063 , A61F2/0077 , A61F2/06 , A61F2/105 , A61F2/2412 , A61F2/2475 , A61F2/442 , A61F2002/30062 , A61F2002/30929 , A61F2210/0004 , A61F2310/00365 , A61L27/24 , A61L27/3604 , A61L27/3629 , A61L27/3641 , A61L27/3687 , A61L27/58 , Y10S623/915 , Y10S623/917
摘要： This invention is directed to prosthesis, which, when implanted into a mammalian patient, serves as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patient's living cells. The prosthesis is treated so that it is rendered non-antigenic so as not to elicit a significant humoral immune response. The prosthesis of this invention, in its various embodiments, thus has dual properties. First, it functions as a substitute body part, and second, it functions as bioremodeling template for the ingrowth of host cells.
摘要翻译： 本发明涉及假体，其在植入哺乳动物患者时用作身体部位或组织结构的功能性替代物，并将经受受控的生物降解，伴随患者活细胞的生物模型发生。 治疗假体使其变得非抗原性，以便不引起显着的体液免疫应答。 因此，在其各种实施方案中，本发明的假体具有双重性质。 首先，它用作替代体部分，其次，它用作宿主细胞向内生长的生物模型。
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公开(公告)号：US5733337A
公开(公告)日：1998-03-31
申请号：US417868
申请日：1995-04-07
IPC分类号： A61L27/00 , A61F2/00 , A61F2/02 , A61F2/04 , A61F2/06 , A61F2/08 , A61F2/10 , A61F2/24 , A61F2/28 , A61F2/44 , A61L2/18 , A61L27/24 , A61L27/36 , A61L27/58
CPC分类号： A61L27/3691 , A61L2/18 , A61L27/24 , A61L27/3604 , A61L27/3687 , A61L27/58 , A61F2/0077
摘要： This invention is directed to prosthesis, which, when implanted into a mammalian patient, serve as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patient's living cells. The prosthesis of this invention, in its various embodiments, thus has dual properties. First, it functions as a substitute body part, and second, it functions as bioremodeling template for the ingrowth of host cells.
摘要翻译： 本发明涉及假体，其在植入哺乳动物患者时用作身体部位或组织结构的功能性替代物，并且将经受受控的生物降解，伴随着患者活细胞的生物模型发生。 因此，在其各种实施方案中，本发明的假体具有双重性质。 首先，它用作替代体部分，其次，它用作宿主细胞向内生长的生物模型。
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公开(公告)号：US07060103B2
公开(公告)日：2006-06-13
申请号：US10376788
申请日：2003-02-28
IPC分类号： A61F2/02
CPC分类号： A61L2/0088 , A61F2/0063 , A61F2/0077 , A61F2/06 , A61F2/105 , A61F2/2412 , A61F2/2475 , A61F2/442 , A61F2002/30062 , A61F2002/30929 , A61F2210/0004 , A61F2310/00365 , A61L27/24 , A61L27/3604 , A61L27/3629 , A61L27/3641 , A61L27/3687 , A61L27/58 , Y10S623/915 , Y10S623/917
摘要： A prosthesis, which, when implanted into a mammalian patient, serves as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patients living cells. The prosthesis is treated so that it is rendered non-antigenic so as not to elicit a significant humoral immune response. The prosthesis, in its various embodiments, thus has dual properties. First, it functions as a substitute body part, and second, it functions as bioremodeling template for the ingrowth of host cells.
摘要翻译： 一种假体，当植入哺乳动物患者时，其用作身体部位或组织结构的功能替代物，并将经受受控制的生物降解，伴随着患者活细胞的生物模型发生。 治疗假体使其变得非抗原性，以便不引起显着的体液免疫应答。 因此，假体在其各种实施例中具有双重性质。 首先，它用作替代体部分，其次，它用作宿主细胞向内生长的生物模型。
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公开(公告)号：US06334872B1
公开(公告)日：2002-01-01
申请号：US08889079
申请日：1997-07-07
IPC分类号： A61F200
CPC分类号： A61L27/58 , A61F2/02 , A61F2/06 , A61F2002/30062 , A61F2002/3024 , A61F2002/30971 , A61F2210/0004 , A61F2230/0069 , A61F2240/001 , A61L27/24 , A61L27/34 , Y10S623/917 , C08L89/06
摘要： This invention is directed to a method of treating a patient with diseased or damaged organs comprising administering to said patient a bioremodelable collagen-containing material which promotes the production of structural collagen, vascularization and epithelialization by the ingrowth of patient cells, wherein the material undergoes controlled biodegradation occurring with adequate living cell replacement such that the original implanted graft is bioremodeled by the patient's living cells.
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公开(公告)号：US5378239A
公开(公告)日：1995-01-03
申请号：US80749
申请日：1993-06-22
CPC分类号： A61F2/90 , A61F2/95 , A61M25/04 , A61F2230/0091 , A61M2025/0293
摘要： An open weave fixation device is secured to a distal end region of a catheter or other diagnostic or treatment device, for either temporarily or permanently fixing the device within a body cavity. In one approach, the fixation element is constructed of braided, helically wound filaments of resilient stainless steel. A sheath surrounds the catheter and fixation element to elastically deform the element into a reduced radius configuration to facilitate insertion and deployment. With the fixation element positioned as desired, the sheath is withdrawn to permit the fixation element to self-expand against body tissue, thus to secure the fixation element and catheter. In an alternative arrangement, a dilatation balloon surrounds a catheter near its distal end, and in turn is surrounded by a plastically deformable fixation element. Following desired positioning, the balloon is dilated to permanently deform the fixation element into contact with body tissue. In either case, the fixation element can be mounted at its distal end, its proximal end or medially, depending upon the particular treatment and the expected duration of fixation. Another approach employs a recovery metal in the fixation element.
摘要翻译： 开放的编织固定装置固定到导管或其它诊断或治疗装置的远端区域，用于临时或永久地将装置固定在体腔内。 在一种方法中，固定元件由弹性不锈钢的编织的螺旋缠绕的细丝构成。 护套围绕导管和固定元件以将元件弹性变形成减小的半径构型以便于插入和展开。 当固定元件根据需要定位时，护套被抽出以允许固定元件自身膨胀抵抗身体组织，从而固定固定元件和导管。 在替代布置中，扩张气囊围绕其远端附近的导管围绕，并且由塑性可变形的固定元件围绕。 按照期望的定位，气囊膨胀以将固定元件永久变形成与身体组织接触。 在任一情况下，固定元件可以安装在其远端，其近端或中间，这取决于特定治疗和预期的固定持续时间。 另一种方法在固定元件中采用回收金属。
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公开(公告)号：US06890351B2
公开(公告)日：2005-05-10
申请号：US09949043
申请日：2001-09-07
CPC分类号： A61L27/58 , A61F2/02 , A61F2/06 , A61F2002/30062 , A61F2002/3024 , A61F2002/30971 , A61F2210/0004 , A61F2230/0069 , A61F2240/001 , A61L27/24 , A61L27/34 , Y10S623/917 , C08L89/06
摘要： A bioremodelable prosthesis for treating a patient with a diseased or damaged organs comprising a first layer that contains acid-extracted fibrillar or non-fibrillar collagen, and a second layer derived from the tunica submucosa of the small intestine that provides structural stability, is pliable and is semi-permeable,pe1 59564443.npc wherein the prosthesis undergoes controlled biodegradation occurring with adequate living cell replacement such that the original prosthesis is replaced by the patient's living cells.
摘要翻译： 用于治疗患有或受损器官的患者的生物可修改假体，其包括含有酸提取的纤维状或非纤维状胶原的第一层，以及衍生自提供结构稳定性的小肠粘膜下层的第二层，是柔韧的，并且 是半渗透性的，其中假体经受受控的生物降解，其具有足够的活细胞置换，使得原始假体被患者的活细胞代替。
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公开(公告)号：US5221261A
公开(公告)日：1993-06-22
申请号：US927771
申请日：1992-08-10
CPC分类号： A61F2/90 , A61F2/95 , A61M25/04 , A61F2230/0091 , A61M2025/0293
摘要： An open weave fixation device is secured to a distal end region of a catheter or other diagnostic or treatment device, for either temporarily or permanently fixing the device within a body cavity. In one approach, the fixation element is constructed of braided, helically wound filaments of resilient stainless steel. A sheath surrounds the catheter and fixation element to elastically deform the element into a reduced radius configuration to facilitate insertion and deployment. With the fixation element positioned as desired, the sheath is withdrawn to permit the fixation element to self-expand against body tissue, thus to secure the fixation element and catheter. In an alternative arrangement, a dilation balloon surrounds a catheter near its distal end, and in turn is surrounded by a plastically deformable fixation element. Following desired positioning, the balloon is dilated to permanently deform the fixation element into contact with body tissue. In either case, the fixation element can be mounted at its distal end, its proximal end or medially, dependeing upon the particular treatment and the expected duration of fixation. Another approach employs a recovery metal in the fixation element.
摘要翻译： 开放的编织固定装置固定到导管或其它诊断或治疗装置的远端区域，用于临时或永久地将装置固定在体腔内。 在一种方法中，固定元件由弹性不锈钢的编织的螺旋缠绕的细丝构成。 护套围绕导管和固定元件以将元件弹性变形成减小的半径构型以便于插入和展开。 当固定元件根据需要定位时，护套被抽出以允许固定元件自身膨胀抵抗身体组织，从而固定固定元件和导管。 在替代布置中，扩张气囊围绕其远端附近的导管围绕，并且由塑性可变形的固定元件围绕。 按照期望的定位，气囊膨胀以将固定元件永久变形成与身体组织接触。 在任一情况下，固定元件可以安装在其远端，其近端或中间，取决于特定治疗和预期的固定持续时间。 另一种方法在固定元件中采用回收金属。
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公开(公告)号：US5071407A
公开(公告)日：1991-12-10
申请号：US508854
申请日：1990-04-12
摘要： An open weave fixation device is secured to a distal end region of a catheter or other diagnostic or treatment device, for either temporarily or permanently fixing the device within a body cavity. In one approach, the fixation element is constructed of braided, helically wound filaments of resilient stainless steel. A sheath surrounds the catheter and fixation element to elastically deform the element into a reduced radius configuration to facilitate insertion and deployment. With the fixation element positioned as desired, the sheath is withdrawn to permit the fixation element to self-expand against body tissue, thus to secure the fixation element and catheter. In an alternative arrangement, a dilatation balloon surrounds a catheter near its distal end, and in turn is surrounded by a plastically deformable fixation element. Following desired positioning, the balloon is dilated to permanently deform the fixation element into contact with body tissue. In either case, the fixation element can be mounted at its distal end, its proximal end or medially, depending upon the particular treatment and the expected duration of fixation. Another approach employs a recovery metal in the fixation element.
摘要翻译： 开放的编织固定装置固定到导管或其它诊断或治疗装置的远端区域，用于临时或永久地将装置固定在体腔内。 在一种方法中，固定元件由弹性不锈钢的编织的螺旋缠绕的细丝构成。 护套围绕导管和固定元件以将元件弹性变形成减小的半径构型以便于插入和展开。 当固定元件根据需要定位时，护套被抽出以允许固定元件自身膨胀抵抗身体组织，从而固定固定元件和导管。 在替代布置中，扩张气囊围绕其远端附近的导管围绕，并且由塑性可变形的固定元件围绕。 按照期望的定位，气囊膨胀以将固定元件永久变形成与身体组织接触。 在任一情况下，固定元件可以安装在其远端，其近端或中间，这取决于特定治疗和预期的固定持续时间。 另一种方法在固定元件中采用回收金属。
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