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公开(公告)号：US06890351B2
公开(公告)日：2005-05-10
申请号：US09949043
申请日：2001-09-07
CPC分类号： A61L27/58 , A61F2/02 , A61F2/06 , A61F2002/30062 , A61F2002/3024 , A61F2002/30971 , A61F2210/0004 , A61F2230/0069 , A61F2240/001 , A61L27/24 , A61L27/34 , Y10S623/917 , C08L89/06
摘要： A bioremodelable prosthesis for treating a patient with a diseased or damaged organs comprising a first layer that contains acid-extracted fibrillar or non-fibrillar collagen, and a second layer derived from the tunica submucosa of the small intestine that provides structural stability, is pliable and is semi-permeable,pe1 59564443.npc wherein the prosthesis undergoes controlled biodegradation occurring with adequate living cell replacement such that the original prosthesis is replaced by the patient's living cells.
摘要翻译： 用于治疗患有或受损器官的患者的生物可修改假体，其包括含有酸提取的纤维状或非纤维状胶原的第一层，以及衍生自提供结构稳定性的小肠粘膜下层的第二层，是柔韧的，并且 是半渗透性的，其中假体经受受控的生物降解，其具有足够的活细胞置换，使得原始假体被患者的活细胞代替。
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公开(公告)号：US07060103B2
公开(公告)日：2006-06-13
申请号：US10376788
申请日：2003-02-28
IPC分类号： A61F2/02
CPC分类号： A61L2/0088 , A61F2/0063 , A61F2/0077 , A61F2/06 , A61F2/105 , A61F2/2412 , A61F2/2475 , A61F2/442 , A61F2002/30062 , A61F2002/30929 , A61F2210/0004 , A61F2310/00365 , A61L27/24 , A61L27/3604 , A61L27/3629 , A61L27/3641 , A61L27/3687 , A61L27/58 , Y10S623/915 , Y10S623/917
摘要： A prosthesis, which, when implanted into a mammalian patient, serves as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patients living cells. The prosthesis is treated so that it is rendered non-antigenic so as not to elicit a significant humoral immune response. The prosthesis, in its various embodiments, thus has dual properties. First, it functions as a substitute body part, and second, it functions as bioremodeling template for the ingrowth of host cells.
摘要翻译： 一种假体，当植入哺乳动物患者时，其用作身体部位或组织结构的功能替代物，并将经受受控制的生物降解，伴随着患者活细胞的生物模型发生。 治疗假体使其变得非抗原性，以便不引起显着的体液免疫应答。 因此，假体在其各种实施例中具有双重性质。 首先，它用作替代体部分，其次，它用作宿主细胞向内生长的生物模型。
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公开(公告)号：US06334872B1
公开(公告)日：2002-01-01
申请号：US08889079
申请日：1997-07-07
IPC分类号： A61F200
CPC分类号： A61L27/58 , A61F2/02 , A61F2/06 , A61F2002/30062 , A61F2002/3024 , A61F2002/30971 , A61F2210/0004 , A61F2230/0069 , A61F2240/001 , A61L27/24 , A61L27/34 , Y10S623/917 , C08L89/06
摘要： This invention is directed to a method of treating a patient with diseased or damaged organs comprising administering to said patient a bioremodelable collagen-containing material which promotes the production of structural collagen, vascularization and epithelialization by the ingrowth of patient cells, wherein the material undergoes controlled biodegradation occurring with adequate living cell replacement such that the original implanted graft is bioremodeled by the patient's living cells.
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公开(公告)号：US07909886B2
公开(公告)日：2011-03-22
申请号：US11277406
申请日：2006-03-24
CPC分类号： A61L2/0088 , A61F2/0063 , A61F2/0077 , A61F2/06 , A61F2/105 , A61F2/2412 , A61F2/2475 , A61F2/442 , A61F2002/30062 , A61F2002/30929 , A61F2210/0004 , A61F2310/00365 , A61L27/24 , A61L27/3604 , A61L27/3629 , A61L27/3641 , A61L27/3687 , A61L27/58 , Y10S623/915 , Y10S623/917
摘要： This invention is directed to prosthesis, which, when implanted into a mammalian patient, serves as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patient's living cells. The prosthesis is treated so that it is rendered non-antigenic so as not to elicit a significant humoral immune response. The prosthesis of this invention, in its various embodiments, thus has dual properties. First, it functions as a substitute body part, and second, it functions as bioremodeling template for the ingrowth of host cells.
摘要翻译： 本发明涉及假体，其在植入哺乳动物患者时用作身体部位或组织结构的功能性替代物，并将经受受控的生物降解，伴随患者活细胞的生物模型发生。 治疗假体使其变得非抗原性，以便不引起显着的体液免疫应答。 因此，在其各种实施方案中，本发明的假体具有双重性质。 首先，它用作替代体部分，其次，它用作宿主细胞向内生长的生物模型。
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公开(公告)号：US5733337A
公开(公告)日：1998-03-31
申请号：US417868
申请日：1995-04-07
IPC分类号： A61L27/00 , A61F2/00 , A61F2/02 , A61F2/04 , A61F2/06 , A61F2/08 , A61F2/10 , A61F2/24 , A61F2/28 , A61F2/44 , A61L2/18 , A61L27/24 , A61L27/36 , A61L27/58
CPC分类号： A61L27/3691 , A61L2/18 , A61L27/24 , A61L27/3604 , A61L27/3687 , A61L27/58 , A61F2/0077
摘要： This invention is directed to prosthesis, which, when implanted into a mammalian patient, serve as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patient's living cells. The prosthesis of this invention, in its various embodiments, thus has dual properties. First, it functions as a substitute body part, and second, it functions as bioremodeling template for the ingrowth of host cells.
摘要翻译： 本发明涉及假体，其在植入哺乳动物患者时用作身体部位或组织结构的功能性替代物，并且将经受受控的生物降解，伴随着患者活细胞的生物模型发生。 因此，在其各种实施方案中，本发明的假体具有双重性质。 首先，它用作替代体部分，其次，它用作宿主细胞向内生长的生物模型。
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