公开(公告)号：US08968659B2

公开(公告)日：2015-03-03

申请号：US12683882

申请日：2010-01-07

Applicant: Mark Davies ,  Tara Dalton

Inventor： Mark Davies ,  Tara Dalton

IPC: G01N1/18 ,  G01N1/00 ,  G01N33/00 ,  C40B60/14 ,  B01F5/00 ,  B01F13/00 ,  B01L3/00 ,  B01L7/00 ,  G01N35/08 ,  G01N35/10 ,  G01N35/00

CPC classification number: B01F5/0057 ,  B01F13/0059 ,  B01F13/0071 ,  B01L3/50273 ,  B01L7/525 ,  B01L2200/0636 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/087 ,  B01L2300/185 ,  B01L2400/0409 ,  B01L2400/0487 ,  G01N35/08 ,  G01N35/1095 ,  G01N2035/00514

Abstract: The present invention generally relates to systems and methods for mixing and dispensing a sample droplet from a microfluidic system, such as a liquid bridge system. In certain embodiments, the invention provides systems for mixing and dispensing sample droplets, including a sample acquisition stage, a device for mixing sample droplets to form sample droplets wrapped in an immiscible carrier fluid, a dispensing port, and at least one channel connecting the stage, the droplet mixing device, and the port, in which the system is configured to establish a siphoning effect for dispensing the droplets.

Abstract translation: 本发明一般涉及用于从微流体系统（例如液桥系统）混合和分配样品液滴的系统和方法。 在某些实施方案中，本发明提供了用于混合和分配样品液滴的系统，包括样品采集阶段，用于混合样品液滴以形成包裹在不混溶载体流体中的样品液滴的装置，分配端口和连接该阶段 ，液滴混合装置和端口，其中系统被配置成建立用于分配液滴的虹吸效应。

公开(公告)号：US20140049110A1

公开(公告)日：2014-02-20

申请号：US14112997

申请日：2012-04-19

Applicant: Mark Davies ,  Mike Dommaschk ,  Jörg Lang ,  Klaus Würflinger

Inventor： Mark Davies ,  Mike Dommaschk ,  Jörg Lang ,  Klaus Würflinger

IPC: H02M5/293

CPC classification number: H02M5/293 ,  H02M5/271 ,  H02M5/297 ,  H02M7/49 ,  H02M2007/4835 ,  Y10T307/549

Abstract: A matrix inverter is connected to a first and a second multi-phase A.C. voltage network. First inductive elements are connected to the first A.C. voltage network and second inductive elements are connected to the second A.C. voltage network. A switch matrix connects the ends of the first inductive elements, to the ends of the second inductive elements. The switch matrix has inverter units. A regulation arrangement is connected to control inputs of the inverter units. The matrix inverter has a first inverter unit, which is arranged between the ends of the first inductive circuit elements and earth potential. The matrix inverter has a second inverter unit, connected between the ends of the first inductive circuit elements and the ends of the second inductive circuit elements. The regulation arrangement insures that the electrical power flowing to the matrix inverter is equal to the electrical power flowing out of the matrix inverter.

Abstract translation: 矩阵逆变器连接到第一和第二多相交流电压网络。 第一电感元件连接到第一交流电压网络，第二电感元件连接到第二交流电压网络。 开关矩阵将第一电感元件的端部连接到第二电感元件的端部。 开关矩阵具有逆变器单元。 调节装置连接到逆变器单元的控制输入。 矩阵逆变器具有设置在第一感应电路元件的端部和地电位之间的第一逆变器单元。 矩阵逆变器具有连接在第一感应电路元件的端部和第二感应电路元件的端部之间的第二逆变器单元。 调节装置确保流向矩阵变换器的电力等于从矩阵变换器流出的电力。

公开(公告)号：US08550503B2

公开(公告)日：2013-10-08

申请号：US12443303

申请日：2007-09-27

Applicant: Mark Davies ,  Tara Dalton

Inventor： Mark Davies ,  Tara Dalton

IPC: F16L39/04

CPC classification number: F16L41/18 ,  B01L3/5027 ,  B01L3/5635 ,  B01L3/565 ,  B01L2200/027 ,  F16L39/00 ,  Y10T137/0318

Abstract: A microfluidic connector (1) comprises an enclosure (6, 7), a fluidic inlet port (2) and a fluidic outlet port (3), in the enclosure, in which the inlet and outlet ports (2, 3) are movable with respect to each other, for example, mutual spacing between the inlet and outlet ports (2, 3) is variable. A port (2) is in a fixed part (6) of the enclosure, and another port (3) is in a part (7) of the enclosure which slides with respect to the fixed part. There may be multiple inlet ports (22, 23) and/or multiple outlet ports (24, 25). Also, there may be an auxiliary port (45) for introduction of fluid into the enclosure (47, 48) or removal of fluid from the enclosure.

Abstract translation: 微流体连接器（1）包括外壳中的外壳（6,7），流体入口端口（2）和流体出口端口（3），入口端口和出口端口（2,3）可通过外壳 彼此相对，例如，入口端口（3）之间的相互间隔是可变的。 端口（2）位于外壳的固定部分（6）中，另一个端口（3）位于外壳的相对于固定部分滑动的部分（7）中。 可以有多个入口端口（22,23）和/或多个出口端口（24,25）。 而且，可以存在用于将流体引入外壳（47,48）或从外壳移除流体的辅助端口（45）。

公开(公告)号：US08386180B2

公开(公告)日：2013-02-26

申请号：US12452986

申请日：2008-07-24

Applicant: Mark Davies

Inventor： Mark Davies

IPC: G06F19/00

CPC classification number: G01V7/00 ,  G01V11/00

Abstract: We describe a method of processing geophysical data including at least measured potential field data from a potential field survey of a surveyed region of the earth to provide a three-dimensional representation of the underlying geology of said surveyed region, the method comprising: inputting terrain-corrected potential field data for said surveyed region, said potential field data comprising data for a range of spatial wavelengths, geological features at different depths in said surveyed region being associated with different wavelengths in said range of wavelengths; filtering said potential field data by spatial wavelength to generate a first plurality of filtered sets of potential field data, each relating to a respective wavelength or range of wavelengths, each targeting geological features at a different respective said depth; processing each said filtered set of potential field data, to identify a set of spatial features comprising one or both of line spatial features and point spatial features in each said filtered set of potential field data, and to generate a set of plot data for each said filtered set of potential field data, a said set of plot data representing said identified set of spatial features for a said depth targeted by said filtering; and combining said sets of plot data to generate three-dimensional map data providing a three-dimensional representation of said underlying geology of said surveyed region.

Abstract translation: 我们描述一种处理地球物理数据的方法，包括来自地球测量区域的潜在现场勘测的至少测量的潜在场数据，以提供所述被测区域的基础地质学的三维表示，所述方法包括： 所述电位场数据包括空间波长范围的数据，所述测量区域中不同深度处的地质特征与所述波长范围中的不同波长相关联; 通过空间波长对所述潜在场数据进行滤波，以产生第一多个经滤波的势场数据集合，每一组相关于相应的波长或波长范围，其各自针对相应所述深度处的不同的地质特征; 处理每个所述经过滤波的一组潜在场数据，以识别包括每个所述经过滤波的一组潜在场数据中的线空间特征和点空间特征中的一个或两个的一组空间特征，并且生成用于每个所述 经过滤波的一组潜在场数据，所述一组绘图数据表示由所述滤波所针对的所述深度的所述识别的一组空间特征; 以及组合所述几组绘图数据以产生提供所述被测区域的所述基础地质学的三维表示的三维地图数据。

公开(公告)号：US20110094749A1

公开(公告)日：2011-04-28

申请号：US11795352

申请日：2006-01-16

Applicant: Andrew Richards ,  Mark Davies

Inventor： Andrew Richards ,  Mark Davies

IPC: E21B41/04 ,  E21B34/04

CPC classification number: E21B33/076

Abstract: A well intervention system (10) which is adapted to be coupled to a subsea wellhead assembly (12) is described. The subsea wellhead assembly has a wellhead, a subsea tree (14) coupled to the wellhead and a well control package, having a plurality of well control valves, coupled to the subsea tree. The intervention system (10) comprises a vessel (44) for storing and deploying wireline tooling, first fluid communication means extending between the vessel and a purging fluid supply (57) and second fluid communication means extending between the vessel and the well control package at a location above at least one well control valve. In use, purging fluid applied to the vessel via the first fluid communication means displaces fluid from the vessel into the second fluid communication means and into the well control package. Embodiments of the invention are described.

Abstract translation: 描述适于联接到海底井口组件（12）的井干涉系统（10）。 海底井口组件具有井口，联接到井口的海底树（14）和井控制包，其具有联接到海底树的多个井控制阀。 干预系统（10）包括用于存储和展开电缆工具的容器（44），在容器和清洗流体供应（57）之间延伸的第一流体连通装置和在容器和井控制包装之间延伸的第二流体连通装置 位于至少一个井控制阀上方的位置。 在使用中，通过第一流体连通装置施加到容器的清洗流体使流体从容器移动到第二流体连通装置中并进入井控制包装。 对本发明的实施例进行说明。

公开(公告)号：US20100292973A1

公开(公告)日：2010-11-18

申请号：US12863754

申请日：2008-01-21

Applicant: Gary James Barnes ,  John Morris Lumley ,  Mark Davies ,  Joseph Jean Barraud

Inventor： Gary James Barnes ,  John Morris Lumley ,  Mark Davies ,  Joseph Jean Barraud

IPC: G06G7/48

CPC classification number: G01V7/16

Abstract: A method of processing geophysical data including at least measured potential field data from a potential field survey of a surveyed region of the earth to provide a representation of the geology of said surveyed region, the method comprising generating a first model of said surveyed region by fitting data predicted by said first model to said measured data for a specified frequency range; predicting full range potential field data for all measured frequencies using said generated first model; comparing said full range predicted data to said measured potential field data to provide full range residual data representing a difference between the full range predicted data and the full range measured data, and interpreting said full range residual data to provide a representation of said geology of said surveyed region.

Abstract translation: 一种处理地球物理数据的方法，所述方法包括至少测量的来自地球测量区域的潜在现场勘测的势场数据，以提供所述被测区域的地质的表示，所述方法包括通过拟合来生成所述被测区域的第一模型 由所述第一模型预测的数据对于指定频率范围的所述测量数据; 使用所述生成的第一模型预测所有测量频率的全范围电势场数据; 将所述全范围预测数据与所述测量的电位场数据进行比较，以提供表示全范围预测数据与全范围测量数据之间的差异的全范围残差数据，以及解释所述全范围残差数据以提供所述全范围预测数据的所述地质学 受访地区。

公开(公告)号：US20100216128A1

公开(公告)日：2010-08-26

申请号：US12469339

申请日：2009-05-20

Applicant: Mark Davies ,  Tara Dalton

Inventor： Mark Davies ,  Tara Dalton

IPC: C12Q1/68 ,  C12Q1/02 ,  G01N33/566 ,  G01N33/92 ,  G01N33/00

CPC classification number: G01N1/38 ,  B01F13/0071 ,  B01F15/0201 ,  B01F15/0232 ,  B01L3/502784 ,  B01L3/5088 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/165 ,  G01N33/5308 ,  G01N2035/00237

Abstract: The present invention generally relates methods for analyzing agricultural and/or environmental samples using liquid bridges. In certain embodiments, the invention provides a method for analyzing an agricultural sample for a desired trait including obtaining a gene or gene product from an agricultural sample, in which the gene or gene product is in a first fluid; providing a liquid bridge for mixing the gene or gene product with at least one reagent to form a mixed droplet that is wrapped in an immiscible second fluid; and analyzing the mixed droplet to detect a desired trait of the agricultural sample.

Abstract translation: 本发明一般涉及使用液体桥分析农业和/或环境样品的方法。 在某些实施方案中，本发明提供了一种用于分析所需性状的农业样品的方法，包括从农业样品获得基因或基因产物，其中所述基因或基因产物处于第一种流体中; 提供用于将基因或基因产物与至少一种试剂混合以形成被包裹在不混溶的第二流体中的混合液滴的液体桥; 并分析混合液滴以检测农业样品的期望性状。

公开(公告)号：US20100184906A1

公开(公告)日：2010-07-22

申请号：US12602611

申请日：2008-06-05

Applicant: Mark Davies

Inventor： Mark Davies

IPC: C08L33/12 ,  C08L33/06 ,  C08F20/10 ,  B29C45/72

CPC classification number: C08L69/00 ,  C08J5/043 ,  C08J2369/00 ,  C08J2433/12 ,  C08J2455/00 ,  C08J2455/02 ,  C08L33/06 ,  C08L33/12 ,  C08L51/04 ,  C08L55/02 ,  C08L2207/04 ,  C08L2207/53 ,  C08L2666/02

Abstract: A composition comprising a mixture of: (i) an aromatic polycarbonate; (ii) a graft copolymer including polyacrylonitrile; and, (iii) a non-crosslinked acrylic polymer having a weight average molecular weight (Mw) of less than or equal to 65,000 Daltons (Da).

Abstract translation: 一种组合物，其包含以下混合物：（i）芳族聚碳酸酯; （ii）包含聚丙烯腈的接枝共聚物; 和（iii）重均分子量（Mw）小于或等于65,000道尔顿（Da）的非交联丙烯酸类聚合物。

公开(公告)号：US20100120635A1

公开(公告)日：2010-05-13

申请号：US12683882

申请日：2010-01-07

Applicant: MARK DAVIES ,  Tara Dalton

Inventor： MARK DAVIES ,  Tara Dalton

IPC: C40B50/06 ,  C40B60/14

CPC classification number: B01F5/0057 ,  B01F13/0059 ,  B01F13/0071 ,  B01L3/50273 ,  B01L7/525 ,  B01L2200/0636 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/087 ,  B01L2300/185 ,  B01L2400/0409 ,  B01L2400/0487 ,  G01N35/08 ,  G01N35/1095 ,  G01N2035/00514

Abstract: The present invention generally relates to systems and methods for mixing and dispensing a sample droplet from a microfluidic system, such as a liquid bridge system. In certain embodiments, the invention provides systems for mixing and dispensing sample droplets, including a sample acquisition stage, a device for mixing sample droplets to form sample droplets wrapped in an immiscible carrier fluid, a dispensing port, and at least one channel connecting the stage, the droplet mixing device, and the port, in which the system is configured to establish a siphoning effect for dispensing the droplets.

Abstract translation: 本发明一般涉及用于从微流体系统（例如液桥系统）混合和分配样品液滴的系统和方法。 在某些实施方案中，本发明提供了用于混合和分配样品液滴的系统，包括样品采集阶段，用于混合样品液滴以形成包裹在不混溶载体流体中的样品液滴的装置，分配端口和连接该阶段 ，液滴混合装置和端口，其中系统被配置成建立用于分配液滴的虹吸效应。

公开(公告)号：US20100092973A1

公开(公告)日：2010-04-15

申请号：US12539343

申请日：2009-08-11

Applicant: Mark Davies ,  Tara Dalton

Inventor： Mark Davies ,  Tara Dalton

IPC: C12Q1/68

CPC classification number: C12Q1/6851 ,  B01L3/502784 ,  B01L7/525 ,  B01L2300/0838 ,  B01L2300/0867 ,  B01L2400/0487 ,  C12Q2561/101 ,  C12Q2563/159 ,  C12Q2565/629

Abstract: The invention provides methods of conducting a nucleic acid reaction, including methods for performing digital PCR using a “droplet-in-oil” technology. In the methods, the starting sampled is segmented at least partially into a set of sample droplets each containing on average about one or fewer copies of a target nucleic acid. The droplets are passed in a continuous flow of immiscible carrier fluid through a channel that passes through a thermal cycler, whereby the target is amplified. In one implementation, the droplets are about 350 nl each and the number of positively amplified droplets is counted at the near-saturation point.

Abstract translation: 本发明提供了进行核酸反应的方法，包括使用“油滴技术”进行数字PCR的方法。 在所述方法中，起始取样至少部分地分成一组样品液滴，每个样品液滴平均含有约一个或更少个靶核酸拷贝。 液滴通过穿过热循环仪的通道在不混溶的载体流体的连续流中通过，从而靶扩增。 在一个实施方案中，液滴各自为约350nl，并且在近饱和点处计数积极扩增的液滴的数量。