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    PDE1 inhibitor compounds
    23.
    发明授权
    PDE1 inhibitor compounds 有权
    PDE1抑制剂化合物

    公开(公告)号：US09371327B2

    公开(公告)日：2016-06-21

    申请号：US13701225

    申请日：2011-05-31

    Applicant: Peng Li ,  Jun Zhao

    Inventor： Peng Li ,  Jun Zhao

    IPC: A01N43/90 ,  A61K31/519 ,  C07D487/00 ,  C07D487/04 ,  A61K31/5575 ,  A61K45/06 ,  A61K31/165

    CPC classification number: C07D487/04 ,  A61K31/165 ,  A61K31/519 ,  A61K31/5575 ,  A61K45/06 ,  A61K2300/00

    Abstract: The present invention relates to optionally substituted (5- or 7-oxy)-3,4-dihydro-(optionally 4-oxo, 4-thioxo or 4-imino)-1H-pyrrolo[3,4-d]pyrimidin-2(3H,6H)-ones, e.g., Compounds of Formula II-A′ or II-B′ as described herein, processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them.

    Abstract translation: 本发明涉及任选取代的（5-或7-氧）-3,4-二氢 - （任选4-氧代，4-硫代或4-亚氨基）-1H-吡咯并[3,4-d]嘧啶-2 （3H，6H） - 酮，例如本文所述的式II-A'或II-B'的化合物，其制备方法，其用作药物和包含它们的药物组合物。

    Optionally substituted 3-amino-4-(thioxo or imino)-4,5-dihydro-2H-pyrazolo [3,4-d]pyrimidin-6(7H)-ones
    25.
    发明授权
    Optionally substituted 3-amino-4-(thioxo or imino)-4,5-dihydro-2H-pyrazolo [3,4-d]pyrimidin-6(7H)-ones 有权
    取代的3-氨基-4-（硫代或亚氨基）-4,5-二氢-2H-吡唑并[3,4-d]嘧啶-6（7H） - 酮

    公开(公告)号：US08697710B2

    公开(公告)日：2014-04-15

    申请号：US13132955

    申请日：2009-12-07

    Applicant: Peng Li ,  Jun Zhao ,  Hailin Zeng ,  Lawrence Wennogle

    Inventor： Peng Li ,  Jun Zhao ,  Hailin Zeng ,  Lawrence Wennogle

    IPC: A01N43/90 ,  A61K31/519 ,  C07D487/00

    CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K31/522 ,  A61K31/56 ,  A61K45/06 ,  A61K2300/00

    Abstract: The present invention relates to optionally substituted 3-amino-4,5-dihydro-(1H or 2H)-pyrazolo[3,4-d]pyrimidin-6(7H)-ones and their 4-imino or 4-thioxo derivatives, e.g., 3-amino-4-(thioxo or imino)-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-6(7H)-ones, 3-amino-4-(thioxo or imino)-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-6(7H)-ones, 3-amino-4-(thioxo or imino)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6(7H)-ones, processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them.

    Abstract translation: 本发明涉及任选取代的3-氨基-4,5-二氢 - （1H或2H） - 吡唑并[3,4-d]嘧啶-6（7H） - 酮及其4-亚氨基或4-硫代衍生物， 例如3-氨基-4-（硫代或亚氨基）-4,5-二氢-2H-吡唑并[3,4-d]嘧啶-6（7H） - 酮，3-氨基-4-（硫代或亚氨基） -4,5-二氢-2H-吡唑并[3,4-d]嘧啶-6（7H） - 酮，3-氨基-4-（硫代或亚氨基）-4,5-二氢-1H-吡唑并[ 4-d]嘧啶-6（7H） - 酮，其制备方法，它们作为药物的用途和包含它们的药物组合物。

    PHOSPHODIESTERASE 1-TARGETING TRACERS AND METHODS
    26.
    发明申请
    PHOSPHODIESTERASE 1-TARGETING TRACERS AND METHODS 有权
    磷酸二酯酶1指标追踪器和方法

    公开(公告)号：US20120201754A1

    公开(公告)日：2012-08-09

    申请号：US13500941

    申请日：2010-10-07

    Applicant: Peng Li ,  Lawrence P. Wennogle ,  Jun Zhao ,  Hailin Zheng

    Inventor： Peng Li ,  Lawrence P. Wennogle ,  Jun Zhao ,  Hailin Zheng

    IPC: A61K51/04 ,  A61P25/00 ,  A61P9/00 ,  C07D473/06 ,  A61P9/12

    CPC classification number: A61K51/0459 ,  C07D473/06 ,  G01T1/1642 ,  G01T1/2985

    Abstract: Tracers targeting phosphodiesterase 1 for use in gamma radiation detection-based diagnostic techniques, particulaly gamma-emitter labeled tracers for SPECT and positron emitter-labeled compositions for PET are disclosed. Radio-labeled multiple novel scaffolds as PDE1 inhibitors such as substituted pyrazolo-pyrimidin-4-one derivatives, biomarkers for phosphodiesterase 1 [PDE1) in vivo, methods for developing novel therapies for PDE1-implicated conditions such as pulmonary arterial hypertension (PAH), Central Nervous System (CNS) and Cardiovascular (CV) disorders, and methods of detection and treatment are also disclosed.

    Abstract translation: 针对磷酸二酯酶1的追踪剂用于基于γ辐射检测的诊断技术，特别是用于SPECT的γ发射体标记的示踪剂和用于PET的正电子发射体标记的组合物。 放射性标记的多种新型支架作为PDE1抑制剂，例如取代的吡唑并嘧啶-4-酮衍生物，用于磷酸二酯酶1 [PDE1]的生物标志物），用于开发PDE1介导性疾病如肺动脉高压（PAH）， 中枢神经系统（CNS）和心血管（CV）疾病，以及检测和治疗方法也被公开。

    Apparatus and method for performing spectroscopic analysis of a subject using a frustum shaped reflective cavity
    30.
    发明授权
    Apparatus and method for performing spectroscopic analysis of a subject using a frustum shaped reflective cavity 有权

    公开(公告)号：US10215703B2

    公开(公告)日：2019-02-26

    申请号：US16053892

    申请日：2018-08-03

    Applicant: Jun Zhao ,  Xin Jack Zhou ,  Sean Xiaolu Wang

    Inventor： Jun Zhao ,  Xin Jack Zhou ,  Sean Xiaolu Wang

    IPC: G01N21/65 ,  G01J3/02 ,  G01J3/44 ,  G01N21/64 ,  G01N21/47

    Abstract: This invention relates to a light delivery and collection device for performing spectroscopic analysis of a subject. The light delivery and collection device comprises a reflective cavity with two apertures. The first aperture receives excitation light which then diverges and projects onto the second aperture. The second aperture is applied to the subject such that the reflective cavity substantially forms an enclosure covering an area of the subject. The excitation light interacts with the covered area of the subject to produce inelastic scattering and/or fluorescence emission from the subject. The reflective cavity reflects the excitation light as well as the inelastic scattering and/or fluorescence emission that is reflected and/or back-scattered from the subject and redirects it towards the subject. This causes more excitation light to penetrate into the subject hence enabling sub-surface measurement and also improves the collection efficiency of the inelastic scattering or fluorescence emission. The shape of the reflective cavity is optimized to further improve the collection efficiency.

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