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    HOLLOW FIBER SCREENING TOOL, SYSTEM, AND METHOD
    23.
    发明申请
    HOLLOW FIBER SCREENING TOOL, SYSTEM, AND METHOD 有权

    公开(公告)号：US20230098953A1

    公开(公告)日：2023-03-30

    申请号：US17936426

    申请日：2022-09-29

    Applicant: Repligen Corporation

    Inventor： James Peyser ,  Michael Bransby ,  Philip Yuen

    IPC: C12M1/00 ,  G01N15/08

    Abstract: A filter screening tool, system, and method allowing high throughput screening of filters (such as hollow fiber filters), such as for use in bioprocessing workflows. Feed material may be fed through different filter modules to assess, measure, analyze, determine, evaluate, teste, compare, screen, etc., properties or characteristics, etc., of filters within the filter modules. Each filter module may house a different type (e.g., material or configuration) of filter so that different filters may be compared and screened, such as for a selected use.

    MICRO ALTERNATING TANGENTIAL FLOW PERFUSION FILTER, MICRO BIOREACTOR, AND METHODS OF USE THEREOF
    24.
    发明申请
    MICRO ALTERNATING TANGENTIAL FLOW PERFUSION FILTER, MICRO BIOREACTOR, AND METHODS OF USE THEREOF 有权

    公开(公告)号：US20220251493A1

    公开(公告)日：2022-08-11

    申请号：US17729022

    申请日：2022-04-26

    Applicant: Repligen Corporation

    Inventor： Michael Bransby ,  Philip Yuen

    IPC: C12M1/00 ,  C12M1/26 ,  B01D61/18 ,  B01D61/14

    Abstract: A micro alternating tangential flow (microATF) perfusion filter includes a hollow cylinder having a proximal end and a distal end. The proximal end is connected in series to a permeate chamber, followed by a retentate chamber. The proximal end either (i) terminates in or at the permeate chamber, or (ii) terminates in or at the retentate chamber. The portion of the proximal end within the permeate chamber, in a case of (ii), possesses at least one opening allowing fluid communication between an inside of the hollow cylinder and the permeate chamber. The microATF perfusion filter further includes an inlet, positioned over the retentate chamber, for communication with a source of positive or negative pressure, and an outlet, positioned in a wall of the permeate chamber, which can be connected to a check valve, which, in turn, can be connected to a hydrophobic fluid vent filter.

    Methods, devices and systems for 3-stage filtration
    25.
    发明授权
    Methods, devices and systems for 3-stage filtration 有权

    公开(公告)号：US11028124B2

    公开(公告)日：2021-06-08

    申请号：US15972442

    申请日：2018-05-07

    Applicant: REPLIGEN CORPORATION

    Inventor： Michael Bransby

    IPC: C07K1/36 ,  B01D63/02 ,  B01D69/08

    Abstract: The present disclosure pertains to filtration methods comprising: passing a first fluid that comprises cells, cell debris and targeted product produced by the cells through a first filter thereby separating the first fluid into a first retentate comprising cells and a first permeate comprising targeted product and cell debris; combining resin beads having affinity for targeted product with the first permeate to form a second fluid containing resin beads with bound target product and cell debris; passing the second fluid through a second filter thereby separating the second fluid into a second retentate comprising resin beads with bound target product and a second permeate comprising cell debris; combining an elution buffer with the second retentate to form a third fluid that comprises a mixture of resin beads and unbound targeted product; and passing the third fluid through a third filter thereby separating resin beads from targeted product.

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