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公开(公告)号:US08144052B2
公开(公告)日:2012-03-27
申请号:US12580210
申请日:2009-10-15
申请人: Ken B. Cooper , Robert J. Dengler , Peter H. Siegel , Goutam Chattopadhyay , John S. Ward , Nuria Llombart Juan , Tomas E. Bryllert , Imran Mehdi , Jan A. Tarsala
发明人: Ken B. Cooper , Robert J. Dengler , Peter H. Siegel , Goutam Chattopadhyay , John S. Ward , Nuria Llombart Juan , Tomas E. Bryllert , Imran Mehdi , Jan A. Tarsala
CPC分类号: G01S13/89 , G01S7/024 , G01S7/03 , G01S7/35 , G01S13/34 , G01S13/87 , H01Q19/191 , H01Q19/195
摘要: A three-dimensional imaging radar operating at high frequency e.g., 670 GHz radar using low phase-noise synthesizers and a fast chirper to generate a frequency-modulated continuous-wave (FMCW) waveform, is disclosed that operates with a multiplexed beam to obtain range information simultaneously on multiple pixels of a target. A source transmit beam may be divided by a hybrid coupler into multiple transmit beams multiplexed together and directed to be reflected off a target and return as a single receive beam which is demultiplexed and processed to reveal range information of separate pixels of the target associated with each transmit beam simultaneously. The multiple transmit beams may be developed with appropriate optics to be temporally and spatially differentiated before being directed to the target. Temporal differentiation corresponds to a different intermediate frequencies separating the range information of the multiple pixels. Collinear transmit beams having differentiated polarizations may also be implemented.
摘要翻译: 公开了以高频率操作的三维成像雷达,例如使用低相位噪声合成器的670GHz雷达和用于产生调频连续波(FMCW)波形的快速啁啾声),其以多路波束操作以获得范围 信息同时在目标的多个像素上。 源发射波束可以被混合耦合器划分成多个复用在一起的多个发射波束并被引导为从目标反射并作为单个接收波束返回,该单个接收波束被解复用并被处理以显示与每一个相关联的目标的分离像素的范围信息 同时发射波束。 多个发射光束可以用合适的光学器件显影,以在被引导到目标之前在时间和空间上被区分。 时间微分对应于分离多个像素的范围信息的不同中间频率。 也可以实现具有差分极化的共线发射波束。
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公开(公告)号:US06761280B2
公开(公告)日:2004-07-13
申请号:US10033257
申请日:2001-12-27
申请人: Harry R. Zonker , Gary L. Myers , Robert E. Dick , Darl G. Boysel , John S. Ward
发明人: Harry R. Zonker , Gary L. Myers , Robert E. Dick , Darl G. Boysel , John S. Ward
IPC分类号: B65D1734
CPC分类号: B65D17/08 , B65D17/4012 , Y10S220/906
摘要: A sheet metal end shell for conversion into easy opening beer and beverage ends with reduced metal usage while maintaining commercially acceptable buckle resistance. The end shell has an upper chuckwall portion that is disposed at an angle of about 20-35 degrees to vertical, a countersink bead having a width of about 0.020-0.040 inch, and further preferably having a countersink depth of less than about 0.250 inch and a panel depth less than about 0.070 inch.
摘要翻译: 一种钣金端壳,用于转换成易于打开的啤酒和饮料端,同时保持商业上可接受的耐扣性。 端壳具有上部夹紧壁部分,其以垂直方向以大约20-35度的角度设置,具有约0.020-0.040英寸的宽度的凹坑,并且还优选地具有小于约0.250英寸的埋头孔深度, 面板深度小于约0.070英寸。
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公开(公告)号:US06429317B1
公开(公告)日:2002-08-06
申请号:US09117089
申请日:2000-09-05
申请人: Sean P. Hollinshead , Michael A. Staszak , John S. Ward , Joseph W. Wilson , Bret E. Huff , Philip F. Hughes , Jose S. Mendoza , Charles H. Mitch
发明人: Sean P. Hollinshead , Michael A. Staszak , John S. Ward , Joseph W. Wilson , Bret E. Huff , Philip F. Hughes , Jose S. Mendoza , Charles H. Mitch
IPC分类号: C07D20708
CPC分类号: C07D213/82 , C07C257/12 , C07C311/20 , C07C2602/08 , C07C2602/10 , C07D295/13 , C07D333/38 , C07D333/70 , C40B40/00
摘要: The present invention provides novel indane-like compounds which can be useful for treating psychosis and other conditions associated with the modulation of a muscarinic receptor. The invention provides formulations and methods for using the novel compounds.
摘要翻译: 本发明提供了可用于治疗与调节毒蕈碱受体相关的精神病和其它病症的新型吲哚类化合物。 本发明提供了使用新化合物的制剂和方法。
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公开(公告)号:US06187776B1
公开(公告)日:2001-02-13
申请号:US09359601
申请日:1999-07-23
申请人: Leander Merritt , John S. Ward
发明人: Leander Merritt , John S. Ward
IPC分类号: A61K31496
CPC分类号: C07D451/06 , C07D209/52 , C07D241/18 , C07D271/08 , C07D403/12 , C07D413/12 , C07D453/02 , C07D471/08 , C07D487/08
摘要: The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system caused by malfunctioning of the muscarinic cholinergic system.
摘要翻译: 本发明涉及治疗活性的氮杂环或氮杂双环化合物,其制备方法和包含该化合物的药物组合物。 新型化合物可用于治疗由毒蕈碱胆碱能系统功能障碍引起的中枢神经系统疾病。
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公开(公告)号:US5767280A
公开(公告)日:1998-06-16
申请号:US457934
申请日:1995-06-01
申请人: Roger L. Robey , John S. Ward
发明人: Roger L. Robey , John S. Ward
IPC分类号: A61K31/41 , A61K31/433 , A61P25/28 , C07D285/10
CPC分类号: C07D285/10
摘要: The present invention relates to a process for making intermediates useful for preparing therapeutically active azacyclic or azabicyclic compounds.
摘要翻译: 本发明涉及制备用于制备治疗活性的氮杂环或氮杂双环化合物的中间体的方法。
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公开(公告)号:US5665745A
公开(公告)日:1997-09-09
申请号:US470791
申请日:1995-06-06
申请人: Charles A. Alt , Leander Merritt , Gary A. Rhodes , Roger L. Robey , Eldon E. Van Meter , John S. Ward , Charles H. Mitch
发明人: Charles A. Alt , Leander Merritt , Gary A. Rhodes , Roger L. Robey , Eldon E. Van Meter , John S. Ward , Charles H. Mitch
IPC分类号: C07D285/06 , A61K31/41 , A61K31/425 , A61K31/433 , A61K31/435 , A61K31/445 , A61K31/46 , A61P1/00 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P27/02 , A61P43/00 , C07D285/10 , C07D417/12 , C07D451/02 , C07D451/04 , C07D451/06 , C07D453/02 , C07D453/06 , C07D471/04 , C07D471/08 , C07D487/08 , C07D417/14
CPC分类号: C07D285/10 , C07D417/12 , C07D451/06 , C07D453/02 , C07D453/06 , C07D471/04 , C07D471/08 , C07D487/08
摘要: The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system caused by malfunctioning of the muscarinic cholinergic system.
摘要翻译: 本发明涉及治疗活性的氮杂环或氮杂双环化合物,其制备方法和包含该化合物的药物组合物。 新型化合物可用于治疗由毒蕈碱胆碱能系统功能障碍引起的中枢神经系统疾病。
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公开(公告)号:US5646289A
公开(公告)日:1997-07-08
申请号:US468481
申请日:1995-06-06
申请人: Charles A. Alt , Leander Merritt , Gary A. Rhodes , Roger L. Robey , Eldon E. Van Meter , John S. Ward , Charles H. Mitch
发明人: Charles A. Alt , Leander Merritt , Gary A. Rhodes , Roger L. Robey , Eldon E. Van Meter , John S. Ward , Charles H. Mitch
IPC分类号: C07D285/06 , A61K31/41 , A61K31/425 , A61K31/433 , A61K31/435 , A61K31/445 , A61K31/46 , A61P1/00 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P27/02 , A61P43/00 , C07D285/10 , C07D417/12 , C07D451/02 , C07D451/04 , C07D451/06 , C07D453/02 , C07D453/06 , C07D471/04 , C07D471/08 , C07D487/08
CPC分类号: C07D285/10 , C07D417/12 , C07D451/06 , C07D453/02 , C07D453/06 , C07D471/04 , C07D471/08 , C07D487/08
摘要: The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system caused by malfunctioning of the muscarinic cholinergic system.
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公开(公告)号:US4271166A
公开(公告)日:1981-06-02
申请号:US963659
申请日:1978-11-24
申请人: John S. Ward
发明人: John S. Ward
IPC分类号: A01N43/82 , C07D285/12 , C07D285/135 , A01N43/40 , C07D275/02 , C07D417/04
CPC分类号: C07D285/135 , A01N43/82
摘要: A series of N-(1,3,4-thiadiazol-2-yl)benzamides, having a phenyl, naphthyl or hetero-aryl group at the 5-position of the thiadiazole ring and 2,6-substitution on the benzamide ring, are useful insecticides. The invention also provides insecticidal methods and compositions.
摘要翻译: 在噻二唑环5位具有苯基,萘基或杂芳基的一系列N-(1,3,4-噻二唑-2-基)苯甲酰胺和在苯甲酰胺环上的2,6-取代, 是有用的杀虫剂。 本发明还提供了杀虫方法和组合物。
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公开(公告)号:US6040442A
公开(公告)日:2000-03-21
申请号:US457082
申请日:1995-06-01
申请人: Leander Merritt , John S. Ward
发明人: Leander Merritt , John S. Ward
IPC分类号: A61K31/41 , A61K31/433 , A61K31/435 , A61P25/28 , C07D285/10 , C07D453/02 , C07D487/08 , C07D401/12 , C07D403/12 , C07D487/00
CPC分类号: C07D285/10 , C07D453/02 , C07D487/08
摘要: The presently claimed process provides a method for preparing compounds of the formula ##STR1## phosphorous (III) compound and a diester of azodicarboxylate.
摘要翻译: 目前要求保护的方法提供了制备式(III)化合物和偶氮二羧酸二酯的化合物的方法。
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公开(公告)号:US05998404A
公开(公告)日:1999-12-07
申请号:US443674
申请日:1995-06-01
申请人: Leander Merritt , John S. Ward
发明人: Leander Merritt , John S. Ward
IPC分类号: C07D401/12 , A61K31/41 , A61K31/435 , A61K31/495 , A61K31/55 , A61P25/28 , C07D209/52 , C07D241/18 , C07D271/08 , C07D403/12 , C07D413/12 , C07D451/02 , C07D451/06 , C07D453/02 , C07D471/08 , C07D487/08
CPC分类号: C07D451/06 , C07D209/52 , C07D241/18 , C07D271/08 , C07D403/12 , C07D413/12 , C07D453/02 , C07D471/08 , C07D487/08
摘要: The present invention relates to therapeutically active azacyclic or azabicyclic compounds of formula I ##STR1## and to pharmaceutical formulations comprising these compounds and methods of treatment comprising administering these compounds to a subject in need of treatment. The novel oxadiazole compounds, such as (.+-.)-3-butyloxy-4-(1-azabicyclo[2.2.2]octyl-3-oxy)-1,2,5-oxadiazole, are useful in treating central nervous system disorders caused by malfunctioning of the muscarinic cholinergic system.
摘要翻译: 本发明涉及式I的治疗活性的氮杂环或氮杂双环化合物和包含这些化合物的药物制剂和治疗方法,其包括向需要治疗的受试者施用这些化合物。 新的恶二唑化合物,例如(+/-) - 3-丁氧基-4-(1-氮杂双环[2.2.2]辛基-3-氧)-1,2,5-恶二唑可用于治疗中枢神经系统 由毒蕈碱胆碱能系统故障引起的疾病。
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